Protein inhibitor of activated STAT2

Protein inhibitor of activated STAT, 2
Identifiers
Symbols	PIAS2 ; MGC102682; MIZ1; PIASX-ALPHA; PIASX-BETA; SIZ2; ZMIZ4; miz
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20979
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PIAS2 37433 at tn.png
File:PBB GE PIAS2 214442 s at tn.png
File:PBB GE PIAS2 214593 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Protein inhibitor of activated STAT, 2, also known as PIAS2, is a human gene.

Further reading

• Cookson MR (2003). "Pathways to Parkinsonism". Neuron. 37 (1): 7–10. PMID 12526767.
• Wu L, Wu H, Ma L; et al. (1997). "Miz1, a novel zinc finger transcription factor that interacts with Msx2 and enhances its affinity for DNA". Mech. Dev. 65 (1–2): 3–17. PMID 9256341.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu B, Liao J, Rao X; et al. (1998). "Inhibition of Stat1-mediated gene activation by PIAS1". Proc. Natl. Acad. Sci. U.S.A. 95 (18): 10626–31. PMID 9724754.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Moilanen AM, Karvonen U, Poukka H; et al. (1999). "A testis-specific androgen receptor coregulator that belongs to a novel family of nuclear proteins". J. Biol. Chem. 274 (6): 3700–4. PMID 9920921.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Minty A, Dumont X, Kaghad M, Caput D (2000). "Covalent modification of p73alpha by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif". J. Biol. Chem. 275 (46): 36316–23. doi:10.1074/jbc.M004293200. PMID 10961991.CS1 maint: Multiple names: authors list (link)
• Kotaja N, Aittomäki S, Silvennoinen O; et al. (2001). "ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activation". Mol. Endocrinol. 14 (12): 1986–2000. PMID 11117529.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gross M, Liu B, Tan J; et al. (2001). "Distinct effects of PIAS proteins on androgen-mediated gene activation in prostate cancer cells". Oncogene. 20 (29): 3880–7. doi:10.1038/sj.onc.1204489. PMID 11439351.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takahashi K, Taira T, Niki T; et al. (2001). "DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor". J. Biol. Chem. 276 (40): 37556–63. doi:10.1074/jbc.M101730200. PMID 11477070.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schmidt D, Müller S (2002). "Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity". Proc. Natl. Acad. Sci. U.S.A. 99 (5): 2872–7. doi:10.1073/pnas.052559499. PMID 11867732.
• Tan JA, Hall SH, Hamil KG; et al. (2002). "Protein inhibitors of activated STAT resemble scaffold attachment factors and function as interacting nuclear receptor coregulators". J. Biol. Chem. 277 (19): 16993–7001. doi:10.1074/jbc.M109217200. PMID 11877418.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nishida T, Yasuda H (2003). "PIAS1 and PIASxalpha function as SUMO-E3 ligases toward androgen receptor and repress androgen receptor-dependent transcription". J. Biol. Chem. 277 (44): 41311–7. doi:10.1074/jbc.M206741200. PMID 12177000.
• Tussie-Luna MI, Michel B, Hakre S, Roy AL (2003). "The SUMO ubiquitin-protein isopeptide ligase family member Miz1/PIASxbeta /Siz2 is a transcriptional cofactor for TFII-I". J. Biol. Chem. 277 (45): 43185–93. doi:10.1074/jbc.M207635200. PMID 12193603.CS1 maint: Multiple names: authors list (link)
• Tussié-Luna MI, Bayarsaihan D, Seto E; et al. (2002). "Physical and functional interactions of histone deacetylase 3 with TFII-I family proteins and PIASxbeta". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 12807–12. doi:10.1073/pnas.192464499. PMID 12239342.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Miyauchi Y, Yogosawa S, Honda R; et al. (2003). "Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes". J. Biol. Chem. 277 (51): 50131–6. doi:10.1074/jbc.M208319200. PMID 12393906.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Arora T, Liu B, He H; et al. (2003). "PIASx is a transcriptional co-repressor of signal transducer and activator of transcription 4". J. Biol. Chem. 278 (24): 21327–30. doi:10.1074/jbc.C300119200. PMID 12716907.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ohshima T, Shimotohno K (2004). "Transforming growth factor-beta-mediated signaling via the p38 MAP kinase pathway activates Smad-dependent transcription through SUMO-1 modification of Smad4". J. Biol. Chem. 278 (51): 50833–42. doi:10.1074/jbc.M307533200. PMID 14514699.
• Lee BH, Yoshimatsu K, Maeda A; et al. (2004). "Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related molecules". Virus Res. 98 (1): 83–91. PMID 14609633.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lehner B, Semple JI, Brown SE; et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. PMID 14667819.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)