AKT1

V-akt murine thymoma viral oncogene homolog 1, also known as AKT1, is a human gene.

V-akt murine thymoma viral oncogene homolog 1
PDB rendering based on 1h10.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1h10​, 1unp​, 1unq​, 1unr​, 2uvm​
Identifiers
Symbols	AKT1 ; AKT; MGC99656; PKB; PRKBA; RAC; RAC-ALPHA
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3785
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE AKT1 207163 s at.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene.

Further reading

• Hemmings BA (1997). "Akt signaling: linking membrane events to life and death decisions". Science. 275 (5300): 628–30. PMID 9019819.
• Vanhaesebroeck B, Alessi DR (2000). "The PI3K-PDK1 connection: more than just a road to PKB". Biochem. J. 346 Pt 3: 561–76. PMID 10698680.
• Chan TO, Rittenhouse SE, Tsichlis PN (2000). "AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation". Annu. Rev. Biochem. 68: 965–1014. doi:10.1146/annurev.biochem.68.1.965. PMID 10872470.CS1 maint: Multiple names: authors list (link)
• Pekarsky Y, Hallas C, Croce CM (2001). "Molecular basis of mature T-cell leukemia". JAMA. 286 (18): 2308–14. PMID 11710897.CS1 maint: Multiple names: authors list (link)
• Dickson LM, Rhodes CJ (2004). "Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt?". Am. J. Physiol. Endocrinol. Metab. 287 (2): E192–8. doi:10.1152/ajpendo.00031.2004. PMID 15271644.
• Manning BD (2004). "Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis". J. Cell Biol. 167 (3): 399–403. doi:10.1083/jcb.200408161. PMID 15533996.
• Shinohara M, Chung YJ, Saji M, Ringel MD (2007). "AKT in thyroid tumorigenesis and progression". Endocrinology. 148 (3): 942–7. doi:10.1210/en.2006-0937. PMID 16946008.CS1 maint: Multiple names: authors list (link)