Profilin 1

Profilin 1
File:PBB Protein PFN1 image.jpg PDB rendering based on 1awi.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1awi​, 1cf0​, 1cjf​, 1fik​, 1fil​, 1hlu​, 1pfl​, 1pne​, 2btf​
Identifiers
Symbols	PFN1 ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3684
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PFN1 200634 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Profilin 1, also known as PFN1, is a human gene.

The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome.

Further reading

• Qualmann B, Kessels MM (2003). "Endocytosis and the cytoskeleton". Int. Rev. Cytol. 220: 93–144. PMID 12224553.
• Kwiatkowski DJ, Aklog L, Ledbetter DH, Morton CC (1990). "Identification of the functional profilin gene, its localization to chromosome subband 17p13.3, and demonstration of its deletion in some patients with Miller-Dieker syndrome". Am. J. Hum. Genet. 46 (3): 559–67. PMID 1968707.CS1 maint: Multiple names: authors list (link)
• Ampe C, Markey F, Lindberg U, Vandekerckhove J (1988). "The primary structure of human platelet profilin: reinvestigation of the calf spleen profilin sequence". FEBS Lett. 228 (1): 17–21. PMID 3342873.CS1 maint: Multiple names: authors list (link)
• Kwiatkowski DJ, Bruns GA (1988). "Human profilin. Molecular cloning, sequence comparison, and chromosomal analysis". J. Biol. Chem. 263 (12): 5910–5. PMID 3356709.
• Gieselmann R, Kwiatkowski DJ, Janmey PA, Witke W (1995). "Distinct biochemical characteristics of the two human profilin isoforms". Eur. J. Biochem. 229 (3): 621–8. PMID 7758455.CS1 maint: Multiple names: authors list (link)
• Kato S, Sekine S, Oh SW; et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. PMID 7821789.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Metzler WJ, Constantine KL, Friedrichs MS; et al. (1994). "Characterization of the three-dimensional solution structure of human profilin: 1H, 13C, and 15N NMR assignments and global folding pattern". Biochemistry. 32 (50): 13818–29. PMID 8268157.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schutt CE, Myslik JC, Rozycki MD; et al. (1993). "The structure of crystalline profilin-beta-actin". Nature. 365 (6449): 810–6. doi:10.1038/365810a0. PMID 8413665.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mahoney NM, Janmey PA, Almo SC (1997). "Structure of the profilin-poly-L-proline complex involved in morphogenesis and cytoskeletal regulation". Nat. Struct. Biol. 4 (11): 953–60. PMID 9360613.CS1 maint: Multiple names: authors list (link)
• Mammoto A, Sasaki T, Asakura T; et al. (1998). "Interactions of drebrin and gephyrin with profilin". Biochem. Biophys. Res. Commun. 243 (1): 86–9. doi:10.1006/bbrc.1997.8068. PMID 9473484.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bhargavi V, Chari VB, Singh SS (1998). "Phosphatidylinositol 3-kinase binds to profilin through the p85 alpha subunit and regulates cytoskeletal assembly". Biochem. Mol. Biol. Int. 46 (2): 241–8. PMID 9801792.CS1 maint: Multiple names: authors list (link)
• Suetsugu S, Miki H, Takenawa T (1999). "The essential role of profilin in the assembly of actin for microspike formation". EMBO J. 17 (22): 6516–26. doi:10.1093/emboj/17.22.6516. PMID 9822597.CS1 maint: Multiple names: authors list (link)
• Miki H, Suetsugu S, Takenawa T (1999). "WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac". EMBO J. 17 (23): 6932–41. doi:10.1093/emboj/17.23.6932. PMID 9843499.CS1 maint: Multiple names: authors list (link)
• Mahoney NM, Rozwarski DA, Fedorov E; et al. (1999). "Profilin binds proline-rich ligands in two distinct amide backbone orientations". Nat. Struct. Biol. 6 (7): 666–71. doi:10.1038/10722. PMID 10404225.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nunoi H, Yamazaki T, Tsuchiya H; et al. (1999). "A heterozygous mutation of beta-actin associated with neutrophil dysfunction and recurrent infection". Proc. Natl. Acad. Sci. U.S.A. 96 (15): 8693–8. PMID 10411937.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Murphy GA, Solski PA, Jillian SA; et al. (1999). "Cellular functions of TC10, a Rho family GTPase: regulation of morphology, signal transduction and cell growth". Oncogene. 18 (26): 3831–45. doi:10.1038/sj.onc.1202758. PMID 10445846.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Harbeck B, Hüttelmaier S, Schluter K; et al. (2000). "Phosphorylation of the vasodilator-stimulated phosphoprotein regulates its interaction with actin". J. Biol. Chem. 275 (40): 30817–25. doi:10.1074/jbc.M005066200. PMID 10882740.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Boettner B, Govek EE, Cross J, Van Aelst L (2000). "The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 9064–9. PMID 10922060.CS1 maint: Multiple names: authors list (link)
• Yayoshi-Yamamoto S, Taniuchi I, Watanabe T (2000). "FRL, a novel formin-related protein, binds to Rac and regulates cell motility and survival of macrophages". Mol. Cell. Biol. 20 (18): 6872–81. PMID 10958683.CS1 maint: Multiple names: authors list (link)
• Mellon MB, Frank BT, Fang KC (2002). "Mast cell alpha-chymase reduces IgE recognition of birch pollen profilin by cleaving antibody-binding epitopes". J. Immunol. 168 (1): 290–7. PMID 11751973.CS1 maint: Multiple names: authors list (link)