TRIM37
| Tripartite motif-containing 37 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbols | TRIM37 ; KIAA0898; MUL; POB1; TEF3 | ||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 9084 | ||||||||
| |||||||||
| RNA expression pattern | |||||||||
| File:PBB GE TRIM37 213009 s at tn.png | |||||||||
| More reference expression data | |||||||||
| Orthologs | |||||||||
| Template:GNF Ortholog box | |||||||||
| Species | Human | Mouse | |||||||
| Entrez | n/a | n/a | |||||||
| Ensembl | n/a | n/a | |||||||
| UniProt | n/a | n/a | |||||||
| RefSeq (mRNA) | n/a | n/a | |||||||
| RefSeq (protein) | n/a | n/a | |||||||
| Location (UCSC) | n/a | n/a | |||||||
| PubMed search | n/a | n/a | |||||||
Tripartite motif-containing 37, also known as TRIM37, is a human gene.[1]
This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. Alternatively spliced transcript variants encoding the same protein have been identified.[1]
References
Further reading
- Avela K, Lipsanen-Nyman M, Perheentupa J; et al. (1997). "Assignment of the mulibrey nanism gene to 17q by linkage and linkage-disequilibrium analysis". Am. J. Hum. Genet. 60 (4): 896–902. PMID 9106536.
- Nagase T, Ishikawa K, Suyama M; et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. PMID 10048485.
- Avela K, Lipsanen-Nyman M, Idänheimo N; et al. (2000). "Gene encoding a new RING-B-box-Coiled-coil protein is mutated in mulibrey nanism". Nat. Genet. 25 (3): 298–301. doi:10.1038/77053. PMID 10888877.
- Zapata JM, Pawlowski K, Haas E; et al. (2001). "A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains". J. Biol. Chem. 276 (26): 24242–52. doi:10.1074/jbc.M100354200. PMID 11279055.
- Reymond A, Meroni G, Fantozzi A; et al. (2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMID 11331580.
- Lehesjoki AE, Reed VA, Mark Gardiner R, Greene ND (2002). "Expression of MUL, a gene encoding a novel RBCC family ring-finger protein, in human and mouse embryogenesis". Mech. Dev. 108 (1–2): 221–5. PMID 11578880.
- Kallijärvi J, Avela K, Lipsanen-Nyman M; et al. (2002). "The TRIM37 gene encodes a peroxisomal RING-B-box-coiled-coil protein: classification of mulibrey nanism as a new peroxisomal disorder". Am. J. Hum. Genet. 70 (5): 1215–28. PMID 11938494.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Jagiello P, Hammans C, Wieczorek S; et al. (2003). "A novel splice site mutation in the TRIM37 gene causes mulibrey nanism in a Turkish family with phenotypic heterogeneity". Hum. Mutat. 21 (6): 630–5. doi:10.1002/humu.10220. PMID 12754710.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Hämäläinen RH, Avela K, Lambert JA; et al. (2004). "Novel mutations in the TRIM37 gene in Mulibrey Nanism". Hum. Mutat. 23 (5): 522. doi:10.1002/humu.9233. PMID 15108285.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Kallijärvi J, Lahtinen U, Hämäläinen R; et al. (2005). "TRIM37 defective in mulibrey nanism is a novel RING finger ubiquitin E3 ligase". Exp. Cell Res. 308 (1): 146–55. doi:10.1016/j.yexcr.2005.04.001. PMID 15885686.
- Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Karlberg N, Jalanko H, Kallijärvi J; et al. (2006). "Insulin resistance syndrome in subjects with mutated RING finger protein TRIM37". Diabetes. 54 (12): 3577–81. PMID 16306379.
- Hämäläinen RH, Joensuu T, Kallijärvi J, Lehesjoki AE (2006). "Characterisation of the mulibrey nanism-associated TRIM37 gene: transcription initiation, promoter region and alternative splicing". Gene. 366 (1): 180–8. doi:10.1016/j.gene.2005.08.008. PMID 16310976.
- Lim J, Hao T, Shaw C; et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
- Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Hämäläinen RH, Mowat D, Gabbett MT; et al. (2007). "Wilms' tumor and novel TRIM37 mutations in an Australian patient with mulibrey nanism". Clin. Genet. 70 (6): 473–9. doi:10.1111/j.1399-0004.2006.00700.x. PMID 17100991.
- Doğanc T, Yüksel Konuk BE, Alpan N; et al. (2007). "A novel mutation in TRIM37 is associated with mulibrey nanism in a Turkish boy". Clin. Dysmorphol. 16 (3): 173–6. doi:10.1097/MCD.0b013e3280f6d00b. PMID 17551331.
 | This protein-related article is a stub. You can help Wikipedia by expanding it. |