HAGH

Hydroxyacylglutathione hydrolase
PDB rendering based on 1qh3.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1qh3​, 1qh5​
Identifiers
Symbols	HAGH ; GLO2; GLX2; GLXII; HAGH1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3890
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Hydroxyacylglutathione hydrolase, also known as HAGH, is a human gene.

The enzyme encoded by this gene is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate.

Further reading

• Kar NC, Pearson CM (1976). "Glyoxalase enzyme system in human muscular dystrophy". Clin. Chim. Acta. 65 (1): 153–5. PMID 1192606.
• Hamilton DS, Creighton DJ (1993). "Inhibition of glyoxalase I by the enediol mimic S-(N-hydroxy-N-methylcarbamoyl)glutathione. The possible basis of a tumor-selective anticancer strategy". J. Biol. Chem. 267 (35): 24933–6. PMID 1459997.
• Mulley JC, Barton N, Callen DF (1990). "Localisation of human PGP and HAGH genes to 16p13.3". Cytogenet. Cell Genet. 53 (2–3): 175–6. PMID 2164460.CS1 maint: Multiple names: authors list (link)
• Mulley JC, Callen DF (1987). "New regional localisations for HAGH and PGP on human chromosome 16". Hum. Genet. 74 (4): 423–4. PMID 3025077.
• Talesa V, Uotila L, Koivusalo M; et al. (1988). "Demonstration of glyoxalase II in rat liver mitochondria. Partial purification and occurrence in multiple forms". Biochim. Biophys. Acta. 955 (1): 103–10. PMID 3382669.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Thornalley PJ, Bellavite P (1987). "Modification of the glyoxalase system during the functional activation of human neutrophils". Biochim. Biophys. Acta. 931 (2): 120–9. PMID 3663711.
• Valentine WN, Paglia DE, Neerhout RC, Konrad PN (1971). "Erythrocyte glyoxalase II deficiency with coincidental hereditary elliptocytosis". Blood. 36 (6): 797–808. PMID 5485124.CS1 maint: Multiple names: authors list (link)
• Leoncini G, Maresca M, Balestrero F; et al. (1984). "Platelet glyoxalases in thrombocytosis". Scandinavian journal of haematology. 33 (1): 91–4. PMID 6463589.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Honey NK, Shows TB (1982). "Assignment of the glyoxalase II gene (HAGH) to human chromosome 16". Hum. Genet. 58 (4): 358–61. PMID 7327557.
• Board PG (1980). "Genetic polymorphism of human erythrocyte glyoxalase II". Am. J. Hum. Genet. 32 (5): 690–4. PMID 7424909.
• Di Ilio C, Angelucci S, Pennelli A; et al. (1995). "Glyoxalase activities in tumor and non-tumor human urogenital tissues". Cancer Lett. 96 (2): 189–93. PMID 7585456.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ridderström M, Saccucci F, Hellman U; et al. (1996). "Molecular cloning, heterologous expression, and characterization of human glyoxalase II". J. Biol. Chem. 271 (1): 319–23. PMID 8550579.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cameron AD, Ridderström M, Olin B, Mannervik B (1999). "Crystal structure of human glyoxalase II and its complex with a glutathione thiolester substrate analogue". Structure. 7 (9): 1067–78. PMID 10508780.CS1 maint: Multiple names: authors list (link)
• Daniels RJ, Peden JF, Lloyd C; et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. PMID 11157797.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rulli A, Carli L, Romani R; et al. (2001). "Expression of glyoxalase I and II in normal and breast cancer tissues". Breast Cancer Res. Treat. 66 (1): 67–72. PMID 11368412.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scirè A, Saccucci F, Bertoli E; et al. (2002). "Effect of acidic phospholipids on the structural properties of recombinant cytosolic human glyoxalase II". Proteins. 48 (1): 126–33. doi:10.1002/prot.10149. PMID 12012344.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mearini E, Romani R, Mearini L; et al. (2002). "Differing expression of enzymes of the glyoxalase system in superficial and invasive bladder carcinomas". Eur. J. Cancer. 38 (14): 1946–50. PMID 12204678.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cordell PA, Futers TS, Grant PJ, Pease RJ (2004). "The Human hydroxyacylglutathione hydrolase (HAGH) gene encodes both cytosolic and mitochondrial forms of glyoxalase II". J. Biol. Chem. 279 (27): 28653–61. doi:10.1074/jbc.M403470200. PMID 15117945.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)