PIK3C2A

Phosphatidylinositol 3[prime]-kinase, class 2, alpha polypeptide
File:PBB Protein PI3KC2A image.jpg PDB rendering based on 2ar5.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2ar5​, 2b3r​, 2iwl​
Identifiers
Symbols	PIK3C2A ; CPK; DKFZp686L193; MGC142218; PI3-K-C2(ALPHA); PI3-K-C2A
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20581
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PIK3C2A gnf1h00038 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Phosphatidylinositol 3[prime]-kinase, class 2, alpha polypeptide, also known as PI3KC2A, is a human gene.

The protein encoded by this gene belongs to the phosphatidylinositol 3[prime]-kinase (PI3K) family. PI3 kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3 kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3 kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmannin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling.

Further reading

• Lee C, Liu QH, Tomkowicz B; et al. (2004). "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways". J. Leukoc. Biol. 74 (5): 676–82. doi:10.1189/jlb.0503206. PMID 12960231.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Milani D, Mazzoni M, Borgatti P; et al. (1996). "Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells". J. Biol. Chem. 271 (38): 22961–4. PMID 8798481.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Domin J, Pages F, Volinia S; et al. (1997). "Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin". Biochem. J. 326 ( Pt 1): 139–47. PMID 9337861.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mazerolles F, Barbat C, Fischer A (1997). "Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity". Eur. J. Immunol. 27 (9): 2457–65. PMID 9341793.CS1 maint: Multiple names: authors list (link)
• Borgatti P, Zauli G, Colamussi ML; et al. (1998). "Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells". Eur. J. Immunol. 27 (11): 2805–11. PMID 9394803.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Borgatti P, Zauli G, Cantley LC, Capitani S (1998). "Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells". Biochem. Biophys. Res. Commun. 242 (2): 332–7. PMID 9446795.CS1 maint: Multiple names: authors list (link)
• Zhang J, Banfić H, Straforini F; et al. (1998). "A type II phosphoinositide 3-kinase is stimulated via activated integrin in platelets. A source of phosphatidylinositol 3-phosphate". J. Biol. Chem. 273 (23): 14081–4. PMID 9603905.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Milani D, Mazzoni M, Zauli G; et al. (1998). "HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells". AIDS. 12 (11): 1275–84. PMID 9708406.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jauliac S, Mazerolles F, Jabado N; et al. (1998). "Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity". Eur. J. Immunol. 28 (10): 3183–91. PMID 9808187.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brown RA, Domin J, Arcaro A; et al. (1999). "Insulin activates the alpha isoform of class II phosphoinositide 3-kinase". J. Biol. Chem. 274 (21): 14529–32. PMID 10329640.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Idriss H, Kawa S, Damuni Z; et al. (2000). "HIV-1 reverse transcriptase is phosphorylated in vitro and in a cellular system". Int. J. Biochem. Cell Biol. 31 (12): 1443–52. PMID 10641798.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Domin J, Gaidarov I, Smith ME; et al. (2000). "The class II phosphoinositide 3-kinase PI3K-C2alpha is concentrated in the trans-Golgi network and present in clathrin-coated vesicles". J. Biol. Chem. 275 (16): 11943–50. PMID 10766823.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Arcaro A, Zvelebil MJ, Wallasch C; et al. (2000). "Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors". Mol. Cell. Biol. 20 (11): 3817–30. PMID 10805725.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Park IW, Wang JF, Groopman JE (2001). "HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes". Blood. 97 (2): 352–8. PMID 11154208.CS1 maint: Multiple names: authors list (link)
• Zauli G, Milani D, Mirandola P; et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gaidarov I, Smith ME, Domin J, Keen JH (2001). "The class II phosphoinositide 3-kinase C2alpha is activated by clathrin and regulates clathrin-mediated membrane trafficking". Mol. Cell. 7 (2): 443–9. PMID 11239472.CS1 maint: Multiple names: authors list (link)
• Caldwell GM, Eddy RL, Day CD; et al. (2001). "Mapping of genes and transcribed sequences in a gene rich 400-kb region on human chromosome 11p15.1-->p14". Cytogenet. Cell Genet. 92 (1–2): 103–7. PMID 11306805.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Didichenko SA, Thelen M (2002). "Phosphatidylinositol 3-kinase c2alpha contains a nuclear localization sequence and associates with nuclear speckles". J. Biol. Chem. 276 (51): 48135–42. doi:10.1074/jbc.M104610200. PMID 11606566.
• Deregibus MC, Cantaluppi V, Doublier S; et al. (2002). "HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells". J. Biol. Chem. 277 (28): 25195–202. doi:10.1074/jbc.M200921200. PMID 11994280.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cook JA, August A, Henderson AJ (2002). "Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism". J. Immunol. 169 (1): 254–60. PMID 12077252.CS1 maint: Multiple names: authors list (link)