C1QBP
| Complement component 1, q subcomponent binding protein | |||||||||||||
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 PDB rendering based on 1p32. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | C1QBP ; GC1QBP; HABP1; SF2p32; gC1Q-R; gC1qR; p32 | ||||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 31023 | ||||||||||||
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| Species | Human | Mouse | |||||||||||
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Complement component 1, q subcomponent binding protein, also known as C1QBP, is a human gene.[1]
The human complement subcomponent C1q associates with C1r and C1s in order to yield the first component of the serum complement system. The protein encoded by this gene is known to bind to the globular heads of C1q molecules and inhibit C1 activation. This protein has also been identified as the p32 subunit of pre-mRNA splicing factor SF2, as well as a hyaluronic acid-binding protein.[1]
References
Further reading
- Krainer AR, Mayeda A, Kozak D, Binns G (1991). "Functional expression of cloned human splicing factor SF2: homology to RNA-binding proteins, U1 70K, and Drosophila splicing regulators". Cell. 66 (2): 383–94. PMID 1830244.
- Busby TF, Ingham KC (1990). "NH2-terminal calcium-binding domain of human complement C1s- mediates the interaction of C1r- with C1q". Biochemistry. 29 (19): 4613–8. PMID 2372546.
- Fridell RA, Harding LS, Bogerd HP, Cullen BR (1995). "Identification of a novel human zinc finger protein that specifically interacts with the activation domain of lentiviral Tat proteins". Virology. 209 (2): 347–57. doi:10.1006/viro.1995.1266. PMID 7778269.
- Luo Y, Yu H, Peterlin BM (1994). "Cellular protein modulates effects of human immunodeficiency virus type 1 Rev". J. Virol. 68 (6): 3850–6. PMID 8189522.
- Ghebrehiwet B, Lim BL, Peerschke EI; et al. (1994). "Isolation, cDNA cloning, and overexpression of a 33-kD cell surface glycoprotein that binds to the globular "heads" of C1q". J. Exp. Med. 179 (6): 1809–21. PMID 8195709.
- Honoré B, Madsen P, Rasmussen HH; et al. (1994). "Cloning and expression of a cDNA covering the complete coding region of the P32 subunit of human pre-mRNA splicing factor SF2". Gene. 134 (2): 283–7. PMID 8262387.
- Deb TB, Datta K (1996). "Molecular cloning of human fibroblast hyaluronic acid-binding protein confirms its identity with P-32, a protein co-purified with splicing factor SF2. Hyaluronic acid-binding protein as P-32 protein, co-purified with splicing factor SF2". J. Biol. Chem. 271 (4): 2206–12. PMID 8567680.
- Tange TO, Jensen TH, Kjems J (1996). "In vitro interaction between human immunodeficiency virus type 1 Rev protein and splicing factor ASF/SF2-associated protein, p32". J. Biol. Chem. 271 (17): 10066–72. PMID 8626563.
- Guo N, Weremowicz S, Lynch N; et al. (1997). "Assignment of C1QBP encoding the C1q globular domain binding protein (gC1q-R) to human chromosome 17 band p13.3 by in situ hybridization". Cytogenet. Cell Genet. 77 (3–4): 283–4. PMID 9284938.
- Majumdar M, Datta K (1998). "Assignment of cDNA encoding hyaluronic acid-binding protein 1 to human chromosome 17p12-p13". Genomics. 51 (3): 476–7. doi:10.1006/geno.1998.5364. PMID 9721222.
- Petersen-Mahrt SK, Estmer C, Ohrmalm C; et al. (1999). "The splicing factor-associated protein, p32, regulates RNA splicing by inhibiting ASF/SF2 RNA binding and phosphorylation". EMBO J. 18 (4): 1014–24. doi:10.1093/emboj/18.4.1014. PMID 10022843.
- Jiang J, Zhang Y, Krainer AR, Xu RM (1999). "Crystal structure of human p32, a doughnut-shaped acidic mitochondrial matrix protein". Proc. Natl. Acad. Sci. U.S.A. 96 (7): 3572–7. PMID 10097078.
- Braun L, Ghebrehiwet B, Cossart P (2000). "gC1q-R/p32, a C1q-binding protein, is a receptor for the InlB invasion protein of Listeria monocytogenes". EMBO J. 19 (7): 1458–66. doi:10.1093/emboj/19.7.1458. PMID 10747014.
- Beatch MD, Hobman TC (2000). "Rubella virus capsid associates with host cell protein p32 and localizes to mitochondria". J. Virol. 74 (12): 5569–76. PMID 10823864.
- Storz P, Hausser A, Link G; et al. (2000). "Protein kinase C [micro] is regulated by the multifunctional chaperon protein p32". J. Biol. Chem. 275 (32): 24601–7. doi:10.1074/jbc.M002964200. PMID 10831594.
- Tye AJ, Ghebrehiwet B, Guo N; et al. (2001). "The human gC1qR/p32 gene, C1qBP. Genomic organization and promoter analysis". J. Biol. Chem. 276 (20): 17069–75. doi:10.1074/jbc.M009064200. PMID 11278463.
- Schaerer MT, Kannenberg K, Hunziker P; et al. (2001). "Interaction between GABA(A) receptor beta subunits and the multifunctional protein gC1q-R". J. Biol. Chem. 276 (28): 26597–604. doi:10.1074/jbc.M102534200. PMID 11350968.
- Kobayashi M, Hanai R (2001). "M phase-specific association of human topoisomerase IIIbeta with chromosomes". Biochem. Biophys. Res. Commun. 287 (1): 282–7. doi:10.1006/bbrc.2001.5580. PMID 11549288.
- Rozanov DV, Ghebrehiwet B, Postnova TI; et al. (2002). "The hemopexin-like C-terminal domain of membrane type 1 matrix metalloproteinase regulates proteolysis of a multifunctional protein, gC1qR". J. Biol. Chem. 277 (11): 9318–25. doi:10.1074/jbc.M110711200. PMID 11773076.
- Majumdar M, Meenakshi J, Goswami SK, Datta K (2002). "Hyaluronan binding protein 1 (HABP1)/C1QBP/p32 is an endogenous substrate for MAP kinase and is translocated to the nucleus upon mitogenic stimulation". Biochem. Biophys. Res. Commun. 291 (4): 829–37. doi:10.1006/bbrc.2002.6491. PMID 11866440.
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