RGS10

Regulator of G-protein signalling 10
File:PBB Protein RGS10 image.jpg PDB rendering based on 2dlr.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2dlr​, 2i59​, 2ihb​
Identifiers
Symbols	RGS10 ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37710
Gene ontology Molecular function Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE RGS10 204319 s at tn.png
File:PBB GE RGS10 204316 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Regulator of G-protein signalling 10, also known as RGS10, is a human gene.

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene.

Further reading

• Hunt TW, Fields TA, Casey PJ, Peralta EG (1996). "RGS10 is a selective activator of G alpha i GTPase activity". Nature. 383 (6596): 175–7. doi:10.1038/383175a0. PMID 8774883.CS1 maint: Multiple names: authors list (link)
• Popov S, Yu K, Kozasa T, Wilkie TM (1997). "The regulators of G protein signaling (RGS) domains of RGS4, RGS10, and GAIP retain GTPase activating protein activity in vitro". Proc. Natl. Acad. Sci. U.S.A. 94 (14): 7216–20. PMID 9207071.CS1 maint: Multiple names: authors list (link)
• Tu Y, Wang J, Ross EM (1997). "Inhibition of brain Gz GAP and other RGS proteins by palmitoylation of G protein alpha subunits". Science. 278 (5340): 1132–5. PMID 9353196.CS1 maint: Multiple names: authors list (link)
• Tu Y, Popov S, Slaughter C, Ross EM (2000). "Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10". J. Biol. Chem. 274 (53): 38260–7. PMID 10608901.CS1 maint: Multiple names: authors list (link)
• Popov SG, Krishna UM, Falck JR, Wilkie TM (2000). "Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity". J. Biol. Chem. 275 (25): 18962–8. doi:10.1074/jbc.M001128200. PMID 10747990.CS1 maint: Multiple names: authors list (link)
• Chatterjee TK, Fisher RA (2000). "Cytoplasmic, nuclear, and golgi localization of RGS proteins. Evidence for N-terminal and RGS domain sequences as intracellular targeting motifs". J. Biol. Chem. 275 (31): 24013–21. doi:10.1074/jbc.M002082200. PMID 10791963.
• Burgon PG, Lee WL, Nixon AB; et al. (2001). "Phosphorylation and nuclear translocation of a regulator of G protein signaling (RGS10)". J. Biol. Chem. 276 (35): 32828–34. doi:10.1074/jbc.M100960200. PMID 11443111.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gagnon AW, Murray DL, Leadley RJ (2002). "Cloning and characterization of a novel regulator of G protein signalling in human platelets". Cell. Signal. 14 (7): 595–606. PMID 11955952.CS1 maint: Multiple names: authors list (link)
• Castro-Fernández C, Conn PM (2003). "Regulation of the gonadotropin-releasing hormone receptor (GnRHR) by RGS proteins: role of the GnRHR carboxyl-terminus". Mol. Cell. Endocrinol. 191 (2): 149–56. PMID 12062898.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Oh JH, Yang JO, Hahn Y; et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lee HK, Rhee KH, Kim CW; et al. (2006). "Crystallization and preliminary X-ray crystallographic analysis of human RGS10 complexed with Galphai3". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 61 (Pt 9): 831–3. doi:10.1107/S1744309105023602. PMID 16511171.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)