ACTC1

Actin, alpha, cardiac muscle 1
File:PBB Protein ACTC1 image.jpg PDB rendering based on 1atn.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1atn​, 1c0g​, 1d4x​, 1dej​, 1eqy​, 1esv​, 1h1v​, 1hlu​, 1ijj​, 1j6z​, 1kxp​, 1lcu​, 1lot​, 1m8q​, 1ma9​, 1mdu​, 1mvw​, 1nlv​, 1nm1​, 1nmd​, 1nwk​, 1o18​, 1o19​, 1o1a​, 1o1b​, 1o1c​, 1o1d​, 1o1e​, 1o1f​, 1o1g​, 1p8z​, 1qz5​, 1qz6​, 1rdw​, 1rfq​, 1rgi​, 1s22​, 1sqk​, 1t44​, 1wua​, 1y64​, 1yxq​, 2a3z​, 2a40​, 2a41​, 2a42​, 2a5x​, 2asm​, 2aso​, 2asp​, 2btf​, 2d1k​, 2ff3​, 2ff6​, 2fxu​, 2gwj​, 2gwk​, 2hf3​, 2hf4​, 2hmp​, 2oan​, 2q1n​, 2q31​, 2q36​
Identifiers
Symbols	ACTC1 ; ACTC; CMD1R
External IDs	Template:OMIM5 Template:MGI HomoloGene: 68446
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Actin, alpha, cardiac muscle 1, also known as ACTC1, is a human gene.

Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC).

Further reading

• Snásel J, Pichová I (1997). "The cleavage of host cell proteins by HIV-1 protease". Folia Biol. (Praha). 42 (5): 227–30. PMID 8997639.
• Bearer EL, Prakash JM, Li Z (2002). "Actin dynamics in platelets". Int. Rev. Cytol. 217: 137–82. PMID 12019562.CS1 maint: Multiple names: authors list (link)
• Elzinga M, Maron BJ, Adelstein RS (1976). "Human heart and platelet actins are products of different genes". Science. 191 (4222): 94–5. PMID 1246600.CS1 maint: Multiple names: authors list (link)
• Adams LD, Tomasselli AG, Robbins P; et al. (1992). "HIV-1 protease cleaves actin during acute infection of human T-lymphocytes". AIDS Res. Hum. Retroviruses. 8 (2): 291–5. PMID 1540415.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. PMID 1602151.
• Kramer PL, Luty JA, Litt M (1992). "Regional localization of the gene for cardiac muscle actin (ACTC) on chromosome 15q". Genomics. 13 (3): 904–5. PMID 1639426.CS1 maint: Multiple names: authors list (link)
• Watkins C, Bodfish P, Warne D; et al. (1992). "Dinucleotide repeat polymorphism in the human alpha-cardiac actin gene, intron IV (ACTC), detected using the polymerase chain reaction". Nucleic Acids Res. 19 (24): 6980. PMID 1762945.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tomasselli AG, Hui JO, Adams L; et al. (1991). "Actin, troponin C, Alzheimer amyloid precursor protein and pro-interleukin 1 beta as substrates of the protease from human immunodeficiency virus". J. Biol. Chem. 266 (22): 14548–53. PMID 1907279.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shoeman RL, Kesselmier C, Mothes E; et al. (1991). "Non-viral cellular substrates for human immunodeficiency virus type 1 protease". FEBS Lett. 278 (2): 199–203. PMID 1991513.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Buckingham M, Alonso S, Barton P; et al. (1987). "Actin and myosin multigene families: their expression during the formation and maturation of striated muscle". Am. J. Med. Genet. 25 (4): 623–34. doi:10.1002/ajmg.1320250405. PMID 3789022.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Engel JN, Gunning PW, Kedes L (1982). "Isolation and characterization of human actin genes". Proc. Natl. Acad. Sci. U.S.A. 78 (8): 4674–8. PMID 6272269.CS1 maint: Multiple names: authors list (link)
• Humphries SE, Whittall R, Minty A; et al. (1982). "There are approximately 20 actin gene in the human genome". Nucleic Acids Res. 9 (19): 4895–908. PMID 6273789.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hamada H, Petrino MG, Kakunaga T (1983). "Molecular structure and evolutionary origin of human cardiac muscle actin gene". Proc. Natl. Acad. Sci. U.S.A. 79 (19): 5901–5. PMID 6310553.CS1 maint: Multiple names: authors list (link)
• Gunning P, Ponte P, Kedes L; et al. (1984). "Chromosomal location of the co-expressed human skeletal and cardiac actin genes". Proc. Natl. Acad. Sci. U.S.A. 81 (6): 1813–7. PMID 6584914.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gunning P, Ponte P, Blau H, Kedes L (1984). "alpha-skeletal and alpha-cardiac actin genes are coexpressed in adult human skeletal muscle and heart". Mol. Cell. Biol. 3 (11): 1985–95. PMID 6689196.CS1 maint: Multiple names: authors list (link)
• Ueyama H, Inazawa J, Ariyama T; et al. (1995). "Reexamination of chromosomal loci of human muscle actin genes by fluorescence in situ hybridization". Jpn. J. Hum. Genet. 40 (1): 145–8. PMID 7780165.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Moroianu J, Riordan JF (1994). "Nuclear translocation of angiogenin in proliferating endothelial cells is essential to its angiogenic activity". Proc. Natl. Acad. Sci. U.S.A. 91 (5): 1677–81. PMID 8127865.
• Dunwoodie SL, Joya JE, Arkell RM, Hardeman EC (1994). "Multiple regions of the human cardiac actin gene are necessary for maturation-based expression in striated muscle". J. Biol. Chem. 269 (16): 12212–9. PMID 8163527.CS1 maint: Multiple names: authors list (link)
• Shuster CB, Lin AY, Nayak R, Herman IM (1997). "Beta cap73: a novel beta actin-specific binding protein". Cell Motil. Cytoskeleton. 35 (3): 175–87. doi:10.1002/(SICI)1097-0169(1996)35:3<175::AID-CM1>3.0.CO;2-8. PMID 8913639.CS1 maint: Multiple names: authors list (link)