RAP2A

RAP2A, member of RAS oncogene family
File:PBB Protein RAP2A image.jpg PDB rendering based on 1kao.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1kao​, 2rap​, 3rap​
Identifiers
Symbols	RAP2A ; K-REV; KREV; RAP2; RbBP-30
External IDs	Template:OMIM5 Template:MGI HomoloGene: 10875
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE RAP2A 214487 s at tn.png
File:PBB GE RAP2A 221830 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

RAP2A, member of RAS oncogene family, also known as RAP2A, is a human gene.

Further reading

• Lerosey I, Chardin P, de Gunzburg J, Tavitian A (1991). "The product of the rap2 gene, member of the ras superfamily. Biochemical characterization and site-directed mutagenesis". J. Biol. Chem. 266 (7): 4315–21. PMID 1900290.CS1 maint: Multiple names: authors list (link)
• Pizon V, Chardin P, Lerosey I; et al. (1988). "Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region". Oncogene. 3 (2): 201–4. PMID 3045729.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Farrell FX, Yamamoto K, Lapetina EG (1993). "Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated". Biochem. J. 289 ( Pt 2): 349–55. PMID 8424780.CS1 maint: Multiple names: authors list (link)
• Cherfils J, Ménétrey J, Le Bras G; et al. (1997). "Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTPgammaS". EMBO J. 16 (18): 5582–91. doi:10.1093/emboj/16.18.5582. PMID 9312017.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Janoueix-Lerosey I, Pasheva E, de Tand MF; et al. (1998). "Identification of a specific effector of the small GTP-binding protein Rap2". Eur. J. Biochem. 252 (2): 290–8. PMID 9523700.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nancy V, Wolthuis RM, de Tand MF; et al. (1999). "Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2". J. Biol. Chem. 274 (13): 8737–45. PMID 10085114.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Linnemann T, Geyer M, Jaitner BK; et al. (1999). "Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily". J. Biol. Chem. 274 (19): 13556–62. PMID 10224125.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ménétrey J, Cherfils J (2000). "Structure of the small G protein Rap2 in a non-catalytic complex with GTP". Proteins. 37 (3): 465–73. PMID 10591105.
• de Rooij J, Rehmann H, van Triest M; et al. (2000). "Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs". J. Biol. Chem. 275 (27): 20829–36. doi:10.1074/jbc.M001113200. PMID 10777494.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Husi H, Ward MA, Choudhary JS; et al. (2000). "Proteomic analysis of NMDA receptor-adhesion protein signaling complexes". Nat. Neurosci. 3 (7): 661–9. doi:10.1038/76615. PMID 10862698.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Traver S, Bidot C, Spassky N; et al. (2001). "RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao". Biochem. J. 350 Pt 1: 19–29. PMID 10926822.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gao X, Satoh T, Liao Y; et al. (2001). "Identification and characterization of RA-GEF-2, a Rap guanine nucleotide exchange factor that serves as a downstream target of M-Ras". J. Biol. Chem. 276 (45): 42219–25. doi:10.1074/jbc.M105760200. PMID 11524421.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ortiz-Vega S, Khokhlatchev A, Nedwidek M; et al. (2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene. 21 (9): 1381–90. doi:10.1038/sj.onc.1205192. PMID 11857081.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Song C, Satoh T, Edamatsu H; et al. (2002). "Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon". Oncogene. 21 (53): 8105–13. doi:10.1038/sj.onc.1206003. PMID 12444546.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kuiperij HB, de Rooij J, Rehmann H; et al. (2003). "Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2". Biochim. Biophys. Acta. 1593 (2–3): 141–9. PMID 12581858.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Machida N, Umikawa M, Takei K; et al. (2004). "Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase". J. Biol. Chem. 279 (16): 15711–4. doi:10.1074/jbc.C300542200. PMID 14966141.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mitin NY, Ramocki MB, Zullo AJ; et al. (2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". J. Biol. Chem. 279 (21): 22353–61. doi:10.1074/jbc.M312867200. PMID 15031288.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dunham A, Matthews LH, Burton J; et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. doi:10.1038/nature02379. PMID 15057823.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)