PPP2R1B

Protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform
Identifiers
Symbols	PPP2R1B ; MGC26454; PR65B
External IDs	Template:OMIM5 Template:MGI HomoloGene: 70244
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PPP2R1B 202884 s at tn.png
File:PBB GE PPP2R1B 222351 at tn.png
File:PBB GE PPP2R1B 202886 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform, also known as PPP2R1B, is a human gene.

This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Defects in this gene could be the cause of some lung and colon cancers. At least two transcript variants encoding different isoforms have been found for this gene.

Further reading

• Zolnierowicz S (2000). "Type 2A protein phosphatase, the complex regulator of numerous signaling pathways". Biochem. Pharmacol. 60 (8): 1225–35. PMID 11007961.
• Kamibayashi C, Lickteig RL, Estes R; et al. (1992). "Expression of the A subunit of protein phosphatase 2A and characterization of its interactions with the catalytic and regulatory subunits". J. Biol. Chem. 267 (30): 21864–72. PMID 1328247.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hemmings BA, Adams-Pearson C, Maurer F; et al. (1990). "alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure". Biochemistry. 29 (13): 3166–73. PMID 2159327.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tung HY, De Rocquigny H, Zhao LJ; et al. (1997). "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr". FEBS Lett. 401 (2–3): 197–201. PMID 9013886.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Adler HT, Nallaseth FS, Walter G, Tkachuk DC (1997). "HRX leukemic fusion proteins form a heterocomplex with the leukemia-associated protein SET and protein phosphatase 2A". J. Biol. Chem. 272 (45): 28407–14. PMID 9353299.CS1 maint: Multiple names: authors list (link)
• Ruediger R, Brewis N, Ohst K, Walter G (1998). "Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production". Virology. 238 (2): 432–43. doi:10.1006/viro.1997.8873. PMID 9400615.CS1 maint: Multiple names: authors list (link)
• Wang SS, Esplin ED, Li JL; et al. (1998). "Alterations of the PPP2R1B gene in human lung and colon cancer". Science. 282 (5387): 284–7. PMID 9765152.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Baysal BE, Farr JE, Goss JR; et al. (1998). "Genomic organization and precise physical location of protein phosphatase 2A regulatory subunit A beta isoform gene on chromosome band 11q23". Gene. 217 (1–2): 107–16. PMID 9795170.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takahashi M, Shibata H, Shimakawa M; et al. (1999). "Characterization of a novel giant scaffolding protein, CG-NAP, that anchors multiple signaling enzymes to centrosome and the golgi apparatus". J. Biol. Chem. 274 (24): 17267–74. PMID 10358086.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Campbell IG, Manolitsas T (2000). "Absence of PPP2R1B gene alterations in primary ovarian cancers". Oncogene. 18 (46): 6367–9. doi:10.1038/sj.onc.1203070. PMID 10597236.
• Takagi Y, Futamura M, Yamaguchi K; et al. (2000). "Alterations of the PPP2R1B gene located at 11q23 in human colorectal cancers". Gut. 47 (2): 268–71. PMID 10896920.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hrimech M, Yao XJ, Branton PE, Cohen EA (2000). "Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A". EMBO J. 19 (15): 3956–67. doi:10.1093/emboj/19.15.3956. PMID 10921877.CS1 maint: Multiple names: authors list (link)
• Baysal BE, Willett-Brozick JE, Taschner PE; et al. (2001). "A high-resolution integrated map spanning the SDHD gene at 11q23: a 1.1-Mb BAC contig, a partial transcript map and 15 new repeat polymorphisms in a tumour-suppressor region". Eur. J. Hum. Genet. 9 (2): 121–9. doi:10.1038/sj.ejhg.5200585. PMID 11313745.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ruediger R, Pham HT, Walter G (2001). "Alterations in protein phosphatase 2A subunit interaction in human carcinomas of the lung and colon with mutations in the A beta subunit gene". Oncogene. 20 (15): 1892–9. doi:10.1038/sj.onc.1204279. PMID 11313937.CS1 maint: Multiple names: authors list (link)
• Yokoyama N, Reich NC, Miller WT (2001). "Involvement of protein phosphatase 2A in the interleukin-3-stimulated Jak2-Stat5 signaling pathway". J. Interferon Cytokine Res. 21 (6): 369–78. doi:10.1089/107999001750277844. PMID 11440634.CS1 maint: Multiple names: authors list (link)
• Elder RT, Yu M, Chen M; et al. (2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID 11531413.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang J, Fan GH, Wadzinski BE; et al. (2002). "Protein phosphatase 2A interacts with and directly dephosphorylates RelA". J. Biol. Chem. 276 (51): 47828–33. doi:10.1074/jbc.M106103200. PMID 11591705.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strack S, Ruediger R, Walter G; et al. (2002). "Protein phosphatase 2A holoenzyme assembly: identification of contacts between B-family regulatory and scaffolding A subunits". J. Biol. Chem. 277 (23): 20750–5. doi:10.1074/jbc.M202992200. PMID 11929880.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hemmer S, Wasenius VM, Haglund C; et al. (2002). "Alterations in the suppressor gene PPP2R1B in parathyroid hyperplasias and adenomas". Cancer Genet. Cytogenet. 134 (1): 13–7. PMID 11996789.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)