MMP19

Matrix metallopeptidase 19
Identifiers
Symbols	MMP19 ; MMP18; RASI-1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1820
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Matrix metallopeptidase 19, also known as MMP19, is a human gene.

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This protein is expressed in human epidermis and it has a role in cellular proliferation as well as migration and adhesion to type I collagen. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

Further reading

• Murphy G, Knäuper V, Cowell S; et al. (1999). "Evaluation of some newer matrix metalloproteinases". Ann. N. Y. Acad. Sci. 878: 25–39. PMID 10415718.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagase H, Woessner JF (1999). "Matrix metalloproteinases". J. Biol. Chem. 274 (31): 21491–4. PMID 10419448.
• Fosang AJ, Last K, Neame PJ; et al. (1995). "Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan". Biochem. J. 304 ( Pt 2): 347–51. PMID 7998967.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Fosang AJ, Last K, Knäuper V; et al. (1993). "Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain". Biochem. J. 295 ( Pt 1): 273–6. PMID 8216228.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cossins J, Dudgeon TJ, Catlin G; et al. (1996). "Identification of MMP-18, a putative novel human matrix metalloproteinase". Biochem. Biophys. Res. Commun. 228 (2): 494–8. doi:10.1006/bbrc.1996.1688. PMID 8920941.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pendás AM, Knäuper V, Puente XS; et al. (1997). "Identification and characterization of a novel human matrix metalloproteinase with unique structural characteristics, chromosomal location, and tissue distribution". J. Biol. Chem. 272 (7): 4281–6. PMID 9020145.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kolb C, Mauch S, Peter HH; et al. (1997). "The matrix metalloproteinase RASI-1 is expressed in synovial blood vessels of a rheumatoid arthritis patient". Immunol. Lett. 57 (1–3): 83–8. PMID 9232430.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sedlacek R, Mauch S, Kolb B; et al. (1998). "Matrix metalloproteinase MMP-19 (RASI-1) is expressed on the surface of activated peripheral blood mononuclear cells and is detected as an autoantigen in rheumatoid arthritis". Immunobiology. 198 (4): 408–23. PMID 9562866.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fosang AJ, Last K, Fujii Y; et al. (1998). "Membrane-type 1 MMP (MMP-14) cleaves at three sites in the aggrecan interglobular domain". FEBS Lett. 430 (3): 186–90. PMID 9688535.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stracke JO, Hutton M, Stewart M; et al. (2000). "Biochemical characterization of the catalytic domain of human matrix metalloproteinase 19. Evidence for a role as a potent basement membrane degrading enzyme". J. Biol. Chem. 275 (20): 14809–16. PMID 10809722.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mueller MS, Mauch S, Sedlacek R (2000). "Structure of the human MMP-19 gene". Gene. 252 (1–2): 27–37. PMID 10903435.CS1 maint: Multiple names: authors list (link)
• Stracke JO, Fosang AJ, Last K; et al. (2000). "Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP)". FEBS Lett. 478 (1–2): 52–6. PMID 10922468.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Terp GE, Christensen IT, Jørgensen FS (2000). "Structural differences of matrix metalloproteinases. Homology modeling and energy minimization of enzyme-substrate complexes". J. Biomol. Struct. Dyn. 17 (6): 933–46. PMID 10949161.CS1 maint: Multiple names: authors list (link)
• Mauch S, Kolb C, Kolb B; et al. (2002). "Matrix metalloproteinase-19 is expressed in myeloid cells in an adhesion-dependent manner and associates with the cell surface". J. Immunol. 168 (3): 1244–51. PMID 11801661.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rodríguez-Manzaneque JC, Westling J, Thai SN; et al. (2002). "ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors". Biochem. Biophys. Res. Commun. 293 (1): 501–8. doi:10.1016/S0006-291X(02)00254-1. PMID 12054629.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)