LGALS3BP

Lectin, galactoside-binding, soluble, 3 binding protein
File:PBB Protein LGALS3BP image.jpg PDB rendering based on 1by2.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1by2​
Identifiers
Symbols	LGALS3BP ; 90K; MAC-2-BP
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4067
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE LGALS3BP 200923 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Lectin, galactoside-binding, soluble, 3 binding protein, also known as LGALS3BP, is a human gene.

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1.

Further reading

• Grassadonia A, Tinari N, Iurisci I; et al. (2004). "90K (Mac-2 BP) and galectins in tumor progression and metastasis". Glycoconj. J. 19 (7–9): 551–6. doi:10.1023/B:GLYC.0000014085.00706.d4. PMID 14758079.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rosenberg I, Cherayil BJ, Isselbacher KJ, Pillai S (1991). "Mac-2-binding glycoproteins. Putative ligands for a cytosolic beta-galactoside lectin". J. Biol. Chem. 266 (28): 18731–6. PMID 1917996.CS1 maint: Multiple names: authors list (link)
• Yu B, Wright SD (1995). "LPS-dependent interaction of Mac-2-binding protein with immobilized CD14". J. Inflamm. 45 (2): 115–25. PMID 7583357.
• Calabrese G, Sures I, Pompetti F; et al. (1995). "The gene (LGALS3BP) encoding the serum protein 90K, associated with cancer and infection by the human immunodeficiency virus, maps at 17q25". Cytogenet. Cell Genet. 69 (3–4): 223–5. PMID 7698018.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ullrich A, Sures I, D'Egidio M; et al. (1994). "The secreted tumor-associated antigen 90K is a potent immune stimulator". J. Biol. Chem. 269 (28): 18401–7. PMID 8034587.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Koths K, Taylor E, Halenbeck R; et al. (1993). "Cloning and characterization of a human Mac-2-binding protein, a new member of the superfamily defined by the macrophage scavenger receptor cysteine-rich domain". J. Biol. Chem. 268 (19): 14245–9. PMID 8390986.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Inohara H, Akahani S, Koths K, Raz A (1996). "Interactions between galectin-3 and Mac-2-binding protein mediate cell-cell adhesion". Cancer Res. 56 (19): 4530–4. PMID 8813152.CS1 maint: Multiple names: authors list (link)
• Brakebusch C, Jallal B, Fusco O; et al. (1997). "Expression of the 90K immunostimulator gene is controlled by a promoter with unique features". J. Biol. Chem. 272 (6): 3674–82. PMID 9013622.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fusco O, Querzoli P, Nenci I; et al. (1998). "90K (MAC-2 BP) gene expression in breast cancer and evidence for the production of 90K by peripheral-blood mononuclear cells". Int. J. Cancer. 79 (1): 23–6. PMID 9495353.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sasaki T, Brakebusch C, Engel J, Timpl R (1998). "Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin". EMBO J. 17 (6): 1606–13. doi:10.1093/emboj/17.6.1606. PMID 9501082.CS1 maint: Multiple names: authors list (link)
• Trahey M, Weissman IL (1999). "Cyclophilin C-associated protein: a normal secreted glycoprotein that down-modulates endotoxin and proinflammatory responses in vivo". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 3006–11. PMID 10077627.
• Tinari N, Kuwabara I, Huflejt ME; et al. (2001). "Glycoprotein 90K/MAC-2BP interacts with galectin-1 and mediates galectin-1-induced cell aggregation". Int. J. Cancer. 91 (2): 167–72. PMID 11146440.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hellstern S, Sasaki T, Fauser C; et al. (2002). "Functional studies on recombinant domains of Mac-2-binding protein". J. Biol. Chem. 277 (18): 15690–6. doi:10.1074/jbc.M200386200. PMID 11867635.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Marchetti A, Tinari N, Buttitta F; et al. (2002). "Expression of 90K (Mac-2 BP) correlates with distant metastasis and predicts survival in stage I non-small cell lung cancer patients". Cancer Res. 62 (9): 2535–9. PMID 11980646.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry". Nat. Biotechnol. 21 (6): 660–6. doi:10.1038/nbt827. PMID 12754519.CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bouwmeester T, Bauch A, Ruffner H; et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kristiansen TZ, Bunkenborg J, Gronborg M; et al. (2005). "A proteomic analysis of human bile". Mol. Cell Proteomics. 3 (7): 715–28. doi:10.1074/mcp.M400015-MCP200. PMID 15084671.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)