KIF5A

Kinesin family member 5A
File:PBB Protein KIF5A image.jpg PDB rendering based on 2kin.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2kin​, 3kin​
Identifiers
Symbols	KIF5A ; D12S1889; MY050; NKHC; SPG10
External IDs	Template:OMIM5 Template:MGI HomoloGene: 55861
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE KIF5A 205318 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Kinesin family member 5A, also known as KIF5A, is a human gene.

This gene encodes a member of the kinesin family of proteins. Members of this family are part of a multisubunit complex that functions as a microtubule motor in intracellular organelle transport. Mutations in this gene cause autosomal dominant spastic paraplegia 10.

Further reading

• Fichera M, Lo Giudice M, Falco M; et al. (2005). "Evidence of kinesin heavy chain (KIF5A) involvement in pure hereditary spastic paraplegia". Neurology. 63 (6): 1108–10. PMID 15452312.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Niclas J, Navone F, Hom-Booher N, Vale RD (1994). "Cloning and localization of a conventional kinesin motor expressed exclusively in neurons". Neuron. 12 (5): 1059–72. PMID 7514426.CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Rahman A, Friedman DS, Goldstein LS (1998). "Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins". J. Biol. Chem. 273 (25): 15395–403. PMID 9624122.CS1 maint: Multiple names: authors list (link)
• Hamlin PJ, Jones PF, Leek JP; et al. (1999). "Assignment of GALGT encoding beta-1, 4N-acetylgalactosaminyl-transferase (GalNAc-T) and KIF5A encoding neuronal kinesin (D12S1889) to human chromosome band 12q13 by assignment to ICI YAC 26EG10 and in situ hybridization. medjph@stjames.leeds.ac.uk". Cytogenet. Cell Genet. 82 (3–4): 267–8. PMID 9858832.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Reid E, Dearlove AM, Rhodes M, Rubinsztein DC (1999). "A new locus for autosomal dominant "pure" hereditary spastic paraplegia mapping to chromosome 12q13, and evidence for further genetic heterogeneity". Am. J. Hum. Genet. 65 (3): 757–63. PMID 10441583.CS1 maint: Multiple names: authors list (link)
• Rahman A, Kamal A, Roberts EA, Goldstein LS (1999). "Defective kinesin heavy chain behavior in mouse kinesin light chain mutants". J. Cell Biol. 146 (6): 1277–88. PMID 10491391.CS1 maint: Multiple names: authors list (link)
• Kanai Y, Okada Y, Tanaka Y; et al. (2000). "KIF5C, a novel neuronal kinesin enriched in motor neurons". J. Neurosci. 20 (17): 6374–84. PMID 10964943.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Setou M, Seog DH, Tanaka Y; et al. (2002). "Glutamate-receptor-interacting protein GRIP1 directly steers kinesin to dendrites". Nature. 417 (6884): 83–7. doi:10.1038/nature743. PMID 11986669.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Reid E, Kloos M, Ashley-Koch A; et al. (2003). "A kinesin heavy chain (KIF5A) mutation in hereditary spastic paraplegia (SPG10)". Am. J. Hum. Genet. 71 (5): 1189–94. PMID 12355402.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Macioce P, Gambara G, Bernassola M; et al. (2004). "Beta-dystrobrevin interacts directly with kinesin heavy chain in brain". J. Cell. Sci. 116 (Pt 23): 4847–56. doi:10.1242/jcs.00805. PMID 14600269.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Amit I, Yakir L, Katz M; et al. (2004). "Tal, a Tsg101-specific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus budding". Genes Dev. 18 (14): 1737–52. doi:10.1101/gad.294904. PMID 15256501.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stelzl U, Worm U, Lalowski M; et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Blair MA, Ma S, Hedera P (2007). "Mutation in KIF5A can also cause adult-onset hereditary spastic paraplegia". Neurogenetics. 7 (1): 47–50. doi:10.1007/s10048-005-0027-8. PMID 16489470.CS1 maint: Multiple names: authors list (link)