Feline sarcoma oncogene
Feline sarcoma oncogene | |||||||||||||
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PDB rendering based on 1wqu. | |||||||||||||
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Identifiers | |||||||||||||
Symbols | FES ; FPS | ||||||||||||
External IDs | Template:OMIM5 Template:MGI HomoloGene: 37563 | ||||||||||||
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RNA expression pattern | |||||||||||||
More reference expression data | |||||||||||||
Orthologs | |||||||||||||
Template:GNF Ortholog box | |||||||||||||
Species | Human | Mouse | |||||||||||
Entrez | n/a | n/a | |||||||||||
Ensembl | n/a | n/a | |||||||||||
UniProt | n/a | n/a | |||||||||||
RefSeq (mRNA) | n/a | n/a | |||||||||||
RefSeq (protein) | n/a | n/a | |||||||||||
Location (UCSC) | n/a | n/a | |||||||||||
PubMed search | n/a | n/a |
Feline sarcoma oncogene, also known as FES, is a human gene.[1]
This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis. A truncated transcript has been identified that is generated utilizing a start site in one of the far downstream exons but a protein product associated with this transcript has not been identified.[1]
References
Further reading
- Smithgall TE, Rogers JA, Peters KL; et al. (1998). "The c-Fes family of protein-tyrosine kinases". Critical reviews in oncogenesis. 9 (1): 43–62. PMID 9754447.
- Jiang H, Harris MB, Rothman P (2000). "IL-4/IL-13 signaling beyond JAK/STAT". J. Allergy Clin. Immunol. 105 (6 Pt 1): 1063–70. PMID 10856136.
- Greer P (2002). "Closing in on the biological functions of Fps/Fes and Fer". Nat. Rev. Mol. Cell Biol. 3 (4): 278–89. doi:10.1038/nrm783. PMID 11994747.
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