MSMB
| Microseminoprotein, beta- | |||||||||||||
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File:PBB Protein MSMB image.jpg PDB rendering based on 2iz3. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | MSMB ; IGBF; MSP; MSPB; PN44; PRPS; PSP; PSP-94; PSP57; PSP94 | ||||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 1832 | ||||||||||||
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| RNA expression pattern | |||||||||||||
| File:PBB GE MSMB 210297 s at tn.png | |||||||||||||
| File:PBB GE MSMB 207430 s at tn.png | |||||||||||||
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| Orthologs | |||||||||||||
| Template:GNF Ortholog box | |||||||||||||
| Species | Human | Mouse | |||||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||||
| RefSeq (protein) | n/a | n/a | |||||||||||
| Location (UCSC) | n/a | n/a | |||||||||||
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Microseminoprotein, beta-, also known as MSMB, is a human gene.[1]
The protein encoded by this gene is a member of the immunoglobulin binding factor family. It is synthesized by the epithelial cells of the prostate gland and secreted into the seminal plasma. This protein has inhibin-like activity. It may have a role as an autocrine paracrine factor in uterine, breast and other female reproductive tissues. The expression of the encoded protein is found to be decreased in prostate cancer. Two alternatively spliced transcript variants encoding different isoforms are described for this gene. The use of alternate polyadenylation sites has been found for this gene.[1]
References
Further reading
- Ulvsbäck M, Spurr NK, Lundwall A (1992). "Assignment of the human gene for beta-microseminoprotein (MSMB) to chromosome 10 and demonstration of related genes in other vertebrates". Genomics. 11 (4): 920–4. PMID 1783399.
- Liang ZG, Kamada M, Koide SS (1991). "Structural identity of immunoglobulin binding factor and prostatic secretory protein of human seminal plasma". Biochem. Biophys. Res. Commun. 180 (1): 356–9. PMID 1930232.
- Nolet S, St-Louis D, Mbikay M, Chrétien M (1991). "Rapid evolution of prostatic protein PSP94 suggested by sequence divergence between rhesus monkey and human cDNAs". Genomics. 9 (4): 775–7. PMID 2037304.
- Nolet S, Mbikay M, Chrétien M (1991). "Prostatic secretory protein PSP94: gene organization and promoter sequence in rhesus monkey and human". Biochim. Biophys. Acta. 1089 (2): 247–9. PMID 2054385.
- Green CB, Liu WY, Kwok SC (1990). "Cloning and nucleotide sequence analysis of the human beta-microseminoprotein gene". Biochem. Biophys. Res. Commun. 167 (3): 1184–90. PMID 2322265.
- Ito Y, Tsuda R, Kimura H (1989). "Ultrastructural localizations of beta-microseminoprotein, a prostate-specific antigen, in human prostate and sperm: comparison with gamma-seminoprotein, another prostate-specific antigen". J. Lab. Clin. Med. 114 (3): 272–7. PMID 2475560.
- Ulvsbäck M, Lindström C, Weiber H; et al. (1989). "Molecular cloning of a small prostate protein, known as beta-microsemenoprotein, PSP94 or beta-inhibin, and demonstration of transcripts in non-genital tissues". Biochem. Biophys. Res. Commun. 164 (3): 1310–5. PMID 2590204.
- Abrahamsson PA, Andersson C, Björk T; et al. (1989). "Radioimmunoassay of beta-microseminoprotein, a prostatic-secreted protein present in sera of both men and women". Clin. Chem. 35 (7): 1497–503. PMID 2758596.
- Mbikay M, Nolet S, Fournier S; et al. (1987). "Molecular cloning and sequence of the cDNA for a 94-amino-acid seminal plasma protein secreted by the human prostate". DNA. 6 (1): 23–9. PMID 3829888.
- Akiyama K, Yoshioka Y, Schmid K; et al. (1985). "The amino acid sequence of human beta-microseminoprotein". Biochim. Biophys. Acta. 829 (2): 288–94. PMID 3995056.
- Seidah NG, Arbatti NJ, Rochemont J; et al. (1984). "Complete amino acid sequence of human seminal plasma beta-inhibin. Prediction of post Gln-Arg cleavage as a maturation site". FEBS Lett. 175 (2): 349–55. PMID 6434350.
- Liu AY, Bradner RC, Vessella RL (1994). "Decreased expression of prostatic secretory protein PSP94 in prostate cancer". Cancer Lett. 74 (1–2): 91–9. PMID 7506990.
- Xuan JW, Chin JL, Guo Y; et al. (1995). "Alternative splicing of PSP94 (prostatic secretory protein of 94 amino acids) mRNA in prostate tissue". Oncogene. 11 (6): 1041–7. PMID 7566962.
- Ochiai Y, Inazawa J, Ueyama H, Ohkubo I (1995). "Human gene for beta-microseminoprotein: its promoter structure and chromosomal localization". J. Biochem. 117 (2): 346–52. PMID 7608123.
- Ohkubo I, Tada T, Ochiai Y; et al. (1995). "Human seminal plasma beta-microseminoprotein: its purification, characterization, and immunohistochemical localization". Int. J. Biochem. Cell Biol. 27 (6): 603–11. doi:10.1016/1357-2725(95)00021-G. PMID 7671139.
- Fernlund P, Granberg LB, Roepstorff P (1994). "Amino acid sequence of beta-microseminoprotein from porcine seminal plasma". Arch. Biochem. Biophys. 309 (1): 70–6. PMID 8117114.
- Sasaki T, Matsumoto N, Jinno Y; et al. (1997). "Assignment of the human beta-microseminoprotein gene (MSMB) to chromosome 10q11.2". Cytogenet. Cell Genet. 72 (2–3): 177–8. PMID 8978767.
- Kamada M, Mori H, Maeda N; et al. (1998). "beta-Microseminoprotein/prostatic secretory protein is a member of immunoglobulin binding factor family". Biochim. Biophys. Acta. 1388 (1): 101–10. PMID 9774712.
- Mäkinen M, Valtonen-André C, Lundwall A (1999). "New world, but not Old World, monkeys carry several genes encoding beta-microseminoprotein". Eur. J. Biochem. 264 (2): 407–14. PMID 10491085.
- Baijal-Gupta M, Clarke MW, Finkelman MA; et al. (2000). "Prostatic secretory protein (PSP94) expression in human female reproductive tissues, breast and in endometrial cancer cell lines". J. Endocrinol. 165 (2): 425–33. PMID 10810306.
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