TRIM25

Tripartite motif-containing 25
Identifiers
Symbols	TRIM25 ; EFP; RNF147; Z147; ZNF147
External IDs	Template:OMIM5 Template:MGI HomoloGene: 48325
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO
RNA expression pattern
File:PBB GE TRIM25 206911 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Tripartite motif-containing 25, also known as TRIM25, is a human gene.

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene.

Further reading

• Horie K, Urano T, Ikeda K, Inoue S (2003). "Estrogen-responsive RING finger protein controls breast cancer growth". J. Steroid Biochem. Mol. Biol. 85 (2–5): 101–4. PMID 12943693.CS1 maint: Multiple names: authors list (link)
• Inoue S, Orimo A, Matsuda Y; et al. (1995). "Chromosome mapping of human (ZNF147) and mouse genes for estrogen-responsive finger protein (efp), a member of the RING finger family". Genomics. 25 (2): 581–3. PMID 7789997.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Inoue S, Orimo A, Hosoi T; et al. (1994). "Genomic binding-site cloning reveals an estrogen-responsive gene that encodes a RING finger protein". Proc. Natl. Acad. Sci. U.S.A. 90 (23): 11117–21. PMID 8248217.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Ikeda K, Inoue S, Orimo A; et al. (1997). "Multiple regulatory elements and binding proteins of the 5'-flanking region of the human estrogen-responsive finger protein (efp) gene". Biochem. Biophys. Res. Commun. 236 (3): 765–71. doi:10.1006/bbrc.1997.7046. PMID 9245730.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ikeda K, Orimo A, Higashi Y; et al. (2000). "Efp as a primary estrogen-responsive gene in human breast cancer". FEBS Lett. 472 (1): 9–13. PMID 10781795.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Reymond A, Meroni G, Fantozzi A; et al. (2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMID 11331580.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Urano T, Saito T, Tsukui T; et al. (2002). "Efp targets 14-3-3 sigma for proteolysis and promotes breast tumour growth". Nature. 417 (6891): 871–5. doi:10.1038/nature00826. PMID 12075357.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shimada N, Suzuki T, Inoue S; et al. (2004). "Systemic distribution of estrogen-responsive finger protein (Efp) in human tissues". Mol. Cell. Endocrinol. 218 (1–2): 147–53. doi:10.1016/j.mce.2003.12.008. PMID 15130519.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rush J, Moritz A, Lee KA; et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki T, Urano T, Tsukui T; et al. (2005). "Estrogen-responsive finger protein as a new potential biomarker for breast cancer". Clin. Cancer Res. 11 (17): 6148–54. doi:10.1158/1078-0432.CCR-05-0040. PMID 16144914.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakayama H, Sano T, Motegi A; et al. (2005). "Increasing 14-3-3 sigma expression with declining estrogen receptor alpha and estrogen-responsive finger protein expression defines malignant progression of endometrial carcinoma". Pathol. Int. 55 (11): 707–15. doi:10.1111/j.1440-1827.2005.01900.x. PMID 16271083.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakasato N, Ikeda K, Urano T; et al. (2007). "A ubiquitin E3 ligase Efp is up-regulated by interferons and conjugated with ISG15". Biochem. Biophys. Res. Commun. 351 (2): 540–6. doi:10.1016/j.bbrc.2006.10.061. PMID 17069755.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakajima A, Maruyama S, Bohgaki M; et al. (2007). "Ligand-dependent transcription of estrogen receptor alpha is mediated by the ubiquitin ligase EFP". Biochem. Biophys. Res. Commun. 357 (1): 245–51. doi:10.1016/j.bbrc.2007.03.134. PMID 17418098.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)