EPS8

Epidermal growth factor receptor pathway substrate 8
PDB rendering based on 1aoj.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1aoj​, 1i07​, 1i0c​
Identifiers
Symbols	EPS8 ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3272
Gene ontology Molecular function Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Epidermal growth factor receptor pathway substrate 8, also known as EPS8, is a human gene.

This gene encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor-mediated actin remodeling. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Further reading

• Di Fiore PP, Scita G (2002). "Eps8 in the midst of GTPases". Int. J. Biochem. Cell Biol. 34 (10): 1178–83. PMID 12127568.
• Cardwell C (1977). "Student or worker? International Meeting of Student Nurses (European Group)". Nursing mirror and midwives journal. 143 (19): 38. PMID 1049958.
• Castagnino P, Biesova Z, Wong WT; et al. (1995). "Direct binding of eps8 to the juxtamembrane domain of EGFR is phosphotyrosine- and SH2-independent". Oncogene. 10 (4): 723–9. PMID 7532293.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Karlsson T, Songyang Z, Landgren E; et al. (1995). "Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins". Oncogene. 10 (8): 1475–83. PMID 7537362.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Avantaggiato V, Torino A, Wong WT; et al. (1995). "Expression of the receptor tyrosine kinase substrate genes eps8 and eps15 during mouse development". Oncogene. 11 (6): 1191–8. PMID 7566980.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Matoskova B, Wong WT, Salcini AE; et al. (1995). "Constitutive phosphorylation of eps8 in tumor cell lines: relevance to malignant transformation". Mol. Cell. Biol. 15 (7): 3805–12. PMID 7791787.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wong WT, Carlomagno F, Druck T; et al. (1994). "Evolutionary conservation of the EPS8 gene and its mapping to human chromosome 12q23-q24". Oncogene. 9 (10): 3057–61. PMID 8084614.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fazioli F, Minichiello L, Matoska V; et al. (1993). "Eps8, a substrate for the epidermal growth factor receptor kinase, enhances EGF-dependent mitogenic signals". EMBO J. 12 (10): 3799–808. PMID 8404850.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Matòsková B, Wong WT, Seki N; et al. (1996). "RN-tre identifies a family of tre-related proteins displaying a novel potential protein binding domain". Oncogene. 12 (12): 2563–71. PMID 8700515.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Matòsková B, Wong WT, Nomura N; et al. (1996). "RN-tre specifically binds to the SH3 domain of eps8 with high affinity and confers growth advantage to NIH3T3 upon carboxy-terminal truncation". Oncogene. 12 (12): 2679–88. PMID 8700527.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Biesova Z, Piccoli C, Wong WT (1997). "Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth". Oncogene. 14 (2): 233–41. doi:10.1038/sj.onc.1200822. PMID 9010225.CS1 maint: Multiple names: authors list (link)
• Kishan KV, Scita G, Wong WT; et al. (1997). "The SH3 domain of Eps8 exists as a novel intertwined dimer". Nat. Struct. Biol. 4 (9): 739–43. PMID 9303002.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maa MC, Lai JR, Lin RW, Leu TH (1999). "Enhancement of tyrosyl phosphorylation and protein expression of eps8 by v-Src". Biochim. Biophys. Acta. 1450 (3): 341–51. PMID 10395945.CS1 maint: Multiple names: authors list (link)
• Scita G, Nordstrom J, Carbone R; et al. (1999). "EPS8 and E3B1 transduce signals from Ras to Rac". Nature. 401 (6750): 290–3. doi:10.1038/45822. PMID 10499589.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Inobe M, Katsube K, Miyagoe Y; et al. (2000). "Identification of EPS8 as a Dvl1-associated molecule". Biochem. Biophys. Res. Commun. 266 (1): 216–21. doi:10.1006/bbrc.1999.1782. PMID 10581192.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lanzetti L, Rybin V, Malabarba MG; et al. (2000). "The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5". Nature. 408 (6810): 374–7. doi:10.1038/35042605. PMID 11099046.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ion A, Crosby AH, Kremer H; et al. (2000). "Detailed mapping, mutation analysis, and intragenic polymorphism identification in candidate Noonan syndrome genes MYL2, DCN, EPS8, and RPL6". J. Med. Genet. 37 (11): 884–6. PMID 11185075.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scita G, Tenca P, Areces LB; et al. (2001). "An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin-polymerizing machine". J. Cell Biol. 154 (5): 1031–44. doi:10.1083/jcb.200103146. PMID 11524436.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)