ITGA7

Integrin, alpha 7
Identifiers
Symbols	ITGA7 ; FLJ25220
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37592
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE ITGA7 216331 at tn.png
File:PBB GE ITGA7 209663 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Integrin, alpha 7, also known as ITGA7, is a human gene.

ITGA7 encodes integrin alpha chain 7. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 7 undergoes post-translational cleavage within the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that binds to the extracellular matrix protein laminin-1. Alpha 7 beta 1 is the major integrin complex expressed in differentiated muscle cells. Splice variants of alpha 7 that differ in both the extracellular and cytoplasmic domains exist in the mouse; however, to date only a single human transcript type has been isolated: it contains extracellular and cytoplasmic domains corresponding to the mouse X2 and B variants, respectively. A unique extracellular splice variant has been identified in human, although it clearly represents a minor species and its biological significance is unclear.

Further reading

• Fornaro M, Languino LR (1998). "Alternatively spliced variants: a new view of the integrin cytoplasmic domain". Matrix Biol. 16 (4): 185–93. PMID 9402008.
• Song WK, Wang W, Foster RF; et al. (1992). "H36-alpha 7 is a novel integrin alpha chain that is developmentally regulated during skeletal myogenesis". J. Cell Biol. 117 (3): 643–57. PMID 1315319.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kramer RH, Vu MP, Cheng YF; et al. (1992). "Laminin-binding integrin alpha 7 beta 1: functional characterization and expression in normal and malignant melanocytes". Cell Regul. 2 (10): 805–17. PMID 1839357.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang W, Wu W, Desai T; et al. (1995). "Localization of the alpha 7 integrin gene (ITGA7) on human chromosome 12q13: clustering of integrin and Hox genes implies parallel evolution of these gene families". Genomics. 26 (3): 568–70. PMID 7607681.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Song WK, Wang W, Sato H; et al. (1994). "Expression of alpha 7 integrin cytoplasmic domains during skeletal muscle development: alternate forms, conformational change, and homologies with serine/threonine kinases and tyrosine phosphatases". J. Cell. Sci. 106 ( Pt 4): 1139–52. PMID 8126096.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ziober BL, Vu MP, Waleh N; et al. (1994). "Alternative extracellular and cytoplasmic domains of the integrin alpha 7 subunit are differentially expressed during development". J. Biol. Chem. 268 (35): 26773–83. PMID 8253814.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Martin PT, Kaufman SJ, Kramer RH, Sanes JR (1996). "Synaptic integrins in developing, adult, and mutant muscle: selective association of alpha1, alpha7A, and alpha7B integrins with the neuromuscular junction". Dev. Biol. 174 (1): 125–39. doi:10.1006/dbio.1996.0057. PMID 8626012.CS1 maint: Multiple names: authors list (link)
• Ziober BL, Chen Y, Kramer RH (1997). "The laminin-binding activity of the alpha 7 integrin receptor is defined by developmentally regulated splicing in the extracellular domain". Mol. Biol. Cell. 8 (9): 1723–34. PMID 9307969.CS1 maint: Multiple names: authors list (link)
• Basora N, Vachon PH, Herring-Gillam FE; et al. (1997). "Relation between integrin alpha7Bbeta1 expression in human intestinal cells and enterocytic differentiation". Gastroenterology. 113 (5): 1510–21. PMID 9352853.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mayer U, Saher G, Fässler R; et al. (1997). "Absence of integrin alpha 7 causes a novel form of muscular dystrophy". Nat. Genet. 17 (3): 318–23. doi:10.1038/ng1197-318. PMID 9354797.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Leung E, Lim SP, Berg R; et al. (1998). "A novel extracellular domain variant of the human integrin alpha 7 subunit generated by alternative intron splicing". Biochem. Biophys. Res. Commun. 243 (1): 317–25. doi:10.1006/bbrc.1998.8092. PMID 9473524.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zolkiewska A, Thompson WC, Moss J (1998). "Interaction of integrin alpha 7 beta 1 in C2C12 myotubes and in solution with laminin". Exp. Cell Res. 240 (1): 86–94. doi:10.1006/excr.1998.4002. PMID 9570924.CS1 maint: Multiple names: authors list (link)
• Hayashi YK, Chou FL, Engvall E; et al. (1998). "Mutations in the integrin alpha7 gene cause congenital myopathy". Nat. Genet. 19 (1): 94–7. doi:10.1038/ng0598-94. PMID 9590299.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vignier N, Moghadaszadeh B, Gary F; et al. (1999). "Structure, genetic localization, and identification of the cardiac and skeletal muscle transcripts of the human integrin alpha7 gene (ITGA7)". Biochem. Biophys. Res. Commun. 260 (2): 357–64. doi:10.1006/bbrc.1999.0916. PMID 10403775.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tachibana I, Hemler ME (1999). "Role of transmembrane 4 superfamily (TM4SF) proteins CD9 and CD81 in muscle cell fusion and myotube maintenance". J. Cell Biol. 146 (4): 893–904. PMID 10459022.
• Schöber S, Mielenz D, Echtermeyer F; et al. (2000). "The role of extracellular and cytoplasmic splice domains of alpha7-integrin in cell adhesion and migration on laminins". Exp. Cell Res. 255 (2): 303–13. doi:10.1006/excr.2000.4806. PMID 10694445.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wixler V, Geerts D, Laplantine E; et al. (2000). "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes". J. Biol. Chem. 275 (43): 33669–78. doi:10.1074/jbc.M002519200. PMID 10906324.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Burkin DJ, Kim JE, Gu M, Kaufman SJ (2000). "Laminin and alpha7beta1 integrin regulate agrin-induced clustering of acetylcholine receptors". J. Cell. Sci. 113 ( Pt 16): 2877–86. PMID 10910772.CS1 maint: Multiple names: authors list (link)
• Vizirianakis IS, Yao CC, Chen Y; et al. (2001). "Transfection of MCF-7 carcinoma cells with human integrin alpha7 cDNA promotes adhesion to laminin". Arch. Biochem. Biophys. 385 (1): 108–16. doi:10.1006/abbi.2000.2134. PMID 11361006.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)