PTPRO

Protein tyrosine phosphatase, receptor type, O
File:PBB Protein PTPRO image.jpg PDB rendering based on 2g59.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2g59​, 2gjt​, 2pi7​
Identifiers
Symbols	PTPRO ; GLEPP1; PTP-U2; PTPU2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 21564
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE PTPRO 208121 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Protein tyrosine phosphatase, receptor type, O, also known as PTPRO, is a human gene.

This gene encodes a receptor-type protein tyrosine phosphatase containing a single intracellular catalytic domain with a characteristic signature motif. The gene product, which has a transmembrane domain, is an integral membrane protein. Several alternatively spliced transcript variants, some of which encode different isoforms of the protein, have been described. These variants exhibit tissue-specific expression.

Further reading

• Thomas PE, Wharram BL, Goyal M; et al. (1994). "GLEPP1, a renal glomerular epithelial cell (podocyte) membrane protein-tyrosine phosphatase. Identification, molecular cloning, and characterization in rabbit". J. Biol. Chem. 269 (31): 19953–62. PMID 7519601.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wiggins RC, Wiggins JE, Goyal M; et al. (1995). "Molecular cloning of cDNAs encoding human GLEPP1, a membrane protein tyrosine phosphatase: characterization of the GLEPP1 protein distribution in human kidney and assignment of the GLEPP1 gene to human chromosome 12p12-p13". Genomics. 27 (1): 174–81. doi:10.1006/geno.1995.1021. PMID 7665166.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Seimiya H, Sawabe T, Inazawa J, Tsuruo T (1995). "Cloning, expression and chromosomal localization of a novel gene for protein tyrosine phosphatase (PTP-U2) induced by various differentiation-inducing agents". Oncogene. 10 (9): 1731–8. PMID 7753550.CS1 maint: Multiple names: authors list (link)
• Feito MJ, Bragardo M, Buonfiglio D; et al. (1997). "gp 120s derived from four syncytium-inducing HIV-1 strains induce different patterns of CD4 association with lymphocyte surface molecules". Int. Immunol. 9 (8): 1141–7. PMID 9263011.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Avraham S, London R, Tulloch GA; et al. (1998). "Characterization and chromosomal localization of PTPRO, a novel receptor protein tyrosine phosphatase, expressed in hematopoietic stem cells". Gene. 204 (1–2): 5–16. PMID 9434160.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Taniguchi Y, London R, Schinkmann K; et al. (1999). "The receptor protein tyrosine phosphatase, PTP-RO, is upregulated during megakaryocyte differentiation and Is associated with the c-Kit receptor". Blood. 94 (2): 539–49. PMID 10397721.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Aguiar RC, Yakushijin Y, Kharbanda S; et al. (1999). "PTPROt: an alternatively spliced and developmentally regulated B-lymphoid phosphatase that promotes G0/G1 arrest". Blood. 94 (7): 2403–13. PMID 10498613.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang Z, Bhattacharya N, Meyer MK; et al. (2001). "Pim-1 negatively regulates the activity of PTP-U2S phosphatase and influences terminal differentiation and apoptosis of monoblastoid leukemia cells". Arch. Biochem. Biophys. 390 (1): 9–18. doi:10.1006/abbi.2001.2370. PMID 11368509.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Motiwala T, Kutay H, Ghoshal K; et al. (2004). "Protein tyrosine phosphatase receptor-type O (PTPRO) exhibits characteristics of a candidate tumor suppressor in human lung cancer". Proc. Natl. Acad. Sci. U.S.A. 101 (38): 13844–9. doi:10.1073/pnas.0405451101. PMID 15356345.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen L, Juszczynski P, Takeyama K; et al. (2007). "Protein tyrosine phosphatase receptor-type O truncated (PTPROt) regulates SYK phosphorylation, proximal B-cell-receptor signaling, and cellular proliferation". Blood. 108 (10): 3428–33. doi:10.1182/blood-2006-03-013821. PMID 16888096.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Motiwala T, Majumder S, Kutay H; et al. (2007). "Methylation and silencing of protein tyrosine phosphatase receptor type O in chronic lymphocytic leukemia". Clin. Cancer Res. 13 (11): 3174–81. doi:10.1158/1078-0432.CCR-06-1720. PMID 17545520.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tian J, Wang HP, Mao YY; et al. (2007). "Reduced glomerular epithelial protein 1 expression and podocyte injury in immunoglobulin A nephropathy". J. Int. Med. Res. 35 (3): 338–45. PMID 17593862.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)