SNW1
| SNW domain containing 1 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | SNW1 ; Bx42; MGC119379; NCOA-62; PRPF45; Prp45; SKIIP; SKIP | ||||||||||
| External IDs | Template:OMIM5 HomoloGene: 56557 | ||||||||||
| |||||||||||
| RNA expression pattern | |||||||||||
| File:PBB GE SNW1 201575 at tn.png | |||||||||||
| File:PBB GE SNW1 215424 s at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
SNW domain containing 1, also known as SNW1, is a human gene.[1]
This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity.[1]
References
Further reading
- Folk P, Půta F, Krpejsová L; et al. (1997). "The homolog of chromatin binding protein Bx42 identified in Dictyostelium". Gene. 181 (1–2): 229–31. PMID 8973337.
- Dahl R, Wani B, Hayman MJ (1998). "The Ski oncoprotein interacts with Skip, the human homolog of Drosophila Bx42". Oncogene. 16 (12): 1579–86. doi:10.1038/sj.onc.1201687. PMID 9569025.
- Baudino TA, Kraichely DM, Jefcoat SC; et al. (1998). "Isolation and characterization of a novel coactivator protein, NCoA-62, involved in vitamin D-mediated transcription". J. Biol. Chem. 273 (26): 16434–41. PMID 9632709.
- Zhou S, Fujimuro M, Hsieh JJ; et al. (2000). "A role for SKIP in EBNA2 activation of CBF1-repressed promoters". J. Virol. 74 (4): 1939–47. PMID 10644367.
- Zhou S, Fujimuro M, Hsieh JJ; et al. (2000). "SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function". Mol. Cell. Biol. 20 (7): 2400–10. PMID 10713164.
- Leong GM, Subramaniam N, Figueroa J; et al. (2001). "Ski-interacting protein interacts with Smad proteins to augment transforming growth factor-beta-dependent transcription". J. Biol. Chem. 276 (21): 18243–8. doi:10.1074/jbc.M010815200. PMID 11278756.
- Kim YJ, Noguchi S, Hayashi YK; et al. (2001). "The product of an oculopharyngeal muscular dystrophy gene, poly(A)-binding protein 2, interacts with SKIP and stimulates muscle-specific gene expression". Hum. Mol. Genet. 10 (11): 1129–39. PMID 11371506.
- Beatus P, Lundkvist J, Oberg C; et al. (2001). "The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity". Mech. Dev. 104 (1–2): 3–20. PMID 11404076.
- Zhou S, Hayward SD (2001). "Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex". Mol. Cell. Biol. 21 (18): 6222–32. PMID 11509665.
- Zhang C, Baudino TA, Dowd DR; et al. (2001). "Ternary complexes and cooperative interplay between NCoA-62/Ski-interacting protein and steroid receptor coactivators in vitamin D receptor-mediated transcription". J. Biol. Chem. 276 (44): 40614–20. doi:10.1074/jbc.M106263200. PMID 11514567.
- Prathapam T, Kühne C, Hayman M, Banks L (2001). "Ski interacts with the evolutionarily conserved SNW domain of Skip". Nucleic Acids Res. 29 (17): 3469–76. PMID 11522815.
- Jurica MS, Licklider LJ, Gygi SR; et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. PMID 11991638.
- Wardell SE, Boonyaratanakornkit V, Adelman JS; et al. (2002). "Jun dimerization protein 2 functions as a progesterone receptor N-terminal domain coactivator". Mol. Cell. Biol. 22 (15): 5451–66. PMID 12101239.
- Prathapam T, Kühne C, Banks L (2002). "Skip interacts with the retinoblastoma tumor suppressor and inhibits its transcriptional repression activity". Nucleic Acids Res. 30 (23): 5261–8. PMID 12466551.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Petersen HH, Hilpert J, Militz D; et al. (2003). "Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule". J. Cell. Sci. 116 (Pt 3): 453–61. PMID 12508107.
- Heilig R, Eckenberg R, Petit JL; et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121.
- Barry JB, Leong GM, Church WB; et al. (2003). "Interactions of SKIP/NCoA-62, TFIIB, and retinoid X receptor with vitamin D receptor helix H10 residues". J. Biol. Chem. 278 (10): 8224–8. doi:10.1074/jbc.C200712200. PMID 12529369.
- Zhang C, Dowd DR, Staal A; et al. (2003). "Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicing". J. Biol. Chem. 278 (37): 35325–36. doi:10.1074/jbc.M305191200. PMID 12840015.
- Leong GM, Subramaniam N, Issa LL; et al. (2004). "Ski-interacting protein, a bifunctional nuclear receptor coregulator that interacts with N-CoR/SMRT and p300". Biochem. Biophys. Res. Commun. 315 (4): 1070–6. doi:10.1016/j.bbrc.2004.02.004. PMID 14985122.
 | This protein-related article is a stub. You can help Wikipedia by expanding it. |