DDIT4

DNA-damage-inducible transcript 4
Identifiers
Symbols	DDIT4 ; Dig2; FLJ20500; REDD-1; REDD1; RP11-442H21.1; RTP801
External IDs	Template:OMIM5 Template:MGI HomoloGene: 10400
Gene ontology
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

DNA-damage-inducible transcript 4, also known as DDIT4, is a human gene.

Further reading

• Ellisen LW (2007). "Growth control under stress: mTOR regulation through the REDD1-TSC pathway". Cell Cycle. 4 (11): 1500–02. PMID 16258273.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.CS1 maint: Multiple names: authors list (link)
• Wiemann S, Weil B, Wellenreuther R; et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Simpson JC, Wellenreuther R, Poustka A; et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shoshani T, Faerman A, Mett I; et al. (2002). "Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis". Mol. Cell. Biol. 22 (7): 2283–93. PMID 11884613.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ellisen LW, Ramsayer KD, Johannessen CM; et al. (2003). "REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species". Mol. Cell. 10 (5): 995–1005. PMID 12453409.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kim JR, Lee SR, Chung HJ; et al. (2004). "Identification of amyloid beta-peptide responsive genes by cDNA microarray technology: involvement of RTP801 in amyloid beta-peptide toxicity". Exp. Mol. Med. 35 (5): 403–11. PMID 14646594.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brandenberger R, Wei H, Zhang S; et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lee M, Bikram M, Oh S; et al. (2004). "Sp1-dependent regulation of the RTP801 promoter and its application to hypoxia-inducible VEGF plasmid for ischemic disease". Pharm. Res. 21 (5): 736–41. PMID 15180327.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wiemann S, Arlt D, Huber W; et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schwarzer R, Tondera D, Arnold W; et al. (2005). "REDD1 integrates hypoxia-mediated survival signaling downstream of phosphatidylinositol 3-kinase". Oncogene. 24 (7): 1138–49. doi:10.1038/sj.onc.1208236. PMID 15592522.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Corradetti MN, Inoki K, Guan KL (2005). "The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway". J. Biol. Chem. 280 (11): 9769–72. doi:10.1074/jbc.C400557200. PMID 15632201.CS1 maint: Multiple names: authors list (link)
• Sofer A, Lei K, Johannessen CM, Ellisen LW (2005). "Regulation of mTOR and cell growth in response to energy stress by REDD1". Mol. Cell. Biol. 25 (14): 5834–45. doi:10.1128/MCB.25.14.5834-5845.2005. PMID 15988001.CS1 maint: Multiple names: authors list (link)
• Oh JH, Yang JO, Hahn Y; et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mehrle A, Rosenfelder H, Schupp I; et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lim J, Hao T, Shaw C; et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Malagelada C, Ryu EJ, Biswas SC; et al. (2006). "RTP801 is elevated in Parkinson brain substantia nigral neurons and mediates death in cellular models of Parkinson's disease by a mechanism involving mammalian target of rapamycin inactivation". J. Neurosci. 26 (39): 9996–10005. doi:10.1523/JNEUROSCI.3292-06.2006. PMID 17005863.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jin HO, An S, Lee HC; et al. (2007). "Hypoxic condition- and high cell density-induced expression of Redd1 is regulated by activation of hypoxia-inducible factor-1alpha and Sp1 through the phosphatidylinositol 3-kinase/Akt signaling pathway". Cell. Signal. 19 (7): 1393–403. doi:10.1016/j.cellsig.2006.12.014. PMID 17307335.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)