KTN1

Kinectin 1 (kinesin receptor)
Identifiers
Symbols	KTN1 ; CG1; KIAA0004; KNT; MGC133337; MU-RMS-40.19
External IDs	Template:OMIM5 Template:MGI HomoloGene: 7397
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE KTN1 214709 s at tn.png
File:PBB GE KTN1 200914 x at tn.png
File:PBB GE KTN1 200915 x at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Kinectin 1 (kinesin receptor), also known as KTN1, is a human gene.

Various cellular organelles and vesicles are transported along the microtubules in the cytoplasm. Likewise, membrane recycling of the endoplasmic reticulum (ER), Golgi assembly at the microtubule organizing center, and alignment of lysosomes along microtubules are all related processes. The transport of organelles requires a special class of microtubule-associated proteins (MAPs). One of these is the molecular motor kinesin (see MIM 148760 and MIM 600025), an ATPase that moves vesicles unidirectionally toward the plus end of the microtubule. Another such MAP is kinectin, a large integral ER membrane protein. Antibodies directed against kinectin have been shown to inhibit its binding to kinesin.[supplied by OMIM]

Further reading

• Nomura N, Miyajima N, Sazuka T; et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. PMID 7584026.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nomura N, Miyajima N, Sazuka T; et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. PMID 7584028.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fütterer A, Kruppa G, Krämer B; et al. (1995). "Molecular cloning and characterization of human kinectin". Mol. Biol. Cell. 6 (2): 161–70. PMID 7787243.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yu H, Nicchitta CV, Kumar J; et al. (1995). "Characterization of kinectin, a kinesin-binding protein: primary sequence and N-terminal topogenic signal analysis". Mol. Biol. Cell. 6 (2): 171–83. PMID 7787244.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Print CG, Leung E, Harrison JE; et al. (1994). "Cloning of a gene encoding a human leukocyte protein characterised by extensive heptad repeats". Gene. 144 (2): 221–8. PMID 8039706.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Print CG, Morris CM, Spurr NK; et al. (1996). "The CG-1 gene, a member of the kinectin and ES/130 family, maps to human chromosome band 14q22". Immunogenetics. 43 (4): 227–9. PMID 8575822.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hotta K, Tanaka K, Mino A; et al. (1996). "Interaction of the Rho family small G proteins with kinectin, an anchoring protein of kinesin motor". Biochem. Biophys. Res. Commun. 225 (1): 69–74. doi:10.1006/bbrc.1996.1132. PMID 8769096.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Alberts AS, Bouquin N, Johnston LH, Treisman R (1998). "Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7". J. Biol. Chem. 273 (15): 8616–22. PMID 9535835.CS1 maint: Multiple names: authors list (link)
• Rao PN, Yu H, Hodge R; et al. (1998). "Assignment of the human kinectin gene (KTN1), encoding a kinesin-binding protein, to chromosome 14 band q22.1 by in situ hybridization". Cytogenet. Cell Genet. 79 (3–4): 196–7. PMID 9605849.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vancoillie G, Lambert J, Mulder A; et al. (2000). "Kinesin and kinectin can associate with the melanosomal surface and form a link with microtubules in normal human melanocytes". J. Invest. Dermatol. 114 (3): 421–9. doi:10.1046/j.1523-1747.2000.00896.x. PMID 10692099.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Salassidis K, Bruch J, Zitzelsberger H; et al. (2000). "Translocation t(10;14)(q11.2:q22.1) fusing the kinetin to the RET gene creates a novel rearranged form (PTC8) of the RET proto-oncogene in radiation-induced childhood papillary thyroid carcinoma". Cancer Res. 60 (11): 2786–9. PMID 10850414.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ong LL, Lim AP, Er CP; et al. (2000). "Kinectin-kinesin binding domains and their effects on organelle motility". J. Biol. Chem. 275 (42): 32854–60. doi:10.1074/jbc.M005650200. PMID 10913441.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Harrington JJ, Sherf B, Rundlett S; et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vignal E, Blangy A, Martin M; et al. (2001). "Kinectin is a key effector of RhoG microtubule-dependent cellular activity". Mol. Cell. Biol. 21 (23): 8022–34. doi:10.1128/MCB.21.23.8022-8034.2001. PMID 11689693.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tran H, Pankov R, Tran SD; et al. (2003). "Integrin clustering induces kinectin accumulation". J. Cell. Sci. 115 (Pt 10): 2031–40. PMID 11973345.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Heilig R, Eckenberg R, Petit JL; et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ong LL, Er CP, Ho A; et al. (2003). "Kinectin anchors the translation elongation factor-1 delta to the endoplasmic reticulum". J. Biol. Chem. 278 (34): 32115–23. doi:10.1074/jbc.M210917200. PMID 12773547.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bouwmeester T, Bauch A, Ruffner H; et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)