IGF2BP1

Insulin-like growth factor 2 mRNA binding protein 1
Identifiers
Symbols	IGF2BP1 ; CRD-BP; CRDBP; IMP-1; IMP1; VICKZ1; ZBP1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4772
Gene ontology Molecular function Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Insulin-like growth factor 2 mRNA binding protein 1, also known as IGF2BP1, is a human gene.

This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation.

Further reading

• Yaniv K, Yisraeli JK (2002). "The involvement of a conserved family of RNA binding proteins in embryonic development and carcinogenesis". Gene. 287 (1–2): 49–54. PMID 11992722.
• Yisraeli JK (2005). "VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins". Biol. Cell. 97 (1): 87–96. doi:10.1042/BC20040151. PMID 15601260.
• Prokipcak RD, Herrick DJ, Ross J (1994). "Purification and properties of a protein that binds to the C-terminal coding region of human c-myc mRNA". J. Biol. Chem. 269 (12): 9261–9. PMID 8132663.CS1 maint: Multiple names: authors list (link)
• Doyle GA, Betz NA, Leeds PF; et al. (1999). "The c-myc coding region determinant-binding protein: a member of a family of KH domain RNA-binding proteins". Nucleic Acids Res. 26 (22): 5036–44. PMID 9801297.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nielsen J, Christiansen J, Lykke-Andersen J; et al. (1999). "A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development". Mol. Cell. Biol. 19 (2): 1262–70. PMID 9891060.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Runge S, Nielsen FC, Nielsen J; et al. (2000). "H19 RNA binds four molecules of insulin-like growth factor II mRNA-binding protein". J. Biol. Chem. 275 (38): 29562–9. doi:10.1074/jbc.M001156200. PMID 10875929.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nielsen FC, Nielsen J, Kristensen MA; et al. (2003). "Cytoplasmic trafficking of IGF-II mRNA-binding protein by conserved KH domains". J. Cell. Sci. 115 (Pt 10): 2087–97. PMID 11973350.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lemm I, Ross J (2002). "Regulation of c-myc mRNA decay by translational pausing in a coding region instability determinant". Mol. Cell. Biol. 22 (12): 3959–69. PMID 12024010.
• Ioannidis P, Mahaira L, Papadopoulou A; et al. (2003). "8q24 Copy number gains and expression of the c-myc mRNA stabilizing protein CRD-BP in primary breast carcinomas". Int. J. Cancer. 104 (1): 54–9. doi:10.1002/ijc.10794. PMID 12532419.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nielsen J, Adolph SK, Rajpert-De Meyts E; et al. (2003). "Nuclear transit of human zipcode-binding protein IMP1". Biochem. J. 376 (Pt 2): 383–91. doi:10.1042/BJ20030943. PMID 12921532.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gu L, Shigemasa K, Ohama K (2004). "Increased expression of IGF II mRNA-binding protein 1 mRNA is associated with an advanced clinical stage and poor prognosis in patients with ovarian cancer". Int. J. Oncol. 24 (3): 671–8. PMID 14767552.CS1 maint: Multiple names: authors list (link)
• Hansen TV, Hammer NA, Nielsen J; et al. (2004). "Dwarfism and impaired gut development in insulin-like growth factor II mRNA-binding protein 1-deficient mice". Mol. Cell. Biol. 24 (10): 4448–64. PMID 15121863.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ioannidis P, Kottaridi C, Dimitriadis E; et al. (2004). "Expression of the RNA-binding protein CRD-BP in brain and non-small cell lung tumors". Cancer Lett. 209 (2): 245–50. doi:10.1016/j.canlet.2003.12.015. PMID 15159028.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rackham O, Brown CM (2005). "Visualization of RNA-protein interactions in living cells: FMRP and IMP1 interact on mRNAs". EMBO J. 23 (16): 3346–55. doi:10.1038/sj.emboj.7600341. PMID 15282548.
• Nielsen J, Kristensen MA, Willemoës M; et al. (2004). "Sequential dimerization of human zipcode-binding protein IMP1 on RNA: a cooperative mechanism providing RNP stability". Nucleic Acids Res. 32 (14): 4368–76. doi:10.1093/nar/gkh754. PMID 15314207.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yamashita R, Shirota M; et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liao B, Patel M, Hu Y; et al. (2005). "Targeted knockdown of the RNA-binding protein CRD-BP promotes cell proliferation via an insulin-like growth factor II-dependent pathway in human K562 leukemia cells". J. Biol. Chem. 279 (47): 48716–24. doi:10.1074/jbc.M405853200. PMID 15355996.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)