TCF12
| Transcription factor 12 (HTF4, helix-loop-helix transcription factors 4) | |||||||||||
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| Identifiers | |||||||||||
| Symbols | TCF12 ; HEB; HTF4; HsT17266 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 40774 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE TCF12 208986 at tn.png | |||||||||||
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| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
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Transcription factor 12 (HTF4, helix-loop-helix transcription factors 4), also known as TCF12, is a human gene.[1]
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[1]
References
Further reading
- Bain G, Murre C (1998). "The role of E-proteins in B- and T-lymphocyte development". Semin. Immunol. 10 (2): 143–53. doi:10.1006/smim.1998.0116. PMID 9618760.
- Hu JS, Olson EN, Kingston RE (1992). "HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors". Mol. Cell. Biol. 12 (3): 1031–42. PMID 1312219.
- Zhang Y, Bina M (1992). "The nucleotide sequence of the human transcription factor HTF4a cDNA". DNA Seq. 2 (6): 397–403. PMID 1446075.
- Zhang Y, Doyle K, Bina M (1992). "Interactions of HTF4 with E-box motifs in the long terminal repeat of human immunodeficiency virus type 1". J. Virol. 66 (9): 5631–4. PMID 1501295.
- Sommer L, Hagenbüchle O, Wellauer PK, Strubin M (1992). "Nuclear targeting of the transcription factor PTF1 is mediated by a protein subunit that does not bind to the PTF1 cognate sequence". Cell. 67 (5): 987–94. PMID 1720355.
- Zhang Y, Babin J, Feldhaus AL; et al. (1991). "HTF4: a new human helix-loop-helix protein". Nucleic Acids Res. 19 (16): 4555. PMID 1886779.
- Zhang Y, Flejter WL, Barcroft CL; et al. (1995). "Localization of the human HTF4 transcription factors 4 gene (TCF12) to chromosome 15q21". Cytogenet. Cell Genet. 68 (3–4): 235–8. PMID 7842744.
- Doyle K, Zhang Y, Baer R, Bina M (1994). "Distinguishable patterns of protein-DNA interactions involving complexes of basic helix-loop-helix proteins". J. Biol. Chem. 269 (16): 12099–105. PMID 8163514.
- Langlands K, Yin X, Anand G, Prochownik EV (1997). "Differential interactions of Id proteins with basic-helix-loop-helix transcription factors". J. Biol. Chem. 272 (32): 19785–93. PMID 9242638.
- Goldfarb AN, Lewandowska K, Pennell CA (1998). "Identification of a highly conserved module in E proteins required for in vivo helix-loop-helix dimerization". J. Biol. Chem. 273 (5): 2866–73. PMID 9446597.
- Massari ME, Rivera RR, Voland JR; et al. (1998). "Characterization of ABF-1, a novel basic helix-loop-helix transcription factor expressed in activated B lymphocytes". Mol. Cell. Biol. 18 (6): 3130–9. PMID 9584154.
- Adell T, Gómez-Cuadrado A, Skoudy A; et al. (2000). "Role of the basic helix-loop-helix transcription factor p48 in the differentiation phenotype of exocrine pancreas cancer cells". Cell Growth Differ. 11 (3): 137–47. PMID 10768861.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.
- Wiemann S, Weil B, Wellenreuther R; et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
- Simpson JC, Wellenreuther R, Poustka A; et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
- Mandolesi G, Gargano S, Pennuto M; et al. (2002). "NGF-dependent and tissue-specific transcription of vgf is regulated by a CREB-p300 and bHLH factor interaction". FEBS Lett. 510 (1–2): 50–6. PMID 11755530.
- Knöfler M, Meinhardt G, Bauer S; et al. (2002). "Human Hand1 basic helix-loop-helix (bHLH) protein: extra-embryonic expression pattern, interaction partners and identification of its transcriptional repressor domains". Biochem. J. 361 (Pt 3): 641–51. PMID 11802795.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Tremblay M, Herblot S, Lecuyer E, Hoang T (2003). "Regulation of pT alpha gene expression by a dosage of E2A, HEB, and SCL". J. Biol. Chem. 278 (15): 12680–7. doi:10.1074/jbc.M209870200. PMID 12566462.
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