VPS26A

Vacuolar protein sorting 26 homolog A (S. pombe)
File:PBB Protein VPS26A image.jpg PDB rendering based on 2fau.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2fau​
Identifiers
Symbols	VPS26A ; FLJ12930; HB58; Hbeta58; PEP8A; VPS26
External IDs	Template:OMIM5 Template:MGI HomoloGene: 68420
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE VPS26A 201807 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Vacuolar protein sorting 26 homolog A (S. pombe), also known as VPS26A, is a human gene.

This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms.

Further reading

• Lee JJ, Radice G, Perkins CP, Costantini F (1992). "Identification and characterization of a novel, evolutionarily conserved gene disrupted by the murine H beta 58 embryonic lethal transgene insertion". Development. 115 (1): 277–88. PMID 1638986.CS1 maint: Multiple names: authors list (link)
• Mao M, Fu G, Wu JS; et al. (1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8175–80. PMID 9653160.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang QH, Ye M, Wu XY; et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. PMID 11042152.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Haft CR, de la Luz Sierra M, Bafford R; et al. (2001). "Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes". Mol. Biol. Cell. 11 (12): 4105–16. PMID 11102511.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Reddy JV, Seaman MN (2002). "Vps26p, a component of retromer, directs the interactions of Vps35p in endosome-to-Golgi retrieval". Mol. Biol. Cell. 12 (10): 3242–56. PMID 11598206.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Deloukas P, Earthrowl ME, Grafham DV; et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vergés M, Luton F, Gruber C; et al. (2004). "The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor". Nat. Cell Biol. 6 (8): 763–9. doi:10.1038/ncb1153. PMID 15247922.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mingot JM, Bohnsack MT, Jäkle U, Görlich D (2005). "Exportin 7 defines a novel general nuclear export pathway". EMBO J. 23 (16): 3227–36. doi:10.1038/sj.emboj.7600338. PMID 15282546.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kerr MC, Bennetts JS, Simpson F; et al. (2006). "A novel mammalian retromer component, Vps26B". Traffic. 6 (11): 991–1001. doi:10.1111/j.1600-0854.2005.00328.x. PMID 16190980.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Small SA, Kent K, Pierce A; et al. (2006). "Model-guided microarray implicates the retromer complex in Alzheimer's disease". Ann. Neurol. 58 (6): 909–19. doi:10.1002/ana.20667. PMID 16315276.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gullapalli A, Wolfe BL, Griffin CT; et al. (2006). "An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexins". Mol. Biol. Cell. 17 (3): 1228–38. doi:10.1091/mbc.E05-09-0899. PMID 16407403.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shi H, Rojas R, Bonifacino JS, Hurley JH (2006). "The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain". Nat. Struct. Mol. Biol. 13 (6): 540–8. doi:10.1038/nsmb1103. PMID 16732284.CS1 maint: Multiple names: authors list (link)
• Riemenschneider M, Schoepfer-Wendels A, Friedrich P; et al. (2007). "No association of vacuolar protein sorting 26 polymorphisms with Alzheimer's disease". Neurobiol. Aging. 28 (6): 883–4. doi:10.1016/j.neurobiolaging.2006.05.009. PMID 16784798.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rojas R, Kametaka S, Haft CR, Bonifacino JS (2007). "Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors". Mol. Cell. Biol. 27 (3): 1112–24. doi:10.1128/MCB.00156-06. PMID 17101778.CS1 maint: Multiple names: authors list (link)