PKMYT1

Protein kinase, membrane associated tyrosine/threonine 1
Identifiers
Symbols	PKMYT1 ; MYT1; DKFZp547K1610; FLJ20093
External IDs	Template:OMIM5 Template:MGI HomoloGene: 31227
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PKMYT1 204267 x at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Protein kinase, membrane associated tyrosine/threonine 1, also known as PKMYT1, is a human gene.

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase preferentially phosphorylates and inactivates cell division cycle 2 protein (CDC2), and thus negatively regulates cell cycle G2/M transition. This kinase is associated with the membrane throughout the cell cycle. Its activity is highly regulated during the cell cycle. Protein kinases AKT1/PKB and PLK (Polo-like kinase) have been shown to phosphorylate and regulate the activity of this kinase. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Further reading

• Liu F, Stanton JJ, Wu Z, Piwnica-Worms H (1997). "The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex". Mol. Cell. Biol. 17 (2): 571–83. PMID 9001210.CS1 maint: Multiple names: authors list (link)
• Booher RN, Holman PS, Fattaey A (1997). "Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity". J. Biol. Chem. 272 (35): 22300–6. PMID 9268380.CS1 maint: Multiple names: authors list (link)
• Shen M, Stukenberg PT, Kirschner MW, Lu KP (1998). "The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins". Genes Dev. 12 (5): 706–20. PMID 9499405.CS1 maint: Multiple names: authors list (link)
• Liu F, Rothblum-Oviatt C, Ryan CE, Piwnica-Worms H (1999). "Overproduction of human Myt1 kinase induces a G2 cell cycle delay by interfering with the intracellular trafficking of Cdc2-cyclin B1 complexes". Mol. Cell. Biol. 19 (7): 5113–23. PMID 10373560.CS1 maint: Multiple names: authors list (link)
• Wells NJ, Watanabe N, Tokusumi T; et al. (1999). "The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M progression". J. Cell. Sci. 112 ( Pt 19): 3361–71. PMID 10504341.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pathan N, Aime-Sempe C, Kitada S; et al. (2001). "Microtubule-targeting drugs induce Bcl-2 phosphorylation and association with Pin1". Neoplasia. 3 (1): 70–9. doi:10.1038/sj/neo/7900131. PMID 11326318.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Okumura E, Fukuhara T, Yoshida H; et al. (2002). "Akt inhibits Myt1 in the signalling pathway that leads to meiotic G2/M-phase transition". Nat. Cell Biol. 4 (2): 111–6. doi:10.1038/ncb741. PMID 11802161.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Passer BJ, Nancy-Portebois V, Amzallag N; et al. (2003). "The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2284–9. doi:10.1073/pnas.0530298100. PMID 12606722.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakajima H, Toyoshima-Morimoto F, Taniguchi E, Nishida E (2003). "Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate". J. Biol. Chem. 278 (28): 25277–80. doi:10.1074/jbc.C300126200. PMID 12738781.CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dai X, Yamasaki K, Yang L; et al. (2004). "Keratinocyte G2/M growth arrest by 1,25-dihydroxyvitamin D3 is caused by Cdc2 phosphorylation through Wee1 and Myt1 regulation". J. Invest. Dermatol. 122 (6): 1356–64. doi:10.1111/j.0022-202X.2004.22522.x. PMID 15175024.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Martin J, Han C, Gordon LA; et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16". Nature. 432 (7020): 988–94. doi:10.1038/nature03187. PMID 15616553.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bryan BA, Dyson OF, Akula SM (2006). "Identifying cellular genes crucial for the reactivation of Kaposi's sarcoma-associated herpesvirus latency". J. Gen. Virol. 87 (Pt 3): 519–29. doi:10.1099/vir.0.81603-0. PMID 16476973.CS1 maint: Multiple names: authors list (link)
• Nousiainen M, Silljé HH, Sauer G; et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMID 16565220.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wissing J, Jänsch L, Nimtz M; et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Mol. Cell Proteomics. 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. PMID 17192257.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)