PI4K2A
| Phosphatidylinositol 4-kinase type II | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | PI4KII ; DKFZP761G1923; RP11-548K23.6 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 6239 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE PI4KII 209345 s at tn.png | |||||||||||
| File:PBB GE PI4KII 209346 s at tn.png | |||||||||||
| File:PBB GE PI4KII 215134 at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Phosphatidylinositol 4-kinase type II, also known as PI4KII, is a human gene.[1]
Phosphatidylinositolpolyphosphates (PtdInsPs) are centrally involved in many biologic processes, ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4KII phosphorylates PtdIns at the D-4 position, an essential step in the biosynthesis of PtdInsPs (Barylko et al., 2001).[supplied by OMIM][1]
References
Further reading
- Andersson B, Wentland MA, Ricafrente JY; et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
- Berditchevski F, Tolias KF, Wong K; et al. (1997). "A novel link between integrins, transmembrane-4 superfamily proteins (CD63 and CD81), and phosphatidylinositol 4-kinase". J. Biol. Chem. 272 (5): 2595–8. PMID 9006891.
- Yu W, Andersson B, Worley KC; et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. PMID 9110174.
- Claas C, Stipp CS, Hemler ME (2001). "Evaluation of prototype transmembrane 4 superfamily protein complexes and their relation to lipid rafts". J. Biol. Chem. 276 (11): 7974–84. doi:10.1074/jbc.M008650200. PMID 11113129.
- Barylko B, Gerber SH, Binns DD; et al. (2001). "A novel family of phosphatidylinositol 4-kinases conserved from yeast to humans". J. Biol. Chem. 276 (11): 7705–8. doi:10.1074/jbc.C000861200. PMID 11244087.
- Minogue S, Anderson JS, Waugh MG; et al. (2001). "Cloning of a human type II phosphatidylinositol 4-kinase reveals a novel lipid kinase family". J. Biol. Chem. 276 (20): 16635–40. doi:10.1074/jbc.M100982200. PMID 11279162.
- Wei YJ, Sun HQ, Yamamoto M; et al. (2003). "Type II phosphatidylinositol 4-kinase beta is a cytosolic and peripheral membrane protein that is recruited to the plasma membrane and activated by Rac-GTP". J. Biol. Chem. 277 (48): 46586–93. doi:10.1074/jbc.M206860200. PMID 12324459.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Waugh MG, Minogue S, Anderson JS; et al. (2003). "Localization of a highly active pool of type II phosphatidylinositol 4-kinase in a p97/valosin-containing-protein-rich fraction of the endoplasmic reticulum". Biochem. J. 373 (Pt 1): 57–63. doi:10.1042/BJ20030089. PMID 12650639.
- Wang YJ, Wang J, Sun HQ; et al. (2003). "Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor AP-1 complexes to the Golgi". Cell. 114 (3): 299–310. PMID 12914695.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
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