NT5C
| 5', 3'-nucleotidase, cytosolic | |||||||||||
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| Identifiers | |||||||||||
| Symbols | NT5C ; DNT; DNT1; P5N2; PN-I; PN-II; UMPH2; cdN; dNT-1 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 8745 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE NT5C 219214 s at tn.png | |||||||||||
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| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
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| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
5', 3'-nucleotidase, cytosolic, also known as NT5C, is a human gene.[1]
Pyrimidine 5-prime nucleotidase (P5N; EC 3.1.3.5), also called uridine 5-prime monophosphate hydrolase (UMPH), catalyzes the dephosphorylation of the pyrimidine 5-prime monophosphates UMP and CMP to the corresponding nucleosides. There are 2 isozymes of pyrimidine 5-prime nucleotidase in red blood cells, referred to as type I (UMPH1; MIM 606224) and type II (UMPH2).[supplied by OMIM][1]
References
Further reading
- Höglund L, Reichard P (1990). "Cytoplasmic 5'(3')-nucleotidase from human placenta". J. Biol. Chem. 265 (12): 6589–95. PMID 2157703.
- Wilson DE, Swallow DM, Povey S (1988). "Assignment of the human gene for uridine 5'-monophosphate phosphohydrolase (UMPH2) to the long arm of chromosome 17". Ann. Hum. Genet. 50 (Pt 3): 223–7. PMID 2833155.
- Xu WM, Gorman PA, Rider SH; et al. (1988). "Construction of a genetic map of human chromosome 17 by use of chromosome-mediated gene transfer". Proc. Natl. Acad. Sci. U.S.A. 85 (22): 8563–7. PMID 3186746.
- Rampazzo C, Johansson M, Gallinaro L; et al. (2000). "Mammalian 5'(3')-deoxyribonucleotidase, cDNA cloning, and overexpression of the enzyme in Escherichia coli and mammalian cells". J. Biol. Chem. 275 (8): 5409–15. PMID 10681516.
- Rampazzo C, Gallinaro L, Milanesi E; et al. (2000). "A deoxyribonucleotidase in mitochondria: involvement in regulation of dNTP pools and possible link to genetic disease". Proc. Natl. Acad. Sci. U.S.A. 97 (15): 8239–44. PMID 10899995.
- Rampazzo C, Kost-Alimova M, Ruzzenente B; et al. (2003). "Mouse cytosolic and mitochondrial deoxyribonucleotidases: cDNA cloning of the mitochondrial enzyme, gene structures, chromosomal mapping and comparison with the human orthologs". Gene. 294 (1–2): 109–17. PMID 12234672.
- Amici A, Emanuelli M, Ruggieri S; et al. (2003). "Kinetic evidence for covalent phosphoryl-enzyme intermediate in phosphotransferase activity of human red cell pyrimidine nucleotidases". Meth. Enzymol. 354: 149–59. PMID 12418222.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Balta G, Gumruk F, Akarsu N; et al. (2003). "Molecular characterization of Turkish patients with pyrimidine 5' nucleotidase-I deficiency". Blood. 102 (5): 1900–3. doi:10.1182/blood-2003-02-0628. PMID 12714505.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Galmarini CM, Cros E, Graham K; et al. (2006). "5'-(3')-nucleotidase mRNA levels in blast cells are a prognostic factor in acute myeloid leukemia patients treated with cytarabine". Haematologica. 89 (5): 617–9. PMID 15136231.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
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