DTX1
| Deltex homolog 1 (Drosophila) | |||||||||||
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| Symbols | DTX1 ; hDx-1 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 74522 | ||||||||||
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| Species | Human | Mouse | |||||||||
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| RefSeq (protein) | n/a | n/a | |||||||||
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Deltex homolog 1 (Drosophila), also known as DTX1, is a human gene.[1]
Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity.[1]
References
Further reading
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Saito T, Chiba S, Ichikawa M; et al. (2003). "Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development". Immunity. 18 (5): 675–85. PMID 12753744.
- Takeyama K, Aguiar RC, Gu L; et al. (2003). "The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity". J. Biol. Chem. 278 (24): 21930–7. doi:10.1074/jbc.M301157200. PMID 12670957.
- Gupta-Rossi N, Storck S, Griebel PJ; et al. (2003). "Specific over-expression of deltex and a new Kelch-like protein in human germinal center B cells". Mol. Immunol. 39 (13): 791–9. PMID 12617994.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Izon DJ, Aster JC, He Y; et al. (2002). "Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1". Immunity. 16 (2): 231–43. PMID 11869684.
- Yamamoto N, Yamamoto S, Inagaki F; et al. (2002). "Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor". J. Biol. Chem. 276 (48): 45031–40. doi:10.1074/jbc.M105245200. PMID 11564735.
- Kishi N, Tang Z, Maeda Y; et al. (2001). "Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis". Int. J. Dev. Neurosci. 19 (1): 21–35. PMID 11226752.
- Lee L, Dowhanick-Morrissette J, Katz A; et al. (2001). "Chromosomal localization, genomic characterization, and mapping to the Noonan syndrome critical region of the human Deltex (DTX1) gene". Hum. Genet. 107 (6): 577–81. PMID 11153911.
- Matsuno K, Eastman D, Mitsiades T; et al. (1998). "Human deltex is a conserved regulator of Notch signalling". Nat. Genet. 19 (1): 74–8. doi:10.1038/ng0598-74. PMID 9590294.
- Blaumueller CM, Qi H, Zagouras P, Artavanis-Tsakonas S (1997). "Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane". Cell. 90 (2): 281–91. PMID 9244302.
- Matsuno K, Diederich RJ, Go MJ; et al. (1995). "Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats". Development. 121 (8): 2633–44. PMID 7671825.
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