TRDMT1

TRNA aspartic acid methyltransferase 1
Identifiers
Symbols	TRDMT1 ; DNMT2; M.HsaIIP; PuMet; RNMT1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3249
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE TRDMT1 206308 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

TRNA aspartic acid methyltransferase 1, also known as TRDMT1, is a human gene.

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a protein with similarity to DNA methyltransferases, but this protein does not display methyltransferase activity. The protein strongly binds DNA, suggesting that it may mark specific sequences in the genome. Alternative splicing results in multiple transcript variants encoding different isoforms.

Further reading

• Yoder JA, Bestor TH (1998). "A candidate mammalian DNA methyltransferase related to pmt1p of fission yeast". Hum. Mol. Genet. 7 (2): 279–84. PMID 9425235.
• Okano M, Xie S, Li E (1998). "Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells". Nucleic Acids Res. 26 (11): 2536–40. PMID 9592134.CS1 maint: Multiple names: authors list (link)
• Van den Wyngaert I, Sprengel J, Kass SU, Luyten WH (1998). "Cloning and analysis of a novel human putative DNA methyltransferase". FEBS Lett. 426 (2): 283–9. PMID 9599025.CS1 maint: Multiple names: authors list (link)
• Vilain A, Apiou F, Dutrillaux B, Malfoy B (1998). "Assignment of candidate DNA methyltransferase gene (DNMT2) to human chromosome band 10p15.1 by in situ hybridization". Cytogenet. Cell Genet. 82 (1–2): 120. PMID 9763678.CS1 maint: Multiple names: authors list (link)
• Dong A, Yoder JA, Zhang X; et al. (2001). "Structure of human DNMT2, an enigmatic DNA methyltransferase homolog that displays denaturant-resistant binding to DNA". Nucleic Acids Res. 29 (2): 439–48. PMID 11139614.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Franchina M, Hooper J, Kay PH (2001). "Five novel alternatively spliced transcripts of DNA (cytosine-5) methyltransferase 2 in human peripheral blood leukocytes". Int. J. Biochem. Cell Biol. 33 (11): 1104–15. PMID 11551826.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hermann A, Schmitt S, Jeltsch A (2003). "The human Dnmt2 has residual DNA-(cytosine-C5) methyltransferase activity". J. Biol. Chem. 278 (34): 31717–21. doi:10.1074/jbc.M305448200. PMID 12794065.CS1 maint: Multiple names: authors list (link)
• Deloukas P, Earthrowl ME, Grafham DV; et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xiong Y, Dowdy SC, Xue A; et al. (2005). "Opposite alterations of DNA methyltransferase gene expression in endometrioid and serous endometrial cancers". Gynecol. Oncol. 96 (3): 601–9. doi:10.1016/j.ygyno.2004.11.047. PMID 15721400.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stelzl U, Worm U, Lalowski M; et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pang ST, Weng WH, Flores-Morales A; et al. (2006). "Cytogenetic and expression profiles associated with transformation to androgen-resistant prostate cancer". Prostate. 66 (2): 157–72. doi:10.1002/pros.20328. PMID 16173030.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Goll MG, Kirpekar F, Maggert KA; et al. (2006). "Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2". Science. 311 (5759): 395–8. doi:10.1126/science.1120976. PMID 16424344.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)