CLEC7A

C-type lectin domain family 7, member A
Identifiers
Symbols	CLEC7A ; BGR; CLECSF12; DECTIN1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 49606
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

C-type lectin domain family 7, member A, also known as CLEC7A, is a human gene.

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.

Further reading

• Drickamer K (1999). "C-type lectin-like domains". Curr. Opin. Struct. Biol. 9 (5): 585–90. PMID 10508765.
• Brown GD (2006). "Dectin-1: a signalling non-TLR pattern-recognition receptor". Nat. Rev. Immunol. 6 (1): 33–43. doi:10.1038/nri1745. PMID 16341139.
• Adams MD, Kerlavage AR, Fleischmann RD; et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence". Nature. 377 (6547 Suppl): 3–174. PMID 7566098.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ariizumi K, Shen GL, Shikano S; et al. (2000). "Identification of a novel, dendritic cell-associated molecule, dectin-1, by subtractive cDNA cloning". J. Biol. Chem. 275 (26): 20157–67. doi:10.1074/jbc.M909512199. PMID 10779524.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yokota K, Takashima A, Bergstresser PR, Ariizumi K (2001). "Identification of a human homologue of the dendritic cell-associated C-type lectin-1, dectin-1". Gene. 272 (1–2): 51–60. PMID 11470510.CS1 maint: Multiple names: authors list (link)
• Hermanz-Falcón P, Arce I, Roda-Navarro P, Fernández-Ruiz E (2001). "Cloning of human DECTIN-1, a novel C-type lectin-like receptor gene expressed on dendritic cells". Immunogenetics. 53 (4): 288–95. PMID 11491532.CS1 maint: Multiple names: authors list (link)
• Brown GD, Gordon S (2001). "Immune recognition. A new receptor for beta-glucans". Nature. 413 (6851): 36–7. doi:10.1038/35092620. PMID 11544516.
• Willment JA, Gordon S, Brown GD (2001). "Characterization of the human beta -glucan receptor and its alternatively spliced isoforms". J. Biol. Chem. 276 (47): 43818–23. doi:10.1074/jbc.M107715200. PMID 11567029.CS1 maint: Multiple names: authors list (link)
• Sobanov Y, Bernreiter A, Derdak S; et al. (2002). "A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex". Eur. J. Immunol. 31 (12): 3493–503. PMID 11745369.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Grünebach F, Weck MM, Reichert J, Brossart P (2002). "Molecular and functional characterization of human Dectin-1". Exp. Hematol. 30 (11): 1309–15. PMID 12423684.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ahrén IL, Eriksson E, Egesten A, Riesbeck K (2003). "Nontypeable Haemophilus influenzae activates human eosinophils through beta-glucan receptors". Am. J. Respir. Cell Mol. Biol. 29 (5): 598–605. doi:10.1165/rcmb.2002-0138OC. PMID 12689921.CS1 maint: Multiple names: authors list (link)
• Ebner S, Sharon N, Ben-Tal N (2003). "Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily". Proteins. 53 (1): 44–55. doi:10.1002/prot.10440. PMID 12945048.CS1 maint: Multiple names: authors list (link)
• Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Taylor PR, Brown GD, Herre J; et al. (2004). "The role of SIGNR1 and the beta-glucan receptor (dectin-1) in the nonopsonic recognition of yeast by specific macrophages". J. Immunol. 172 (2): 1157–62. PMID 14707091.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mantegazza AR, Barrio MM, Moutel S; et al. (2005). "CD63 tetraspanin slows down cell migration and translocates to the endosomal-lysosomal-MIICs route after extracellular stimuli in human immature dendritic cells". Blood. 104 (4): 1183–90. doi:10.1182/blood-2004-01-0104. PMID 15130945.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• de la Rosa G, Yáñez-Mó M, Samaneigo R; et al. (2005). "Regulated recruitment of DC-SIGN to cell-cell contact regions during zymosan-induced human dendritic cell aggregation". J. Leukoc. Biol. 77 (5): 699–709. doi:10.1189/jlb.0904529. PMID 15728245.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Willment JA, Marshall AS, Reid DM; et al. (2005). "The human beta-glucan receptor is widely expressed and functionally equivalent to murine Dectin-1 on primary cells". Eur. J. Immunol. 35 (5): 1539–47. doi:10.1002/eji.200425725. PMID 15816015.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)