CYP26A1

Cytochrome P450, family 26, subfamily A, polypeptide 1
Identifiers
Symbols	CYP26A1 ; CP26; CYP26; P450RAI; P450RAI1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37349
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Cytochrome P450, family 26, subfamily A, polypeptide 1, also known as CYP26A1, is a human gene.

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported.

Further reading

• Duell EA, Kang S, Voorhees JJ (1996). "Retinoic acid isomers applied to human skin in vivo each induce a 4-hydroxylase that inactivates only trans retinoic acid". J. Invest. Dermatol. 106 (2): 316–20. PMID 8601734.CS1 maint: Multiple names: authors list (link)
• White JA, Beckett-Jones B, Guo YD; et al. (1997). "cDNA cloning of human retinoic acid-metabolizing enzyme (hP450RAI) identifies a novel family of cytochromes P450". J. Biol. Chem. 272 (30): 18538–41. PMID 9228017.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ray WJ, Bain G, Yao M, Gottlieb DI (1997). "CYP26, a novel mammalian cytochrome P450, is induced by retinoic acid and defines a new family". J. Biol. Chem. 272 (30): 18702–8. PMID 9228041.CS1 maint: Multiple names: authors list (link)
• White JA, Beckett B, Scherer SW; et al. (1998). "P450RAI (CYP26A1) maps to human chromosome 10q23-q24 and mouse chromosome 19C2-3". Genomics. 48 (2): 270–2. doi:10.1006/geno.1997.5157. PMID 9521883.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sonneveld E, van den Brink CE, van der Leede BM; et al. (1998). "Human retinoic acid (RA) 4-hydroxylase (CYP26) is highly specific for all-trans-RA and can be induced through RA receptors in human breast and colon carcinoma cells". Cell Growth Differ. 9 (8): 629–37. PMID 9716180.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Trofimova-Griffin ME, Juchau MR (1998). "Expression of cytochrome P450RAI (CYP26) in human fetal hepatic and cephalic tissues". Biochem. Biophys. Res. Commun. 252 (2): 487–91. doi:10.1006/bbrc.1998.9659. PMID 9826557.
• Popa C, Dicker AJ, Dahler AL, Saunders NA (2000). "Cytochrome P450, CYP26AI, is expressed at low levels in human epidermal keratinocytes and is not retinoic acid-inducible". Br. J. Dermatol. 141 (3): 460–8. PMID 10583049.CS1 maint: Multiple names: authors list (link)
• McSorley LC, Daly AK (2000). "Identification of human cytochrome P450 isoforms that contribute to all-trans-retinoic acid 4-hydroxylation". Biochem. Pharmacol. 60 (4): 517–26. PMID 10874126.
• Loudig O, Babichuk C, White J; et al. (2001). "Cytochrome P450RAI(CYP26) promoter: a distinct composite retinoic acid response element underlies the complex regulation of retinoic acid metabolism". Mol. Endocrinol. 14 (9): 1483–97. PMID 10976925.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Deng L, Shipley GL, Loose-Mitchell DS; et al. (2003). "Coordinate regulation of the production and signaling of retinoic acid by estrogen in the human endometrium". J. Clin. Endocrinol. Metab. 88 (5): 2157–63. PMID 12727970.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Won JY, Nam EC, Yoo SJ; et al. (2004). "The effect of cellular retinoic acid binding protein-I expression on the CYP26-mediated catabolism of all-trans retinoic acid and cell proliferation in head and neck squamous cell carcinoma". Metab. Clin. Exp. 53 (8): 1007–12. PMID 15281009.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Loudig O, Maclean GA, Dore NL; et al. (2006). "Transcriptional co-operativity between distant retinoic acid response elements in regulation of Cyp26A1 inducibility". Biochem. J. 392 (Pt 1): 241–8. doi:10.1042/BJ20050874. PMID 16053444.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ozpolat B, Mehta K, Lopez-Berestein G (2005). "Regulation of a highly specific retinoic acid-4-hydroxylase (CYP26A1) enzyme and all-trans-retinoic acid metabolism in human intestinal, liver, endothelial, and acute promyelocytic leukemia cells". Leuk. Lymphoma. 46 (10): 1497–506. doi:10.1080/10428190500174737. PMID 16194896.CS1 maint: Multiple names: authors list (link)
• Heise R, Mey J, Neis MM; et al. (2007). "Skin retinoid concentrations are modulated by CYP26AI expression restricted to basal keratinocytes in normal human skin and differentiated 3D skin models". J. Invest. Dermatol. 126 (11): 2473–80. doi:10.1038/sj.jid.5700432. PMID 16778795.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rat E, Billaut-Laden I, Allorge D; et al. (2006). "Evidence for a functional genetic polymorphism of the human retinoic acid-metabolizing enzyme CYP26A1, an enzyme that may be involved in spina bifida". Birth Defects Res. Part A Clin. Mol. Teratol. 76 (6): 491–8. doi:10.1002/bdra.20275. PMID 16933217.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gomaa MS, Yee SW, Milbourne CE; et al. (2007). "Homology model of human retinoic acid metabolising enzyme cytochrome P450 26A1 (CYP26A1): active site architecture and ligand binding". J Enzyme Inhib Med Chem. 21 (4): 361–9. PMID 17059167.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Quere R, Baudet A, Cassinat B; et al. (2007). "Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity". Blood. 109 (10): 4450–60. doi:10.1182/blood-2006-10-051086. PMID 17218384.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lee SJ, Perera L, Coulter SJ; et al. (2007). "The discovery of new coding alleles of human CYP26A1 that are potentially defective in the metabolism of all-trans retinoic acid and their assessment in a recombinant cDNA expression system". Pharmacogenet. Genomics. 17 (3): 169–80. doi:10.1097/FPC.0b013e32801152d6. PMID 17460545.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)