NNMT

Nicotinamide N-methyltransferase
File:PBB Protein NNMT image.jpg PDB rendering based on 2iip.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2iip​
Identifiers
Symbols	NNMT ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4496
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE NNMT 202237 at tn.png
File:PBB GE NNMT 202238 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Nicotinamide N-methyltransferase, also known as NNMT, is a human gene.

N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor.

Further reading

• Williams AC, Cartwright LS, Ramsden DB (2005). "Parkinson's disease: the first common neurological disease due to auto-intoxication?". QJM : monthly journal of the Association of Physicians. 98 (3): 215–26. doi:10.1093/qjmed/hci027. PMID 15728403.CS1 maint: Multiple names: authors list (link)
• Sano A, Endo N, Takitani S (1992). "Fluorometric assay of rat tissue N-methyltransferases with nicotinamide and four isomeric methylnicotinamides". Chem. Pharm. Bull. 40 (1): 153–6. PMID 1533573.CS1 maint: Multiple names: authors list (link)
• Aksoy S, Szumlanski CL, Weinshilboum RM (1994). "Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization". J. Biol. Chem. 269 (20): 14835–40. PMID 8182091.CS1 maint: Multiple names: authors list (link)
• Aksoy S, Brandriff BF, Ward A; et al. (1996). "Human nicotinamide N-methyltransferase gene: molecular cloning, structural characterization and chromosomal localization". Genomics. 29 (3): 555–61. doi:10.1006/geno.1995.9966. PMID 8575745.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scheller T, Orgacka H, Szumlanski CL, Weinshilboum RM (1996). "Mouse liver nicotinamide N-methyltransferase pharmacogenetics: biochemical properties and variation in activity among inbred strains". Pharmacogenetics. 6 (1): 43–53. PMID 8845860.CS1 maint: Multiple names: authors list (link)
• Smith ML, Burnett D, Bennett P; et al. (1998). "A direct correlation between nicotinamide N-methyltransferase activity and protein levels in human liver cytosol". Biochim. Biophys. Acta. 1442 (2–3): 238–44. PMID 9804963.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yan L, Otterness DM, Weinshilboum RM (1999). "Human nicotinamide N-methyltransferase pharmacogenetics: gene sequence analysis and promoter characterization". Pharmacogenetics. 9 (3): 307–16. PMID 10471062.CS1 maint: Multiple names: authors list (link)
• Hubbard MJ, McHugh NJ (2001). "Human ERp29: isolation, primary structural characterisation and two-dimensional gel mapping". Electrophoresis. 21 (17): 3785–96. doi:10.1002/1522-2683(200011)21:17<3785::AID-ELPS3785>3.0.CO;2-2. PMID 11271497.
• Parsons RB, Smith ML, Williams AC; et al. (2002). "Expression of nicotinamide N-methyltransferase (E.C. 2.1.1.1) in the Parkinsonian brain". J. Neuropathol. Exp. Neurol. 61 (2): 111–24. PMID 11853016.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kassem HSh, Sangar V, Cowan R; et al. (2002). "A potential role of heat shock proteins and nicotinamide N-methyl transferase in predicting response to radiation in bladder cancer". Int. J. Cancer. 101 (5): 454–60. doi:10.1002/ijc.10631. PMID 12216074.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xu J, Capezzone M, Xu X, Hershman JM (2005). "Activation of nicotinamide N-methyltransferase gene promoter by hepatocyte nuclear factor-1beta in human papillary thyroid cancer cells". Mol. Endocrinol. 19 (2): 527–39. doi:10.1210/me.2004-0215. PMID 15486044.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Souto JC, Blanco-Vaca F, Soria JM; et al. (2005). "A genomewide exploration suggests a new candidate gene at chromosome 11q23 as the major determinant of plasma homocysteine levels: results from the GAIT project". Am. J. Hum. Genet. 76 (6): 925–33. doi:10.1086/430409. PMID 15849667.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Roessler M, Rollinger W, Palme S; et al. (2005). "Identification of nicotinamide N-methyltransferase as a novel serum tumor marker for colorectal cancer". Clin. Cancer Res. 11 (18): 6550–7. doi:10.1158/1078-0432.CCR-05-0983. PMID 16166432.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xu J, Hershman JM (2006). "Histone deacetylase inhibitor depsipeptide represses nicotinamide N-methyltransferase and hepatocyte nuclear factor-1beta gene expression in human papillary thyroid cancer cells". Thyroid. 16 (2): 151–60. PMID 16676400.