TUBA1A
| Tubulin, alpha 1a | |||||||||||||
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File:PBB Protein TUBA1A image.jpg PDB rendering based on 1ffx. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | TUBA1A ; B-ALPHA-1; FLJ25113; TUBA3 | ||||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 68498 | ||||||||||||
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| RNA expression pattern | |||||||||||||
| File:PBB GE TUBA1A 209118 s at tn.png | |||||||||||||
| File:PBB GE TUBA1A 201090 x at tn.png | |||||||||||||
| File:PBB GE TUBA1A 209251 x at tn.png | |||||||||||||
| More reference expression data | |||||||||||||
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| Template:GNF Ortholog box | |||||||||||||
| Species | Human | Mouse | |||||||||||
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Tubulin, alpha 1a, also known as TUBA1A, is a human gene.[1]
Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to mouse and rat Tuba1 gene. Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q.[1]
References
Further reading
- Desai A, Mitchison TJ (1998). "Tubulin and FtsZ structures: functional and therapeutic implications". Bioessays. 20 (7): 523–7. doi:10.1002/(SICI)1521-1878(199807)20:7<523::AID-BIES1>3.0.CO;2-L. PMID 9722999.
- Oakley BR (2001). "An abundance of tubulins". Trends Cell Biol. 10 (12): 537–42. PMID 11121746.
- Dutcher SK (2001). "The tubulin fraternity: alpha to eta". Curr. Opin. Cell Biol. 13 (1): 49–54. PMID 11163133.
- Miller FD, Naus CC, Durand M; et al. (1988). "Isotypes of alpha-tubulin are differentially regulated during neuronal maturation". J. Cell Biol. 105 (6 Pt 2): 3065–73. PMID 3693406.
- Hall JL, Cowan NJ (1985). "Structural features and restricted expression of a human alpha-tubulin gene". Nucleic Acids Res. 13 (1): 207–23. PMID 3839072.
- Cowan NJ, Dobner PR, Fuchs EV, Cleveland DW (1984). "Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions". Mol. Cell. Biol. 3 (10): 1738–45. PMID 6646120.
- Alexandrova N, Niklinski J, Bliskovsky V; et al. (1995). "The N-terminal domain of c-Myc associates with alpha-tubulin and microtubules in vivo and in vitro". Mol. Cell. Biol. 15 (9): 5188–95. PMID 7651436.
- Sapir T, Elbaum M, Reiner O (1998). "Reduction of microtubule catastrophe events by LIS1, platelet-activating factor acetylhydrolase subunit". EMBO J. 16 (23): 6977–84. doi:10.1093/emboj/16.23.6977. PMID 9384577.
- Kinnunen T, Kaksonen M, Saarinen J; et al. (1998). "Cortactin-Src kinase signaling pathway is involved in N-syndecan-dependent neurite outgrowth". J. Biol. Chem. 273 (17): 10702–8. PMID 9553134.
- Faruki S, Geahlen RL, Asai DJ (2000). "Syk-dependent phosphorylation of microtubules in activated B-lymphocytes". J. Cell. Sci. 113 ( Pt 14): 2557–65. PMID 10862713.
- Watts NR, Sackett DL, Ward RD; et al. (2000). "HIV-1 rev depolymerizes microtubules to form stable bilayered rings". J. Cell Biol. 150 (2): 349–60. PMID 10908577.
- Germani A, Bruzzoni-Giovanelli H, Fellous A; et al. (2001). "SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis". Oncogene. 19 (52): 5997–6006. doi:10.1038/sj.onc.1204002. PMID 11146551.
- Crabtree DV, Ojima I, Geng X, Adler AJ (2001). "Tubulins in the primate retina: evidence that xanthophylls may be endogenous ligands for the paclitaxel-binding site". Bioorg. Med. Chem. 9 (8): 1967–76. PMID 11504633.
- Payton JE, Perrin RJ, Clayton DF, George JM (2002). "Protein-protein interactions of alpha-synuclein in brain homogenates and transfected cells". Brain Res. Mol. Brain Res. 95 (1–2): 138–45. PMID 11687285.
- Bifulco M, Laezza C, Stingo S, Wolff J (2002). "2',3'-Cyclic nucleotide 3'-phosphodiesterase: a membrane-bound, microtubule-associated protein and membrane anchor for tubulin". Proc. Natl. Acad. Sci. U.S.A. 99 (4): 1807–12. doi:10.1073/pnas.042678799. PMID 11842207.
- Saugstad JA, Yang S, Pohl J; et al. (2002). "Interaction between metabotropic glutamate receptor 7 and alpha tubulin". J. Neurochem. 80 (6): 980–8. PMID 11953448.
- Ivings L, Pennington SR, Jenkins R; et al. (2002). "Identification of Ca2+-dependent binding partners for the neuronal calcium sensor protein neurocalcin delta: interaction with actin, clathrin and tubulin". Biochem. J. 363 (Pt 3): 599–608. PMID 11964161.