RASD1

RAS, dexamethasone-induced 1
Identifiers
Symbols	RASD1 ; AGS1; DEXRAS1; MGC:26290
External IDs	Template:OMIM5 Template:MGI HomoloGene: 7509
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE RASD1 gnf1h00203 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

RAS, dexamethasone-induced 1, also known as RASD1, is a human gene.

This gene encodes a Ras-related protein that is stimulated by dexamethasone. The exact function of this gene is unknown, but it may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. In addition, studies of a similar rat protein suggest that it functions as as a novel physiologic nitric oxide (NO) effector. The gene product belongs to the Ras superfamily of small GTPases.

Further reading

• Kemppainen RJ, Behrend EN (1998). "Dexamethasone rapidly induces a novel ras superfamily member-related gene in AtT-20 cells". J. Biol. Chem. 273 (6): 3129–31. PMID 9452419.
• Cismowski MJ, Takesono A, Ma C; et al. (1999). "Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling". Nat. Biotechnol. 17 (9): 878–83. doi:10.1038/12867. PMID 10471929.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tu Y, Wu C (2000). "Cloning, expression and characterization of a novel human Ras-related protein that is regulated by glucocorticoid hormone". Biochim. Biophys. Acta. 1489 (2–3): 452–6. PMID 10673050.
• Cismowski MJ, Ma C, Ribas C; et al. (2000). "Activation of heterotrimeric G-protein signaling by a ras-related protein. Implications for signal integration". J. Biol. Chem. 275 (31): 23421–4. doi:10.1074/jbc.C000322200. PMID 10840027.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• St Croix B, Rago C, Velculescu V; et al. (2000). "Genes expressed in human tumor endothelium". Science. 289 (5482): 1197–202. PMID 10947988.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.CS1 maint: Multiple names: authors list (link)
• Fang M, Jaffrey SR, Sawa A; et al. (2000). "Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON". Neuron. 28 (1): 183–93. PMID 11086993.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ognjanovic S, Bao S, Yamamoto SY; et al. (2001). "Genomic organization of the gene coding for human pre-B-cell colony enhancing factor and expression in human fetal membranes". J. Mol. Endocrinol. 26 (2): 107–17. PMID 11241162.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takesono A, Nowak MW, Cismowski M; et al. (2002). "Activator of G-protein signaling 1 blocks GIRK channel activation by a G-protein-coupled receptor: apparent disruption of receptor signaling complexes". J. Biol. Chem. 277 (16): 13827–30. doi:10.1074/jbc.M201064200. PMID 11842095.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bi W, Yan J, Stankiewicz P; et al. (2002). "Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse". Genome Res. 12 (5): 713–28. doi:10.1101/gr.73702. PMID 11997338.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jaffrey SR, Fang M, Snyder SH (2003). "Nitrosopeptide mapping: a novel methodology reveals s-nitrosylation of dexras1 on a single cysteine residue". Chem. Biol. 9 (12): 1329–35. PMID 12498886.CS1 maint: Multiple names: authors list (link)
• Kemppainen RJ, Cox E, Behrend EN; et al. (2003). "Identification of a glucocorticoid response element in the 3'-flanking region of the human Dexras1 gene". Biochim. Biophys. Acta. 1627 (2–3): 85–9. PMID 12818426.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vaidyanathan G, Cismowski MJ, Wang G; et al. (2004). "The Ras-related protein AGS1/RASD1 suppresses cell growth". Oncogene. 23 (34): 5858–63. doi:10.1038/sj.onc.1207774. PMID 15184869.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wiemann S, Arlt D, Huber W; et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hiskens R, Vatish M, Hill C; et al. (2005). "Specific in vivo binding of activator of G protein signalling 1 to the Gbeta1 subunit". Biochem. Biophys. Res. Commun. 337 (4): 1038–46. doi:10.1016/j.bbrc.2005.09.149. PMID 16225846.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mehrle A, Rosenfelder H, Schupp I; et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nguyen CH, Watts VJ (2006). "Dexamethasone-induced Ras protein 1 negatively regulates protein kinase C delta: implications for adenylyl cyclase 2 signaling". Mol. Pharmacol. 69 (5): 1763–71. doi:10.1124/mol.105.019133. PMID 16489124.