PCSK6
| Proprotein convertase subtilisin/kexin type 6 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | PCSK6 ; PACE4; SPC4 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 20569 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE PCSK6 207414 s at tn.png | |||||||||||
| File:PBB GE PCSK6 211263 s at tn.png | |||||||||||
| File:PBB GE PCSK6 211262 at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Proprotein convertase subtilisin/kexin type 6, also known as PCSK6, is a human gene.[1]
The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can cleave precursor protein at their paired basic amino acid processing sites. Some of its substrates are - transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression. Alternatively spliced transcript variants encoding different isoforms have been identified.[1]
References
Further reading
- Bassi DE, Mahloogi H, Klein-Szanto AJ (2000). "The proprotein convertases furin and PACE4 play a significant role in tumor progression". Mol. Carcinog. 28 (2): 63–9. PMID 10900462.
- Moulard M, Decroly E (2001). "Maturation of HIV envelope glycoprotein precursors by cellular endoproteases". Biochim. Biophys. Acta. 1469 (3): 121–32. PMID 11063880.
- Seidah NG, Prat A (2003). "Precursor convertases in the secretory pathway, cytosol and extracellular milieu". Essays Biochem. 38: 79–94. PMID 12463163.
- Kiefer MC, Tucker JE, Joh R; et al. (1992). "Identification of a second human subtilisin-like protease gene in the fes/fps region of chromosome 15". DNA Cell Biol. 10 (10): 757–69. PMID 1741956.
- Tsuji A, Higashine K, Hine C; et al. (1994). ""Identification of novel cDNAs encoding human kexin-like protease, PACE4 isoforms."". Biochem. Biophys. Res. Commun. 204 (3): 1381–2. PMID 7980617.
- Tsuji A, Higashine K, Hine C; et al. (1994). "Identification of novel cDNAs encoding human kexin-like protease, PACE4 isoforms". Biochem. Biophys. Res. Commun. 200 (2): 943–50. doi:10.1006/bbrc.1994.1541. PMID 8179631.
- Vollenweider F, Benjannet S, Decroly E; et al. (1996). "Comparative cellular processing of the human immunodeficiency virus (HIV-1) envelope glycoprotein gp160 by the mammalian subtilisin/kexin-like convertases". Biochem. J. 314 ( Pt 2): 521–32. PMID 8670066.
- Zhong M, Benjannet S, Lazure C; et al. (1997). "Functional analysis of human PACE4-A and PACE4-C isoforms: identification of a new PACE4-CS isoform". FEBS Lett. 396 (1): 31–6. PMID 8906861.
- Decroly E, Wouters S, Di Bello C; et al. (1997). "Identification of the paired basic convertases implicated in HIV gp160 processing based on in vitro assays and expression in CD4(+) cell lines". J. Biol. Chem. 271 (48): 30442–50. PMID 8940009.
- Inocencio NM, Sucic JF, Moehring JM; et al. (1997). "Endoprotease activities other than furin and PACE4 with a role in processing of HIV-I gp160 glycoproteins in CHO-K1 cells". J. Biol. Chem. 272 (2): 1344–8. PMID 8995442.
- Mori K, Kii S, Tsuji A; et al. (1997). "A novel human PACE4 isoform, PACE4E is an active processing protease containing a hydrophobic cluster at the carboxy terminus". J. Biochem. 121 (5): 941–8. PMID 9192737.
- Tsuji A, Hine C, Tamai Y; et al. (1997). "Genomic organization and alternative splicing of human PACE4 (SPC4), kexin-like processing endoprotease". J. Biochem. 122 (2): 438–52. PMID 9378725.
- Moulard M, Chaloin L, Canarelli S; et al. (1998). "Retroviral envelope glycoprotein processing: structural investigation of the cleavage site". Biochemistry. 37 (13): 4510–7. doi:10.1021/bi972662f. PMID 9521771.
- Nagahama M, Taniguchi T, Hashimoto E; et al. (1998). "Biosynthetic processing and quaternary interactions of proprotein convertase SPC4 (PACE4)". FEBS Lett. 434 (1–2): 155–9. PMID 9738469.
- Viale A, Ortola C, Hervieu G; et al. (1999). "Cellular localization and role of prohormone convertases in the processing of pro-melanin concentrating hormone in mammals". J. Biol. Chem. 274 (10): 6536–45. PMID 10037747.
- Mori K, Imamaki A, Nagata K; et al. (1999). "Subtilisin-like proprotein convertases, PACE4 and PC8, as well as furin, are endogenous proalbumin convertases in HepG2 cells". J. Biochem. 125 (3): 627–33. PMID 10050053.
- Sucic JF, Moehring JM, Inocencio NM; et al. (1999). "Endoprotease PACE4 is Ca2+-dependent and temperature-sensitive and can partly rescue the phenotype of a furin-deficient cell strain". Biochem. J. 339 ( Pt 3): 639–47. PMID 10215603.
- Tsuji A, Yoshida S, Hasegawa S; et al. (2000). "Human subtilisin-like proprotein convertase, PACE4 (SPC4) gene expression is highly regulated through E-box elements in HepG2 and GH4C1 cells". J. Biochem. 126 (3): 494–502. PMID 10467164.
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