BTG1

B-cell translocation gene 1, anti-proliferative
Identifiers
Symbols	BTG1 ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37521
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

B-cell translocation gene 1, anti-proliferative, also known as BTG1, is a human gene.

The BTG1 gene locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia. It is a member of a family of antiproliferative genes. BTG1 expression is maximal in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. It negatively regulates cell proliferation.

Further reading

• Rouault JP, Rimokh R, Tessa C; et al. (1992). "BTG1, a member of a new family of antiproliferative genes". EMBO J. 11 (4): 1663–70. PMID 1373383.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rimokh R, Rouault JP, Wahbi K; et al. (1991). "A chromosome 12 coding region is juxtaposed to the MYC protooncogene locus in a t(8;12)(q24;q22) translocation in a case of B-cell chronic lymphocytic leukemia". Genes Chromosomes Cancer. 3 (1): 24–36. PMID 2069907.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lin WJ, Gary JD, Yang MC; et al. (1996). "The mammalian immediate-early TIS21 protein and the leukemia-associated BTG1 protein interact with a protein-arginine N-methyltransferase". J. Biol. Chem. 271 (25): 15034–44. PMID 8663146.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Corjay MH, Kearney MA, Munzer DA; et al. (1998). "Antiproliferative gene BTG1 is highly expressed in apoptotic cells in macrophage-rich areas of advanced lesions in Watanabe heritable hyperlipidemic rabbit and human". Lab. Invest. 78 (7): 847–58. PMID 9690562.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bogdan JA, Adams-Burton C, Pedicord DL; et al. (1999). "Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1". Biochem. J. 336 ( Pt 2): 471–81. PMID 9820826.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Prévôt D, Voeltzel T, Birot AM; et al. (2000). "The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation". J. Biol. Chem. 275 (1): 147–53. PMID 10617598.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Prévôt D, Morel AP, Voeltzel T; et al. (2001). "Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway". J. Biol. Chem. 276 (13): 9640–8. doi:10.1074/jbc.M008201200. PMID 11136725.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rodier A, Rochard P, Berthet C; et al. (2001). "Identification of functional domains involved in BTG1 cell localization". Oncogene. 20 (21): 2691–703. doi:10.1038/sj.onc.1204398. PMID 11420681.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yoshida Y, Hosoda E, Nakamura T, Yamamoto T (2001). "Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex". Jpn. J. Cancer Res. 92 (6): 592–6. PMID 11429045.CS1 maint: Multiple names: authors list (link)
• Berthet C, Guéhenneux F, Revol V; et al. (2002). "Interaction of PRMT1 with BTG/TOB proteins in cell signalling: molecular analysis and functional aspects". Genes Cells. 7 (1): 29–39. PMID 11856371.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sasajima H, Nakagawa K, Yokosawa H (2002). "Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system". Eur. J. Biochem. 269 (14): 3596–604. PMID 12135500.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bakker WJ, Blázquez-Domingo M, Kolbus A; et al. (2004). "FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1". J. Cell Biol. 164 (2): 175–84. doi:10.1083/jcb.200307056. PMID 14734530.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Iwai K, Hirata K, Ishida T; et al. (2004). "An anti-proliferative gene BTG1 regulates angiogenesis in vitro". Biochem. Biophys. Res. Commun. 316 (3): 628–35. doi:10.1016/j.bbrc.2004.02.095. PMID 15033446.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Busson M, Carazo A, Seyer P; et al. (2005). "Coactivation of nuclear receptors and myogenic factors induces the major BTG1 influence on muscle differentiation". Oncogene. 24 (10): 1698–710. doi:10.1038/sj.onc.1208373. PMID 15674337.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)