SENP1

SUMO1/sentrin specific peptidase 1
File:PBB Protein SENP1 image.jpg PDB rendering based on 2ckg.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2ckg​, 2ckh​, 2g4d​, 2iy0​, 2iy1​, 2iyc​, 2iyd​
Identifiers
Symbols	SENP1 ; SuPr-2
External IDs	Template:MGI HomoloGene: 8731
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

SUMO1/sentrin specific peptidase 1, also known as SENP1, is a human gene.

Further reading

• Cheng J, Bawa T, Lee P; et al. (2006). "Role of desumoylation in the development of prostate cancer". Neoplasia. 8 (8): 667–76. doi:10.1593/neo.06445. PMID 16925949.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gong L, Millas S, Maul GG, Yeh ET (2000). "Differential regulation of sentrinized proteins by a novel sentrin-specific protease". J. Biol. Chem. 275 (5): 3355–9. PMID 10652325.CS1 maint: Multiple names: authors list (link)
• Bailey D, O'Hare P (2003). "Herpes simplex virus 1 ICP0 co-localizes with a SUMO-specific protease". J. Gen. Virol. 83 (Pt 12): 2951–64. PMID 12466471.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bailey D, O'Hare P (2004). "Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1". J. Biol. Chem. 279 (1): 692–703. doi:10.1074/jbc.M306195200. PMID 14563852.
• Cheng J, Wang D, Wang Z, Yeh ET (2004). "SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1". Mol. Cell. Biol. 24 (13): 6021–8. doi:10.1128/MCB.24.13.6021-6028.2004. PMID 15199155.CS1 maint: Multiple names: authors list (link)
• Xu Z, Au SW (2005). "Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1". Biochem. J. 386 (Pt 2): 325–30. doi:10.1042/BJ20041210. PMID 15487983.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Boggio R, Colombo R, Hay RT; et al. (2005). "A mechanism for inhibiting the SUMO pathway". Mol. Cell. 16 (4): 549–61. doi:10.1016/j.molcel.2004.11.007. PMID 15546615.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cheng J, Perkins ND, Yeh ET (2005). "Differential regulation of c-Jun-dependent transcription by SUMO-specific proteases". J. Biol. Chem. 280 (15): 14492–8. doi:10.1074/jbc.M412185200. PMID 15701643.CS1 maint: Multiple names: authors list (link)
• Rajan S, Plant LD, Rabin ML; et al. (2005). "Sumoylation silences the plasma membrane leak K+ channel K2P1". Cell. 121 (1): 37–47. doi:10.1016/j.cell.2005.01.019. PMID 15820677.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Veltman IM, Vreede LA, Cheng J; et al. (2005). "Fusion of the SUMO/Sentrin-specific protease 1 gene SENP1 and the embryonic polarity-related mesoderm development gene MESDC2 in a patient with an infantile teratoma and a constitutional t(12;15)(q13;q25)". Hum. Mol. Genet. 14 (14): 1955–63. doi:10.1093/hmg/ddi200. PMID 15917269.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kim YH, Sung KS, Lee SJ; et al. (2005). "Desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) through the cytoplasmic-nuclear shuttling of the SUMO-specific protease SENP1". FEBS Lett. 579 (27): 6272–8. doi:10.1016/j.febslet.2005.10.010. PMID 16253240.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shen LN, Dong C, Liu H; et al. (2006). "The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing". Biochem. J. 397 (2): 279–88. doi:10.1042/BJ20052030. PMID 16553580.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xu Z, Chau SF, Lam KH; et al. (2006). "Crystal structure of the SENP1 mutant C603S-SUMO complex reveals the hydrolytic mechanism of SUMO-specific protease". Biochem. J. 398 (3): 345–52. doi:10.1042/BJ20060526. PMID 16712526.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shen L, Tatham MH, Dong C; et al. (2007). "SUMO protease SENP1 induces isomerization of the scissile peptide bond". Nat. Struct. Mol. Biol. 13 (12): 1069–77. doi:10.1038/nsmb1172. PMID 17099698.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)