CAMKK2

Calcium/calmodulin-dependent protein kinase kinase 2, beta
Identifiers
Symbols	CAMKK2 ; CAMKK; CAMKKB; KIAA0787; MGC15254
External IDs	Template:MGI HomoloGene: 32756
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Calcium/calmodulin-dependent protein kinase kinase 2, beta, also known as CAMKK2, is a human gene.

The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Seven transcript variants encoding six distinct isoforms have been identified for this gene. Additional splice variants have been described but their full-length nature has not been determined. The identified isoforms exhibit a distinct ability to undergo autophosphorylation and to phosphorylate the downstream kinases.

Further reading

• Nakajima D, Okazaki N, Yamakawa H; et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. PMID 12168954.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hsu LS, Tsou AP, Chi CW; et al. (1998). "Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase". J. Biomed. Sci. 5 (2): 141–9. PMID 9662074.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Anderson KA, Means RL, Huang QH; et al. (1998). "Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta". J. Biol. Chem. 273 (48): 31880–9. PMID 9822657.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagase T, Ishikawa K, Suyama M; et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. PMID 9872452.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hsu LS, Chen GD, Lee LS; et al. (2001). "Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity". J. Biol. Chem. 276 (33): 31113–23. doi:10.1074/jbc.M011720200. PMID 11395482.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Imai S, Okayama N, Shimizu M, Itoh M (2003). "Increased intracellular calcium activates serum and glucocorticoid-inducible kinase 1 (SGK1) through a calmodulin-calcium calmodulin dependent kinase kinase pathway in Chinese hamster ovary cells". Life Sci. 72 (20): 2199–209. PMID 12628440.CS1 maint: Multiple names: authors list (link)
• Ishikawa Y, Tokumitsu H, Inuzuka H; et al. (2003). "Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells". FEBS Lett. 550 (1–3): 57–63. PMID 12935886.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hawley SA, Pan DA, Mustard KJ; et al. (2005). "Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase". Cell Metab. 2 (1): 9–19. doi:10.1016/j.cmet.2005.05.009. PMID 16054095.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Woods A, Dickerson K, Heath R; et al. (2005). "Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells". Cell Metab. 2 (1): 21–33. doi:10.1016/j.cmet.2005.06.005. PMID 16054096.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Novak G, Seeman P, Tallerico T (2006). "Increased expression of calcium/calmodulin-dependent protein kinase IIbeta in frontal cortex in schizophrenia and depression". Synapse. 59 (1): 61–8. doi:10.1002/syn.20211. PMID 16247765.CS1 maint: Multiple names: authors list (link)
• Stahmann N, Woods A, Carling D, Heller R (2006). "Thrombin activates AMP-activated protein kinase in endothelial cells via a pathway involving Ca2+/calmodulin-dependent protein kinase kinase beta". Mol. Cell. Biol. 26 (16): 5933–45. doi:10.1128/MCB.00383-06. PMID 16880506.CS1 maint: Multiple names: authors list (link)
• Erhardt A, Lucae S, Unschuld PG; et al. (2007). "Association of polymorphisms in P2RX7 and CaMKKb with anxiety disorders". Journal of affective disorders. 101 (1–3): 159–68. doi:10.1016/j.jad.2006.11.016. PMID 17197037.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)