FSHB

Follicle stimulating hormone, beta polypeptide
PDB rendering based on 1fl7.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1fl7​, 1xwd​
Identifiers
Symbols	FSHB ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 430
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Follicle stimulating hormone, beta polypeptide, also known as FSHB, is a human gene.

The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein.

Further reading

• Barrios-De-Tomasi J, Timossi C, Merchant H; et al. (2002). "Assessment of the in vitro and in vivo biological activities of the human follicle-stimulating isohormones". Mol. Cell. Endocrinol. 186 (2): 189–98. PMID 11900895.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Saxena BB, Rathnam P (1976). "Amino acid sequence of the beta subunit of follicle-stimulating hormone from human pituitary glands". J. Biol. Chem. 251 (4): 993–1005. PMID 1249074.
• Keene JL, Matzuk MM, Otani T; et al. (1989). "Expression of biologically active human follitropin in Chinese hamster ovary cells". J. Biol. Chem. 264 (9): 4769–75. PMID 2494176.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Watkins PC, Eddy R, Beck AK; et al. (1987). "DNA sequence and regional assignment of the human follicle-stimulating hormone beta-subunit gene to the short arm of human chromosome 11". DNA. 6 (3): 205–12. PMID 2885163.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jameson JL, Becker CB, Lindell CM, Habener JF (1988). "Human follicle-stimulating hormone beta-subunit gene encodes multiple messenger ribonucleic acids". Mol. Endocrinol. 2 (9): 806–15. PMID 3139991.CS1 maint: Multiple names: authors list (link)
• Shome B, Parlow AF, Liu WK; et al. (1989). "A reevaluation of the amino acid sequence of human follitropin beta-subunit". J. Protein Chem. 7 (4): 325–39. PMID 3151250.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shome B, Parlow AF (1974). "Human follicle stimulating hormone: first proposal for the amino acid sequence of the hormone-specific, beta subunit (hFSHb)". J. Clin. Endocrinol. Metab. 39 (1): 203–5. PMID 4835136.
• Fujiki Y, Rathnam P, Saxena BB (1980). "Studies on the disulfide bonds in human pituitary follicle-stimulating hormone". Biochim. Biophys. Acta. 624 (2): 428–35. PMID 6774759.CS1 maint: Multiple names: authors list (link)
• Böckers TM, Nieschlag E, Kreutz MR, Bergmann M (1995). "Localization of follicle-stimulating hormone (FSH) immunoreactivity and hormone receptor mRNA in testicular tissue of infertile men". Cell Tissue Res. 278 (3): 595–600. PMID 7850869.CS1 maint: Multiple names: authors list (link)
• Matthews CH, Borgato S, Beck-Peccoz P; et al. (1993). "Primary amenorrhoea and infertility due to a mutation in the beta-subunit of follicle-stimulating hormone". Nat. Genet. 5 (1): 83–6. doi:10.1038/ng0993-83. PMID 8220432.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Layman LC, Lee EJ, Peak DB; et al. (1997). "Delayed puberty and hypogonadism caused by mutations in the follicle-stimulating hormone beta-subunit gene". N. Engl. J. Med. 337 (9): 607–11. PMID 9271483.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cargill M, Altshuler D, Ireland J; et al. (1999). "Characterization of single-nucleotide polymorphisms in coding regions of human genes". Nat. Genet. 22 (3): 231–8. doi:10.1038/10290. PMID 10391209.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Grasso P, Rozhavskaya-Arena M, Reichert LE (1999). "Cysteine residues in a synthetic peptide corresponding to human follicle-stimulating hormone beta-subunit receptor-binding domain 81-95 [hFSH-beta-(81-95)] modulate the in vivo effects of hFSH-beta-(81-95) on the mouse estrous cycle". Regul. Pept. 81 (1–3): 67–71. PMID 10395410.CS1 maint: Multiple names: authors list (link)
• Ben-Menahem D, Hyde R, Pixley M; et al. (1999). "Synthesis of multi-subunit domain gonadotropin complexes: a model for alpha/beta heterodimer formation". Biochemistry. 38 (46): 15070–7. PMID 10563789.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dias Neto E, Correa RG, Verjovski-Almeida S; et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.CS1 maint: Multiple names: authors list (link)
• Fox KM, Dias JA, Van Roey P (2001). "Three-dimensional structure of human follicle-stimulating hormone". Mol. Endocrinol. 15 (3): 378–89. PMID 11222739.CS1 maint: Multiple names: authors list (link)
• Amoresano A, Orrù S, Siciliano RA; et al. (2002). "Assignment of the complete disulphide bridge pattern in the human recombinant follitropin beta-chain". Biol. Chem. 382 (6): 961–8. PMID 11501762.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Walton WJ, Nguyen VT, Butnev VY; et al. (2001). "Characterization of human FSH isoforms reveals a nonglycosylated beta-subunit in addition to the conventional glycosylated beta-subunit". J. Clin. Endocrinol. Metab. 86 (8): 3675–85. PMID 11502795.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)