Methyl-CpG-binding domain protein 2

Methyl-CpG binding domain protein 2
Identifiers
Symbols	MBD2 ; DKFZp586O0821; DMTase; NY-CO-41
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2918
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE MBD2 202484 s at tn.png
File:PBB GE MBD2 202485 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Methyl-CpG binding domain protein 2, also known as MBD2, is a human gene.

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing.

Further reading

• Scanlan MJ, Chen YT, Williamson B; et al. (1998). "Characterization of human colon cancer antigens recognized by autologous antibodies". Int. J. Cancer. 76 (5): 652–8. PMID 9610721.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hendrich B, Bird A (1998). "Identification and characterization of a family of mammalian methyl-CpG binding proteins". Mol. Cell. Biol. 18 (11): 6538–47. PMID 9774669.
• Zhang Y, LeRoy G, Seelig HP; et al. (1998). "The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities". Cell. 95 (2): 279–89. PMID 9790534.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tong JK, Hassig CA, Schnitzler GR; et al. (1998). "Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex". Nature. 395 (6705): 917–21. doi:10.1038/27699. PMID 9804427.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bhattacharya SK, Ramchandani S, Cervoni N, Szyf M (1999). "A mammalian protein with specific demethylase activity for mCpG DNA". Nature. 397 (6720): 579–83. doi:10.1038/17533. PMID 10050851.CS1 maint: Multiple names: authors list (link)
• Hendrich B, Abbott C, McQueen H; et al. (1999). "Genomic structure and chromosomal mapping of the murine and human Mbd1, Mbd2, Mbd3, and Mbd4 genes". Mamm. Genome. 10 (9): 906–12. PMID 10441743.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang Y, Ng HH, Erdjument-Bromage H; et al. (1999). "Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation". Genes Dev. 13 (15): 1924–35. PMID 10444591.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ng HH, Zhang Y, Hendrich B; et al. (1999). "MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex". Nat. Genet. 23 (1): 58–61. doi:10.1038/12659. PMID 10471499.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tatematsu KI, Yamazaki T, Ishikawa F (2000). "MBD2-MBD3 complex binds to hemi-methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase". Genes Cells. 5 (8): 677–88. PMID 10947852.CS1 maint: Multiple names: authors list (link)
• Boeke J, Ammerpohl O, Kegel S; et al. (2001). "The minimal repression domain of MBD2b overlaps with the methyl-CpG-binding domain and binds directly to Sin3A". J. Biol. Chem. 275 (45): 34963–7. doi:10.1074/jbc.M005929200. PMID 10950960.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Humphrey GW, Wang Y, Russanova VR; et al. (2001). "Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1". J. Biol. Chem. 276 (9): 6817–24. doi:10.1074/jbc.M007372200. PMID 11102443.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Feng Q, Zhang Y (2001). "The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomes". Genes Dev. 15 (7): 827–32. doi:10.1101/gad.876201. PMID 11297506.
• Sekimata M, Takahashi A, Murakami-Sekimata A, Homma Y (2001). "Involvement of a novel zinc finger protein, MIZF, in transcriptional repression by interacting with a methyl-CpG-binding protein, MBD2". J. Biol. Chem. 276 (46): 42632–8. doi:10.1074/jbc.M107048200. PMID 11553631.CS1 maint: Multiple names: authors list (link)
• Müller-Tidow C, Kügler K, Diederichs S; et al. (2001). "Loss of expression of HDAC-recruiting methyl-CpG-binding domain proteins in human cancer". Br. J. Cancer. 85 (8): 1168–74. doi:10.1054/bjoc.2001.2041. PMID 11710831.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Feng Q, Cao R, Xia L; et al. (2002). "Identification and functional characterization of the p66/p68 components of the MeCP1 complex". Mol. Cell. Biol. 22 (2): 536–46. PMID 11756549.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bakker J, Lin X, Nelson WG (2002). "Methyl-CpG binding domain protein 2 represses transcription from hypermethylated pi-class glutathione S-transferase gene promoters in hepatocellular carcinoma cells". J. Biol. Chem. 277 (25): 22573–80. doi:10.1074/jbc.M203009200. PMID 11960994.CS1 maint: Multiple names: authors list (link)
• Saito M, Ishikawa F (2002). "The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2". J. Biol. Chem. 277 (38): 35434–9. doi:10.1074/jbc.M203455200. PMID 12124384.
• Detich N, Theberge J, Szyf M (2002). "Promoter-specific activation and demethylation by MBD2/demethylase". J. Biol. Chem. 277 (39): 35791–4. doi:10.1074/jbc.C200408200. PMID 12177048.CS1 maint: Multiple names: authors list (link)
• Brackertz M, Boeke J, Zhang R, Renkawitz R (2002). "Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3". J. Biol. Chem. 277 (43): 40958–66. doi:10.1074/jbc.M207467200. PMID 12183469.CS1 maint: Multiple names: authors list (link)
• Krithivas A, Fujimuro M, Weidner M; et al. (2002). "Protein interactions targeting the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus to cell chromosomes". J. Virol. 76 (22): 11596–604. PMID 12388720.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)