STUB1

STIP1 homology and U-box containing protein 1
File:PBB Protein STUB1 image.jpg PDB rendering based on 2c2l.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2c2l​, 2c2v​
Identifiers
Symbols	STUB1 ; CHIP; HSPABP2; NY-CO-7; SDCCAG7; UBOX1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4281
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE STUB1 217934 x at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

STIP1 homology and U-box containing protein 1, also known as STUB1, is a human gene.

Further reading

• Patterson C (2002). "A new gun in town: the U box is a ubiquitin ligase domain". Sci. STKE. 2002 (116): PE4. doi:10.1126/stke.2002.116.pe4. PMID 11805346.
• Scanlan MJ, Chen YT, Williamson B; et al. (1998). "Characterization of human colon cancer antigens recognized by autologous antibodies". Int. J. Cancer. 76 (5): 652–8. PMID 9610721.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ballinger CA, Connell P, Wu Y; et al. (1999). "Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions". Mol. Cell. Biol. 19 (6): 4535–45. PMID 10330192.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Connell P, Ballinger CA, Jiang J; et al. (2001). "The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins". Nat. Cell Biol. 3 (1): 93–6. doi:10.1038/35050618. PMID 11146632.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Daniels RJ, Peden JF, Lloyd C; et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. PMID 11157797.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jiang J, Ballinger CA, Wu Y; et al. (2001). "CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation". J. Biol. Chem. 276 (46): 42938–44. doi:10.1074/jbc.M101968200. PMID 11557750.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Demand J, Alberti S, Patterson C, Höhfeld J (2002). "Cooperation of a ubiquitin domain protein and an E3 ubiquitin ligase during chaperone/proteasome coupling". Curr. Biol. 11 (20): 1569–77. PMID 11676916.CS1 maint: Multiple names: authors list (link)
• Imai Y, Soda M, Hatakeyama S; et al. (2002). "CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity". Mol. Cell. 10 (1): 55–67. PMID 12150907.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Krackhardt AM, Witzens M, Harig S; et al. (2002). "Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX". Blood. 100 (6): 2123–31. doi:10.1182/blood-2002-02-0513. PMID 12200376.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cardozo CP, Michaud C, Ost MC; et al. (2003). "C-terminal Hsp-interacting protein slows androgen receptor synthesis and reduces its rate of degradation". Arch. Biochem. Biophys. 410 (1): 134–40. PMID 12559985.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhou P, Fernandes N, Dodge IL; et al. (2003). "ErbB2 degradation mediated by the co-chaperone protein CHIP". J. Biol. Chem. 278 (16): 13829–37. doi:10.1074/jbc.M209640200. PMID 12574167.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shimura H, Schwartz D, Gygi SP, Kosik KS (2004). "CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival". J. Biol. Chem. 279 (6): 4869–76. doi:10.1074/jbc.M305838200. PMID 14612456.CS1 maint: Multiple names: authors list (link)
• Li L, Xin H, Xu X; et al. (2004). "CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription". Mol. Cell. Biol. 24 (2): 856–64. PMID 14701756.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Petrucelli L, Dickson D, Kehoe K; et al. (2004). "CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation". Hum. Mol. Genet. 13 (7): 703–14. doi:10.1093/hmg/ddh083. PMID 14962978.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Galigniana MD, Harrell JM, Housley PR; et al. (2004). "Retrograde transport of the glucocorticoid receptor in neurites requires dynamic assembly of complexes with the protein chaperone hsp90 and is linked to the CHIP component of the machinery for proteasomal degradation". Brain Res. Mol. Brain Res. 123 (1–2): 27–36. doi:10.1016/j.molbrainres.2003.12.015. PMID 15046863.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• He B, Bai S, Hnat AT; et al. (2004). "An androgen receptor NH2-terminal conserved motif interacts with the COOH terminus of the Hsp70-interacting protein (CHIP)". J. Biol. Chem. 279 (29): 30643–53. doi:10.1074/jbc.M403117200. PMID 15107424.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Alberti S, Böhse K, Arndt V; et al. (2005). "The cochaperone HspBP1 inhibits the CHIP ubiquitin ligase and stimulates the maturation of the cystic fibrosis transmembrane conductance regulator". Mol. Biol. Cell. 15 (9): 4003–10. doi:10.1091/mbc.E04-04-0293. PMID 15215316.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)