MAP1LC3B

Microtubule-associated protein 1 light chain 3 beta
File:PBB Protein MAP1LC3B image.jpg PDB rendering based on 1ugm.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1ugm​, 1v49​, 2z0d​, 2z0e​
Identifiers
Symbols	MAP1LC3B ; MAP1A/1BLC3
External IDs	Template:MGI HomoloGene: 69359
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE MAP1LC3B 208785 s at tn.png
File:PBB GE MAP1LC3B 208786 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Microtubule-associated protein 1 light chain 3 beta, also known as MAP1LC3B, is a human gene.

The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in autophagy, a process that involves the bulk degradation of cytoplasmic component.

Further reading

• Snásel J, Pichová I (1997). "The cleavage of host cell proteins by HIV-1 protease". Folia Biol. (Praha). 42 (5): 227–30. PMID 8997639.
• Tanida I, Ueno T, Kominami E (2005). "LC3 conjugation system in mammalian autophagy". Int. J. Biochem. Cell Biol. 36 (12): 2503–18. doi:10.1016/j.biocel.2004.05.009. PMID 15325588.CS1 maint: Multiple names: authors list (link)
• Wallin M, Deinum J, Goobar L, Danielson UH (1990). "Proteolytic cleavage of microtubule-associated proteins by retroviral proteinases". J. Gen. Virol. 71 ( Pt 9): 1985–91. PMID 2212989.CS1 maint: Multiple names: authors list (link)
• Kabeya Y, Mizushima N, Ueno T; et al. (2000). "LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing". EMBO J. 19 (21): 5720–8. doi:10.1093/emboj/19.21.5720. PMID 11060023.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.CS1 maint: Multiple names: authors list (link)
• Simpson JC, Wellenreuther R, Poustka A; et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tanida I, Tanida-Miyake E, Komatsu M; et al. (2002). "Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p". J. Biol. Chem. 277 (16): 13739–44. doi:10.1074/jbc.M200385200. PMID 11825910.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tanida I, Tanida-Miyake E, Nishitani T; et al. (2002). "Murine Apg12p has a substrate preference for murine Apg7p over three Apg8p homologs". Biochem. Biophys. Res. Commun. 292 (1): 256–62. PMID 11890701.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• He H, Dang Y, Dai F; et al. (2003). "Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B". J. Biol. Chem. 278 (31): 29278–87. doi:10.1074/jbc.M303800200. PMID 12740394.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Difilippantonio S, Chen Y, Pietas A; et al. (2003). "Gene expression profiles in human non-small and small-cell lung cancers". Eur. J. Cancer. 39 (13): 1936–47. PMID 12932674.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang YS, Song HD, Peng YD; et al. (2004). "The gene expression profiling of sporadic pheochromocytoma and novel full-length cDNAs cloning". Endocr. Relat. Cancer. 10 (4): 621–7. PMID 14713272.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tanida I, Sou YS, Ezaki J; et al. (2004). "HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates". J. Biol. Chem. 279 (35): 36268–76. doi:10.1074/jbc.M401461200. PMID 15187094.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMID 15231747.
• Tanida I, Ueno T, Kominami E (2005). "Human light chain 3/MAP1LC3B is cleaved at its carboxyl-terminal Met121 to expose Gly120 for lipidation and targeting to autophagosomal membranes". J. Biol. Chem. 279 (46): 47704–10. doi:10.1074/jbc.M407016200. PMID 15355958.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wiemann S, Arlt D, Huber W; et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)