MAP3K14
| Mitogen-activated protein kinase kinase kinase 14 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbols | MAP3K14 ; FTDCR1B; HS; HSNIK; NIK | ||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 2940 | ||||||||
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| RNA expression pattern | |||||||||
| File:PBB GE MAP3K14 205192 at tn.png | |||||||||
| More reference expression data | |||||||||
| Orthologs | |||||||||
| Template:GNF Ortholog box | |||||||||
| Species | Human | Mouse | |||||||
| Entrez | n/a | n/a | |||||||
| Ensembl | n/a | n/a | |||||||
| UniProt | n/a | n/a | |||||||
| RefSeq (mRNA) | n/a | n/a | |||||||
| RefSeq (protein) | n/a | n/a | |||||||
| Location (UCSC) | n/a | n/a | |||||||
| PubMed search | n/a | n/a | |||||||
Mitogen-activated protein kinase kinase kinase 14, also known as MAP3K14, is a human gene.[1]
This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.[1]
References
Further reading
- Malinin NL, Boldin MP, Kovalenko AV, Wallach D (1997). "MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1". Nature. 385 (6616): 540–4. doi:10.1038/385540a0. PMID 9020361.
- Régnier CH, Song HY, Gao X; et al. (1997). "Identification and characterization of an IkappaB kinase". Cell. 90 (2): 373–83. PMID 9244310.
- Song HY, Régnier CH, Kirschning CJ; et al. (1997). "Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2". Proc. Natl. Acad. Sci. U.S.A. 94 (18): 9792–6. PMID 9275204.
- Woronicz JD, Gao X, Cao Z; et al. (1997). "IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK". Science. 278 (5339): 866–9. PMID 9346485.
- Ling L, Cao Z, Goeddel DV (1998). "NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176". Proc. Natl. Acad. Sci. U.S.A. 95 (7): 3792–7. PMID 9520446.
- Lee FS, Peters RT, Dang LC, Maniatis T (1998). "MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta". Proc. Natl. Acad. Sci. U.S.A. 95 (16): 9319–24. PMID 9689078.
- Lin X, Mu Y, Cunningham ET; et al. (1998). "Molecular determinants of NF-kappaB-inducing kinase action". Mol. Cell. Biol. 18 (10): 5899–907. PMID 9742107.
- Cohen L, Henzel WJ, Baeuerle PA (1998). "IKAP is a scaffold protein of the IkappaB kinase complex". Nature. 395 (6699): 292–6. doi:10.1038/26254. PMID 9751059.
- Aronsson FC, Magnusson P, Andersson B; et al. (1998). "The NIK protein kinase and C17orf1 genes: chromosomal mapping, gene structures and mutational screening in frontotemporal dementia and parkinsonism linked to chromosome 17". Hum. Genet. 103 (3): 340–5. PMID 9799091.
- Nemoto S, DiDonato JA, Lin A (1998). "Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase". Mol. Cell. Biol. 18 (12): 7336–43. PMID 9819420.
- Li Y, Kang J, Friedman J; et al. (1999). "Identification of a cell protein (FIP-3) as a modulator of NF-kappaB activity and as a target of an adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis". Proc. Natl. Acad. Sci. U.S.A. 96 (3): 1042–7. PMID 9927690.
- Lallena MJ, Diaz-Meco MT, Bren G; et al. (1999). "Activation of IkappaB kinase beta by protein kinase C isoforms". Mol. Cell. Biol. 19 (3): 2180–8. PMID 10022904.
- Lin X, Cunningham ET, Mu Y; et al. (1999). "The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases". Immunity. 10 (2): 271–80. PMID 10072079.
- Ninomiya-Tsuji J, Kishimoto K, Hiyama A; et al. (1999). "The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway". Nature. 398 (6724): 252–6. doi:10.1038/18465. PMID 10094049.
- Delhase M, Hayakawa M, Chen Y, Karin M (1999). "Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation". Science. 284 (5412): 309–13. PMID 10195894.
- Hu WH, Johnson H, Shu HB (1999). "Tumor necrosis factor-related apoptosis-inducing ligand receptors signal NF-kappaB and JNK activation and apoptosis through distinct pathways". J. Biol. Chem. 274 (43): 30603–10. PMID 10521444.
- Yamamoto Y, Yin MJ, Gaynor RB (2000). "IkappaB kinase alpha (IKKalpha) regulation of IKKbeta kinase activity". Mol. Cell. Biol. 20 (10): 3655–66. PMID 10779355.
- Xiao G, Sun SC (2000). "Negative regulation of the nuclear factor kappa B-inducing kinase by a cis-acting domain". J. Biol. Chem. 275 (28): 21081–5. doi:10.1074/jbc.M002552200. PMID 10887201.
- Chaudhary PM, Eby MT, Jasmin A; et al. (2000). "Activation of the NF-kappaB pathway by caspase 8 and its homologs". Oncogene. 19 (39): 4451–60. doi:10.1038/sj.onc.1203812. PMID 11002417.
- Kumar A, Eby MT, Sinha S; et al. (2001). "The ectodermal dysplasia receptor activates the nuclear factor-kappaB, JNK, and cell death pathways and binds to ectodysplasin A.". J. Biol. Chem. 276 (4): 2668–77. doi:10.1074/jbc.M008356200. PMID 11035039.
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