MADD (gene)

MAP-kinase activating death domain
Identifiers
Symbols	MADD ; DENN; IG20; KIAA0358; RAB3GEP
External IDs	Template:OMIM5 Template:MGI HomoloGene: 14249
Gene ontology
RNA expression pattern
File:PBB GE MADD 38398 at tn.png
File:PBB GE MADD 210252 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

MAP-kinase activating death domain, also known as MADD, is a human gene.

Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene.

Further reading

• Chow VT, Lee SS (1997). "DENN, a novel human gene differentially expressed in normal and neoplastic cells". DNA Seq. 6 (5): 263–73. PMID 8988362.
• Schievella AR, Chen JH, Graham JR, Lin LL (1997). "MADD, a novel death domain protein that interacts with the type 1 tumor necrosis factor receptor and activates mitogen-activated protein kinase". J. Biol. Chem. 272 (18): 12069–75. PMID 9115275.CS1 maint: Multiple names: authors list (link)
• Nagase T, Ishikawa K, Nakajima D; et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. PMID 9205841.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang Y, Zhou L, Miller CA (1998). "A splicing variant of a death domain protein that is regulated by a mitogen-activated kinase is a substrate for c-Jun N-terminal kinase in the human central nervous system". Proc. Natl. Acad. Sci. U.S.A. 95 (5): 2586–91. PMID 9482930.CS1 maint: Multiple names: authors list (link)
• Chow VT, Lim KM, Lim D (1998). "The human DENN gene: genomic organization, alternative splicing, and localization to chromosome 11p11.21-p11.22". Genome. 41 (4): 543–52. PMID 9796103.CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Ishihara D, Sasaki M; et al. (2000). "Statistical analysis of the 5' untranslated region of human mRNA using "Oligo-Capped" cDNA libraries". Genomics. 64 (3): 286–97. doi:10.1006/geno.2000.6076. PMID 10756096.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Telliez JB, Bean KM, Lin LL (2000). "LRDD, a novel leucine rich repeat and death domain containing protein". Biochim. Biophys. Acta. 1478 (2): 280–8. PMID 10825539.CS1 maint: Multiple names: authors list (link)
• Iwasaki K, Toyonaga R (2000). "The Rab3 GDP/GTP exchange factor homolog AEX-3 has a dual function in synaptic transmission". EMBO J. 19 (17): 4806–16. doi:10.1093/emboj/19.17.4806. PMID 10970871.
• Al-Zoubi AM, Efimova EV, Kaithamana S; et al. (2002). "Contrasting effects of IG20 and its splice isoforms, MADD and DENN-SV, on tumor necrosis factor alpha-induced apoptosis and activation of caspase-8 and -3". J. Biol. Chem. 276 (50): 47202–11. doi:10.1074/jbc.M104835200. PMID 11577081.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lim KM, Chow VT (2002). "Induction of marked apoptosis in mammalian cancer cell lines by antisense DNA treatment to abolish expression of DENN (differentially expressed in normal and neoplastic cells)". Mol. Carcinog. 35 (3): 110–26. doi:10.1002/mc.10082. PMID 12410563.
• Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMID 12421765.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Efimova E, Martinez O, Lokshin A; et al. (2004). "IG20, a MADD splice variant, increases cell susceptibility to gamma-irradiation and induces soluble mediators that suppress tumor cell growth". Cancer Res. 63 (24): 8768–76. PMID 14695193.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Efimova EV, Al-Zoubi AM, Martinez O; et al. (2004). "IG20, in contrast to DENN-SV, (MADD splice variants) suppresses tumor cell survival, and enhances their susceptibility to apoptosis and cancer drugs". Oncogene. 23 (5): 1076–87. doi:10.1038/sj.onc.1207210. PMID 14716293.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lim KM, Yeo WS, Chow VT (2004). "Antisense abrogation of DENN expression induces apoptosis of leukemia cells in vitro, causes tumor regression in vivo and alters the transcription of genes involved in apoptosis and the cell cycle". Int. J. Cancer. 109 (1): 24–37. doi:10.1002/ijc.11660. PMID 14735464.CS1 maint: Multiple names: authors list (link)
• Del Villar K, Miller CA (2004). "Down-regulation of DENN/MADD, a TNF receptor binding protein, correlates with neuronal cell death in Alzheimer's disease brain and hippocampal neurons". Proc. Natl. Acad. Sci. U.S.A. 101 (12): 4210–5. doi:10.1073/pnas.0307349101. PMID 15007167.
• Xu Y, Kulkosky J, Acheampong E; et al. (2004). "HIV-1-mediated apoptosis of neuronal cells: Proximal molecular mechanisms of HIV-1-induced encephalopathy". Proc. Natl. Acad. Sci. U.S.A. 101 (18): 7070–5. doi:10.1073/pnas.0304859101. PMID 15103018.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ramaswamy M, Efimova EV, Martinez O; et al. (2005). "IG20 (MADD splice variant-5), a proapoptotic protein, interacts with DR4/DR5 and enhances TRAIL-induced apoptosis by increasing recruitment of FADD and caspase-8 to the DISC". Oncogene. 23 (36): 6083–94. doi:10.1038/sj.onc.1207804. PMID 15208670.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hu YF, Zhang HL, Cai T; et al. (2006). "The IA-2 interactome". Diabetologia. 48 (12): 2576–81. doi:10.1007/s00125-005-0037-y. PMID 16273344.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)