SEPT4
| Septin 4 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | SEPT4 ; H5; ARTS; CE5B3; PNUTL2; hCDCREL-2; hucep-7 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 6107 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE SEPT4 210657 s at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Septin 4, also known as SEPT4, is a human gene.[1]
This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. The protein encoded by this gene is thought to be part of a complex involved in cytokinesis. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.[1]
References
Further reading
- Paavola P, Horelli-Kuitunen N, Palotie A, Peltonen L (1999). "Characterization of a novel gene, PNUTL2, on human chromosome 17q22-q23 and its exclusion as the Meckel syndrome gene". Genomics. 55 (1): 122–5. doi:10.1006/geno.1998.5612. PMID 9889007.
- Xie H, Surka M, Howard J, Trimble WS (1999). "Characterization of the mammalian septin H5: distinct patterns of cytoskeletal and membrane association from other septin proteins". Cell Motil. Cytoskeleton. 43 (1): 52–62. doi:10.1002/(SICI)1097-0169(1999)43:1<52::AID-CM6>3.0.CO;2-5. PMID 10340703.
- Larisch S, Yi Y, Lotan R; et al. (2001). "A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif". Nat. Cell Biol. 2 (12): 915–21. doi:10.1038/35046566. PMID 11146656.
- Zieger B, Tran H, Hainmann I; et al. (2001). "Characterization and expression analysis of two human septin genes, PNUTL1 and PNUTL2". Gene. 261 (2): 197–203. PMID 11167005.
- Tanaka M, Tanaka T, Kijima H; et al. (2001). "Characterization of tissue- and cell-type-specific expression of a novel human septin family gene, Bradeion". Biochem. Biophys. Res. Commun. 286 (3): 547–53. doi:10.1006/bbrc.2001.5413. PMID 11511094.
- Tanaka M, Kijima H, Itoh J; et al. (2002). "Impaired expression of a human septin family gene Bradeion inhibits the growth and tumorigenesis of colorectal cancer in vitro and in vivo". Cancer Gene Ther. 9 (6): 483–8. doi:10.1038/sj.cgt.7700460. PMID 12032658.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Vega IE, Hsu SC (2003). "The septin protein Nedd5 associates with both the exocyst complex and microtubules and disruption of its GTPase activity promotes aberrant neurite sprouting in PC12 cells". Neuroreport. 14 (1): 31–7. doi:10.1097/01.wnr.0000050304.92401.50. PMID 12544826.
- Ihara M, Tomimoto H, Kitayama H; et al. (2003). "Association of the cytoskeletal GTP-binding protein Sept4/H5 with cytoplasmic inclusions found in Parkinson's disease and other synucleinopathies". J. Biol. Chem. 278 (26): 24095–102. doi:10.1074/jbc.M301352200. PMID 12695511.
- Choi P, Snyder H, Petrucelli L; et al. (2004). "SEPT5_v2 is a parkin-binding protein". Brain Res. Mol. Brain Res. 117 (2): 179–89. PMID 14559152.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gottfried Y, Rotem A, Lotan R; et al. (2005). "The mitochondrial ARTS protein promotes apoptosis through targeting XIAP". EMBO J. 23 (7): 1627–35. doi:10.1038/sj.emboj.7600155. PMID 15029247.
- Bläser S, Horn J, Würmell P; et al. (2004). "The novel human platelet septin SEPT8 is an interaction partner of SEPT4". Thromb. Haemost. 91 (5): 959–66. doi:10.1267/THRO04050959. PMID 15116257.
- Elhasid R, Sahar D, Merling A; et al. (2004). "Mitochondrial pro-apoptotic ARTS protein is lost in the majority of acute lymphoblastic leukemia patients". Oncogene. 23 (32): 5468–75. doi:10.1038/sj.onc.1207725. PMID 15122323.
- Martínez C, Sanjuan MA, Dent JA; et al. (2005). "Human septin-septin interactions as a prerequisite for targeting septin complexes in the cytosol". Biochem. J. 382 (Pt 3): 783–91. doi:10.1042/BJ20040372. PMID 15214843.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Lotan R, Rotem A, Gonen H; et al. (2005). "Regulation of the proapoptotic ARTS protein by ubiquitin-mediated degradation". J. Biol. Chem. 280 (27): 25802–10. doi:10.1074/jbc.M501955200. PMID 15837787.
- Lee JW, Soung YH, Young Kim S; et al. (2006). "Mutational analysis of proapoptotic ARTS P-loop domain in common human cancers". Pathol. Res. Pract. 202 (2): 67–70. doi:10.1016/j.prp.2005.11.001. PMID 16376484.
- Lee JW, Soung YH, Kim SY; et al. (2006). "Mutational analysis of P-loop domains of proapoptotic Nod1 and ARTS genes in colon carcinomas". Acta oncologica (Stockholm, Sweden). 45 (1): 101–2. doi:10.1080/02841860500374497. PMID 16464805.
- Garcia W, de Araújo AP, Neto Mde O; et al. (2007). "Dissection of a human septin: definition and characterization of distinct domains within human SEPT4". Biochemistry. 45 (46): 13918–31. doi:10.1021/bi061549z. PMID 17105210.
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