PRC1
| Protein regulator of cytokinesis 1 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | PRC1 ; ASE1; MGC1671; MGC3669 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 37868 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE PRC1 218009 s at tn.png | |||||||||||
| More reference expression data | |||||||||||
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| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Protein regulator of cytokinesis 1, also known as PRC1, is a human gene.[1]
This gene encodes a protein that is involved in cytokinesis. The encoded protein is at high level during S and G2/M and drop dramatically after cell exit mitosis and enter G1. It is located in the nucleus during interphase, and becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). At least three alternatively spliced transcript variants encoding distinct isoforms have been observed.[1]
References
Further reading
- Jiang W, Jimenez G, Wells NJ; et al. (1999). "PRC1: a human mitotic spindle-associated CDK substrate protein required for cytokinesis". Mol. Cell. 2 (6): 877–85. PMID 9885575.
- Mollinari C, Kleman JP, Jiang W; et al. (2002). "PRC1 is a microtubule binding and bundling protein essential to maintain the mitotic spindle midzone". J. Cell Biol. 157 (7): 1175–86. doi:10.1083/jcb.200111052. PMID 12082078.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Ban R, Irino Y, Fukami K, Tanaka H (2004). "Human mitotic spindle-associated protein PRC1 inhibits MgcRacGAP activity toward Cdc42 during the metaphase". J. Biol. Chem. 279 (16): 16394–402. doi:10.1074/jbc.M313257200. PMID 14744859.
- Kurasawa Y, Earnshaw WC, Mochizuki Y; et al. (2005). "Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation". EMBO J. 23 (16): 3237–48. doi:10.1038/sj.emboj.7600347. PMID 15297875.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Li C, Lin M, Liu J (2005). "Identification of PRC1 as the p53 target gene uncovers a novel function of p53 in the regulation of cytokinesis". Oncogene. 23 (58): 9336–47. doi:10.1038/sj.onc.1208114. PMID 15531928.
- Mollinari C, Kleman JP, Saoudi Y; et al. (2005). "Ablation of PRC1 by small interfering RNA demonstrates that cytokinetic abscission requires a central spindle bundle in mammalian cells, whereas completion of furrowing does not". Mol. Biol. Cell. 16 (3): 1043–55. doi:10.1091/mbc.E04-04-0346. PMID 15616196.
- Zhu C, Jiang W (2005). "Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis". Proc. Natl. Acad. Sci. U.S.A. 102 (2): 343–8. doi:10.1073/pnas.0408438102. PMID 15625105.
- Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Nousiainen M, Silljé HH, Sauer G; et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMID 16565220.
- Zhu C, Lau E, Schwarzenbacher R; et al. (2006). "Spatiotemporal control of spindle midzone formation by PRC1 in human cells". Proc. Natl. Acad. Sci. U.S.A. 103 (16): 6196–201. doi:10.1073/pnas.0506926103. PMID 16603632.
- Beausoleil SA, Villén J, Gerber SA; et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
- Shimo A, Nishidate T, Ohta T; et al. (2007). "Elevated expression of protein regulator of cytokinesis 1, involved in the growth of breast cancer cells". Cancer Sci. 98 (2): 174–81. doi:10.1111/j.1349-7006.2006.00381.x. PMID 17233835.
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