ZEB1

Zinc finger E-box binding homeobox 1
File:PBB Protein ZEB1 image.jpg PDB rendering based on 2e19.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2e19​
Identifiers
Symbols	ZEB1 ; AREB6; BZP; MGC133261; NIL-2-A; NIL-2A; TCF8; ZEB; ZFHEP; ZFHX1A
External IDs	Template:OMIM5 Template:MGI HomoloGene: 31779
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE ZEB1 210875 s at tn.png
File:PBB GE ZEB1 212758 s at tn.png
File:PBB GE ZEB1 212764 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Zinc finger E-box binding homeobox 1, also known as ZEB1, is a human gene.

TCF8 encodes a human zinc finger transcription factor that represses T-lymphocyte-specific IL2 gene (MIM 147680) expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription start site (Williams et al., 1991).[supplied by OMIM]

Further reading

• Williams TM, Montoya G, Wu Y; et al. (1992). "The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2". Genomics. 14 (1): 194–6. PMID 1427828.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Williams TM, Moolten D, Burlein J; et al. (1992). "Identification of a zinc finger protein that inhibits IL-2 gene expression". Science. 254 (5039): 1791–4. PMID 1840704.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Franklin AJ, Jetton TL, Shelton KD, Magnuson MA (1994). "BZP, a novel serum-responsive zinc finger protein that inhibits gene transcription". Mol. Cell. Biol. 14 (10): 6773–88. PMID 7935395.CS1 maint: Multiple names: authors list (link)
• Watanabe Y, Kawakami K, Hirayama Y, Nagano K (1994). "Transcription factors positively and negatively regulating the Na,K-ATPase alpha 1 subunit gene". J. Biochem. 114 (6): 849–55. PMID 8138542.CS1 maint: Multiple names: authors list (link)
• Ikeda K, Halle JP, Stelzer G; et al. (1998). "Involvement of negative cofactor NC2 in active repression by zinc finger-homeodomain transcription factor AREB6". Mol. Cell. Biol. 18 (1): 10–8. PMID 9418848.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Turner J, Crossley M (1998). "Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators". EMBO J. 17 (17): 5129–40. doi:10.1093/emboj/17.17.5129. PMID 9724649.
• Postigo AA, Dean DC (1999). "ZEB represses transcription through interaction with the corepressor CtBP". Proc. Natl. Acad. Sci. U.S.A. 96 (12): 6683–8. PMID 10359772.
• Hlubek F, Löhberg C, Meiler J; et al. (2001). "Tip60 is a cell-type-specific transcriptional regulator". J. Biochem. 129 (4): 635–41. PMID 11275565.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Locklin RM, Riggs BL, Hicok KC; et al. (2002). "Assessment of gene regulation by bone morphogenetic protein 2 in human marrow stromal cells using gene array technology". J. Bone Miner. Res. 16 (12): 2192–204. PMID 11760832.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shaheduzzaman S, Krishnan V, Petrovic A; et al. (2002). "Effects of HIV-1 Nef on cellular gene expression profiles". J. Biomed. Sci. 9 (1): 82–96. PMID 11810028.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Guaita S, Puig I, Franci C; et al. (2002). "Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression". J. Biol. Chem. 277 (42): 39209–16. doi:10.1074/jbc.M206400200. PMID 12161443.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Costantino ME, Stearman RP, Smith GE, Darling DS (2002). "Cell-specific phosphorylation of Zfhep transcription factor". Biochem. Biophys. Res. Commun. 296 (2): 368–73. PMID 12163027.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Postigo AA (2003). "Opposing functions of ZEB proteins in the regulation of the TGFbeta/BMP signaling pathway". EMBO J. 22 (10): 2443–52. doi:10.1093/emboj/cdg225. PMID 12743038.
• Postigo AA, Depp JL, Taylor JJ, Kroll KL (2003). "Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins". EMBO J. 22 (10): 2453–62. doi:10.1093/emboj/cdg226. PMID 12743039.CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dillner NB, Sanders MM (2004). "Transcriptional activation by the zinc-finger homeodomain protein delta EF1 in estrogen signaling cascades". DNA Cell Biol. 23 (1): 25–34. doi:10.1089/104454904322745907. PMID 14965470.
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shimizu S, Krafchak C, Fuse N; et al. (2005). "A locus for posterior polymorphous corneal dystrophy (PPCD3) maps to chromosome 10". Am. J. Med. Genet. A. 130 (4): 372–7. doi:10.1002/ajmg.a.30267. PMID 15384081.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Eger A, Aigner K, Sonderegger S; et al. (2005). "DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells". Oncogene. 24 (14): 2375–85. doi:10.1038/sj.onc.1208429. PMID 15674322.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)