PFKFB3

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
File:PBB Protein PFKFB3 image.jpg PDB rendering based on 2axn.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2axn​
Identifiers
Symbols	PFKFB3 ; IPFK2; PFK2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 88708
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PFKFB3 202464 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3, also known as PFKFB3, is a human gene.

Further reading

• Sakai A, Kato M, Fukasawa M; et al. (1996). "Cloning of cDNA encoding for a novel isozyme of fructose 6-phosphate, 2-kinase/fructose 2,6-bisphosphatase from human placenta". J. Biochem. 119 (3): 506–11. PMID 8830046.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hamilton JA, Callaghan MJ, Sutherland RL, Watts CK (1997). "Identification of PRG1, a novel progestin-responsive gene with sequence homology to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase". Mol. Endocrinol. 11 (4): 490–502. PMID 9092801.CS1 maint: Multiple names: authors list (link)
• Nicholl J, Hamilton JA, Sutherland GR; et al. (1997). "The third human isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3) map position 10p14-p15". Chromosome Res. 5 (2): 150. PMID 9146922.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sakakibara R, Kato M, Okamura N; et al. (1997). "Characterization of a human placental fructose-6-phosphate, 2-kinase/fructose-2,6-bisphosphatase". J. Biochem. 122 (1): 122–8. PMID 9276680.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Manzano A, Rosa JL, Ventura F; et al. (1999). "Molecular cloning, expression, and chromosomal localization of a ubiquitously expressed human 6-phosphofructo-2-kinase/ fructose-2, 6-bisphosphatase gene (PFKFB3)". Cytogenet. Cell Genet. 83 (3–4): 214–7. PMID 10072580.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chesney J, Mitchell R, Benigni F; et al. (1999). "An inducible gene product for 6-phosphofructo-2-kinase with an AU-rich instability element: role in tumor cell glycolysis and the Warburg effect". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 3047–52. PMID 10077634.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scanlan MJ, Gordan JD, Williamson B; et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456–64. PMID 10508479.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fukasawa M, Takayama E, Shinomiya N; et al. (2000). "Identification of the promoter region of human placental 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene". Biochem. Biophys. Res. Commun. 267 (3): 703–8. doi:10.1006/bbrc.1999.2022. PMID 10673355.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kessler R, Eschrich K (2001). "Splice isoforms of ubiquitous 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in human brain". Brain Res. Mol. Brain Res. 87 (2): 190–5. PMID 11245921.
• Navarro-Sabaté A, Manzano A, Riera L; et al. (2001). "The human ubiquitous 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene (PFKFB3): promoter characterization and genomic structure". Gene. 264 (1): 131–8. PMID 11245987.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Atsumi T, Chesney J, Metz C; et al. (2002). "High expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (iPFK-2; PFKFB3) in human cancers". Cancer Res. 62 (20): 5881–7. PMID 12384552.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Riera L, Obach M, Navarro-Sabaté A; et al. (2003). "Regulation of ubiquitous 6-phosphofructo-2-kinase by the ubiquitin-proteasome proteolytic pathway during myogenic C2C12 cell differentiation". FEBS Lett. 550 (1–3): 23–9. PMID 12935880.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mahlknecht U, Chesney J, Hoelzer D, Bucala R (2004). "Cloning and chromosomal characterization of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 gene (PFKFB3, iPFK2)". Int. J. Oncol. 23 (4): 883–91. PMID 12963966.CS1 maint: Multiple names: authors list (link)
• Obach M, Navarro-Sabaté A, Caro J; et al. (2005). "6-Phosphofructo-2-kinase (pfkfb3) gene promoter contains hypoxia-inducible factor-1 binding sites necessary for transactivation in response to hypoxia". J. Biol. Chem. 279 (51): 53562–70. doi:10.1074/jbc.M406096200. PMID 15466858.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Manes NP, El-Maghrabi MR (2005). "The kinase activity of human brain 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is regulated via inhibition by phosphoenolpyruvate". Arch. Biochem. Biophys. 438 (2): 125–36. doi:10.1016/j.abb.2005.04.011. PMID 15896703.
• Bando H, Atsumi T, Nishio T; et al. (2005). "Phosphorylation of the 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase/PFKFB3 family of glycolytic regulators in human cancer". Clin. Cancer Res. 11 (16): 5784–92. doi:10.1158/1078-0432.CCR-05-0149. PMID 16115917.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Atsumi T, Nishio T, Niwa H; et al. (2006). "Expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase/PFKFB3 isoforms in adipocytes and their potential role in glycolytic regulation". Diabetes. 54 (12): 3349–57. PMID 16306349.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Minchenko OH, Ogura T, Opentanova IL; et al. (2006). "Splice isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4: expression and hypoxic regulation". Mol. Cell. Biochem. 280 (1–2): 227–34. doi:10.1007/s11010-005-8009-6. PMID 16311927.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)